00:00:01.710 --> 00:00:04.796
- Nice shot. 21-20 Wright State.

00:00:04.796 --> 00:00:06.881
Short quarter, right,
Custer back out to Alstork.

00:00:06.881 --> 00:00:08.466
Custer again in the corner.

00:00:08.466 --> 00:00:10.385
Mitchell, back out to Alstork.

00:00:10.385 --> 00:00:11.886
Alstork back to Custer.

00:00:11.886 --> 00:00:13.763
Line drive three, deep
in the right corner.

00:00:13.763 --> 00:00:15.682
He can do it. His first
three as a Raider.

00:00:15.682 --> 00:00:17.559
- That's great execution, Chris.

00:00:17.559 --> 00:00:19.728
- Custer wide open
will try another one.

00:00:19.728 --> 00:00:21.396
He's got two in a row.

00:00:21.396 --> 00:00:22.814
The freshmen from
Cincinnati Elder.

00:00:22.814 --> 00:00:24.691
Leans in, back out.

00:00:24.691 --> 00:00:25.650
Custer, can he make it
three for three for three?

00:00:25.650 --> 00:00:27.485
He does.

00:00:27.485 --> 00:00:29.738
Ryan Custer with a record three
threes in this first half.

00:00:29.738 --> 00:00:32.490
and the Raiders jumped
out to a 37-15 lead.

00:00:32.490 --> 00:00:34.826
- Elder High School graduate
and Wright State freshmen,

00:00:34.826 --> 00:00:37.412
Ryan Custer, remains
in critical condition

00:00:37.412 --> 00:00:39.080
after suffering a neck injury

00:00:39.080 --> 00:00:40.874
while inside a
makeshift wading pool.

00:00:40.874 --> 00:00:42.584
This all happened
at a house party

00:00:42.584 --> 00:00:44.085
in Oxford over the weekend.

00:00:44.085 --> 00:00:46.921
Police say as many as
300 people were there,

00:00:52.886 --> 00:00:56.639
- Kim was outside getting
some sun on our patio.

00:00:56.639 --> 00:00:58.850
And my oldest son, Nick,

00:00:58.850 --> 00:01:01.102
he was in the kitchen,
his phone rang.

00:01:01.102 --> 00:01:03.480
And all of a sudden
we hear Nick say,

00:01:03.480 --> 00:01:05.607
"What's wrong with my brother?"

00:01:06.983 --> 00:01:08.860
And told him that
Ryan had been hurt

00:01:08.860 --> 00:01:11.696
and the paramedics were there
so he hands me the phone.

00:01:11.696 --> 00:01:14.824
And he said, "He's
involved in an accident."

00:01:14.824 --> 00:01:16.701
And I'm like, "An accident?"

00:01:16.701 --> 00:01:18.620
I said, "Was he driving?

00:01:18.620 --> 00:01:20.914
'Cause he wasn't supposed
to be driving his car."

00:01:20.914 --> 00:01:23.750
And he said, "No,
it involves a pool."

00:01:23.750 --> 00:01:26.461
And my worst nightmare.

00:01:26.461 --> 00:01:30.507
And I'm like, "Did
he break his neck?"

00:01:30.507 --> 00:01:32.509
And he goes, "I don't know, sir.

00:01:32.509 --> 00:01:35.512
You need to go to UC
Hospital in Cincinnati.

00:01:35.512 --> 00:01:37.472
We're gonna air care him there."

00:01:37.472 --> 00:01:39.724
And I'm like, "Can
he feel his legs?"

00:01:39.724 --> 00:01:42.435
He goes, "I don't know, sir.

00:01:42.435 --> 00:01:44.646
You need to go to the hospital."

00:01:54.697 --> 00:01:56.825
- My husband and I
were taking turns

00:01:56.825 --> 00:01:59.577
staying in ICU with
Ryan spending the night.

00:01:59.577 --> 00:02:02.831
So that Tuesday morning
when I got into the hospital

00:02:02.831 --> 00:02:05.750
and Ryan must had a bad night,

00:02:05.750 --> 00:02:07.710
his dad didn't get any sleep.

00:02:07.710 --> 00:02:12.507
And Ryan told his dad, "I
don't think I can do this."

00:02:13.550 --> 00:02:15.009
So that really upset George

00:02:15.009 --> 00:02:17.929
and George came out
of Ryan's room crying.

00:02:17.929 --> 00:02:20.473
(soft music)

00:02:22.684 --> 00:02:24.102
- We're just looking for hope.

00:02:24.102 --> 00:02:25.937
I mean, you see your
son laying there,

00:02:25.937 --> 00:02:29.732
no feeling below his
chest and it's just tough.

00:02:29.732 --> 00:02:32.735
And I said, "Your mom and
I are here, your siblings,

00:02:32.735 --> 00:02:34.195
your family and friends."

00:02:34.195 --> 00:02:36.656
I said, "But you have
to be the one to fight."

00:02:36.656 --> 00:02:38.575
I said, "In the end, it's you."

00:02:38.575 --> 00:02:39.450
You know?

00:02:41.452 --> 00:02:44.539
He goes, he said, "Dad,"
he goes, "I got this."

00:02:59.721 --> 00:03:02.557
- You're gonna start to feel
a little warmth in your IV,

00:03:02.557 --> 00:03:03.975
that's super normal.

00:03:03.975 --> 00:03:05.768
When you feel that
warm sensation,

00:03:05.768 --> 00:03:07.896
that's your signal to
start dreaming, okay?

00:03:07.896 --> 00:03:09.480
- Okay.

00:03:09.480 --> 00:03:11.065
- Taking really good
care of you here today.

00:03:11.065 --> 00:03:12.567
- Thank you.

00:03:12.567 --> 00:03:13.902
- Have sweet dreams.

00:03:17.071 --> 00:03:19.741
Another deep breath, doing okay?

00:03:20.867 --> 00:03:21.868
Good.

00:03:23.828 --> 00:03:26.748
(fast piano music)

00:03:33.004 --> 00:03:35.256
- 20 years from now

00:03:35.256 --> 00:03:38.801
you will not recognize
medicine as it is known today.

00:03:43.765 --> 00:03:45.183
- It's a miracle.

00:03:45.183 --> 00:03:47.560
It's something that
has unlimited potential

00:03:47.560 --> 00:03:49.229
for curing people.

00:03:49.229 --> 00:03:52.523
- We are really on the cusp
of having this explosion

00:03:52.523 --> 00:03:54.234
in the whole field of medicine.

00:03:54.234 --> 00:03:56.110
- Hypertension, blindness.
- Spinal cord injuries.

00:03:56.110 --> 00:03:57.570
- Diabetes. Heart problems.

00:03:57.570 --> 00:03:59.030
- Cerebral palsy. Cancer.

00:03:59.030 --> 00:04:01.115
- These aren't even
all of the diseases.

00:04:01.115 --> 00:04:04.619
- We believe that the research
being proposed is immoral,

00:04:04.619 --> 00:04:06.788
illegal and unnecessary.

00:04:08.665 --> 00:04:11.000
- It's the need to balance
value and respect for life

00:04:11.000 --> 00:04:13.127
with the promise of science.

00:04:13.127 --> 00:04:14.754
- Ryan.
- Mom!

00:04:16.005 --> 00:04:18.007
- We have two
choices here, George,

00:04:18.007 --> 00:04:20.760
one is we use these
embryonic stem cells

00:04:20.760 --> 00:04:23.221
to save lives or
we throw them away.

00:04:25.556 --> 00:04:29.811
- This research offers the
potential to eliminate diseases.

00:04:29.811 --> 00:04:32.981
Literally save
millions of lives.

00:04:32.981 --> 00:04:35.608
- Stem cells hold the cure

00:04:35.608 --> 00:04:37.819
for many life-threatening
ailments.

00:04:52.083 --> 00:04:55.837
♪ Happy birthday dear Steve

00:04:55.837 --> 00:04:58.798
♪ Happy birthday to you.

00:05:00.633 --> 00:05:01.634
- Yay!
- Yay!

00:05:03.928 --> 00:05:05.305
That's awesome.

00:05:05.305 --> 00:05:07.223
Yes, yes yes.

00:05:07.223 --> 00:05:09.183
- Something woke me up and
I don't know what it was.

00:05:09.183 --> 00:05:12.061
I threw back the sheets and I
ran around the side of the bed

00:05:12.061 --> 00:05:14.856
to his side and he was
making a weird noise.

00:05:14.856 --> 00:05:17.692
His jaw was set in this
like sort of rectangular

00:05:17.692 --> 00:05:20.028
unnatural way.

00:05:20.028 --> 00:05:21.362
And he was gray.

00:05:21.362 --> 00:05:23.239
This is his normal color.

00:05:23.239 --> 00:05:26.034
You know, he's always
been kind of like peach.

00:05:26.034 --> 00:05:27.160
(laughing)

00:05:27.160 --> 00:05:29.746
And so for him to be so gray,

00:05:29.746 --> 00:05:32.665
I got water in a cup and
I threw water on him.

00:05:32.665 --> 00:05:34.792
I was yelling at him,
"Is this a joke?"

00:05:34.792 --> 00:05:38.379
I was you shouting at him,
"I'm going to call 911

00:05:38.379 --> 00:05:40.757
and the ambulance
is going to come

00:05:40.757 --> 00:05:42.884
and they're going to
take you to the hospital.

00:05:42.884 --> 00:05:44.302
Do you want to go
to the hospital?

00:05:44.302 --> 00:05:46.012
Is that what you
want to have happen?

00:05:46.012 --> 00:05:47.889
Wake up."

00:05:47.889 --> 00:05:51.934
And so finally he like double
blinks and he says, "Hey."

00:05:51.934 --> 00:05:55.271
And I was like, "Hey."

00:05:55.271 --> 00:05:58.358
And then brain tumor.

00:05:59.275 --> 00:06:01.402
(sniffling)

00:06:02.904 --> 00:06:04.989
I felt like everything
was just getting

00:06:04.989 --> 00:06:07.033
flushed down the
toilet right then.

00:06:07.033 --> 00:06:10.286
- So, you know, the
goal is to go take out

00:06:10.286 --> 00:06:11.913
this bulky part here.

00:06:11.913 --> 00:06:14.415
We'll wake you up
during surgery.

00:06:14.415 --> 00:06:16.084
- You're gonna do it awake?

00:06:16.084 --> 00:06:17.377
- Yeah. And then
to put a catheter

00:06:17.377 --> 00:06:19.170
to the ventricle.

00:06:19.170 --> 00:06:21.130
So the advantage of that is

00:06:21.130 --> 00:06:24.092
the cells would come out and
then spread to this cavity

00:06:24.092 --> 00:06:27.095
but also they can spread
to the other tumor areas.

00:06:28.971 --> 00:06:30.932
We've seen patients like you

00:06:30.932 --> 00:06:33.267
with these types of
tumors really respond

00:06:33.267 --> 00:06:36.270
so let's cross our fingers.

00:06:36.270 --> 00:06:37.313
- Okay.

00:06:37.313 --> 00:06:38.856
- All right.

00:06:42.944 --> 00:06:46.114
- Okay, where's Milan?
- I don't know.

00:06:46.114 --> 00:06:47.949
- Milan?
- Yeah.

00:06:47.949 --> 00:06:50.201
- Where are you sweetie?
- Right here in the sun room.

00:06:50.201 --> 00:06:51.828
- Did you get your crepe?

00:06:51.828 --> 00:06:52.870
- Yeah.
- Oh, okay.

00:06:52.870 --> 00:06:55.039
- I became legally blind

00:06:55.039 --> 00:06:57.041
after the birth of our daughter,

00:06:57.041 --> 00:06:58.459
our third child.

00:06:58.459 --> 00:07:01.129
And that was 13 years ago.

00:07:01.129 --> 00:07:03.256
- You got to put your name.
- I forgot.

00:07:03.256 --> 00:07:05.133
- What are you guys doing?

00:07:05.133 --> 00:07:06.968
It's just like an optional
class she can take right now.

00:07:06.968 --> 00:07:09.720
It's a club, career club.
- Oh.

00:07:09.720 --> 00:07:11.889
And it wasn't until
I was about 26

00:07:11.889 --> 00:07:13.808
that I went to Jules Stein

00:07:13.808 --> 00:07:16.352
and he confirmed that I
had retinitis pigmentosa.

00:07:16.352 --> 00:07:19.939
And he said, "There's no cure."

00:07:19.939 --> 00:07:23.818
And when he said that, I
thought, are you kidding me?

00:07:23.818 --> 00:07:26.362
We just found out we
were gonna have twins.

00:07:26.362 --> 00:07:28.781
It was a lot, it
was a lot to handle.

00:07:28.781 --> 00:07:30.908
I'm trying to contain
myself and say,

00:07:30.908 --> 00:07:33.327
"Okay, hopefully it's
gonna be really slow

00:07:33.327 --> 00:07:36.831
and hopefully I will be able
to see my kids grow up."

00:07:36.831 --> 00:07:41.836
And having three kids,
having one with special needs

00:07:43.045 --> 00:07:46.215
and dealing with my vision loss,

00:07:46.215 --> 00:07:49.177
it was a lot, it
was a lot to handle.

00:07:49.177 --> 00:07:53.014
- It's just become our
normal where we accept

00:07:53.014 --> 00:07:56.058
that she can't see, she
can't do certain things,

00:07:56.058 --> 00:07:59.812
she can't drive, she can't
go for walks by herself.

00:07:59.812 --> 00:08:02.190
There's a lot of things
that she can't do.

00:08:02.190 --> 00:08:03.900
- Watch your step
right here, honey.

00:08:03.900 --> 00:08:05.359
- Okay.

00:08:05.359 --> 00:08:07.278
I used to read to
the kids every night

00:08:07.278 --> 00:08:10.448
and just one night I couldn't
couldn't get through the book.

00:08:10.448 --> 00:08:12.366
I definitely cried about that

00:08:12.366 --> 00:08:15.328
because it was something
that I love to do

00:08:15.328 --> 00:08:18.039
and I couldn't do that
with them anymore.

00:08:18.039 --> 00:08:20.374
It wasn't something I
could share with them.

00:08:20.374 --> 00:08:21.459
Hey, buddy.

00:08:21.459 --> 00:08:23.085
Are you hungry?
- Donuts.

00:08:23.085 --> 00:08:25.379
- Alessandro, how many
donuts did you eat?

00:08:25.379 --> 00:08:27.548
- One.
- You had two.

00:08:27.548 --> 00:08:30.885
But then three years ago
is when we met Dr. Klassen

00:08:30.885 --> 00:08:32.803
and we realized there's hope

00:08:32.803 --> 00:08:34.472
because there's the stem cell

00:08:34.472 --> 00:08:37.183
and this could potentially
restore my vision,

00:08:37.183 --> 00:08:41.395
and I was really hoping and
praying that I would be chosen.

00:08:41.395 --> 00:08:43.397
And one of the coordinators,

00:08:43.397 --> 00:08:45.233
he's the one that let us know,

00:08:45.233 --> 00:08:47.860
"You made it, you're
patient number six."

00:08:47.860 --> 00:08:50.571
And I just, I ran out of
there and I'm going yeah!

00:08:50.571 --> 00:08:53.032
Yes, yes! I made it!

00:09:03.334 --> 00:09:06.087
- I think some people
are just dreamers,

00:09:06.087 --> 00:09:08.339
if we want to use that term.

00:09:08.339 --> 00:09:10.424
And I think I fall
in that category.

00:09:10.424 --> 00:09:12.593
I decided that
retinitis pigmentosa

00:09:12.593 --> 00:09:15.596
was gonna be what I
was gonna try to fix.

00:09:15.596 --> 00:09:19.141
Now, one thing is that it's
a very devastating disease.

00:09:19.141 --> 00:09:22.603
So with RP, it starts off,

00:09:22.603 --> 00:09:27.233
it's just a difficulty at
night with night vision

00:09:27.233 --> 00:09:29.110
and then it progresses

00:09:29.110 --> 00:09:31.988
and then people get
this tunnel effect.

00:09:31.988 --> 00:09:35.116
And then the tunnel gets
tighter and tighter and tighter

00:09:35.116 --> 00:09:39.287
and then eventually vision
winks out altogether.

00:09:39.287 --> 00:09:42.623
So it's a really devastating
disease and it disrupts

00:09:42.623 --> 00:09:47.628
people's visual capabilities
during the prime of life.

00:09:47.628 --> 00:09:51.132
- That's part of the mark of
the injection up to the left,

00:09:51.132 --> 00:09:52.925
betadine right there
just to make sure

00:09:52.925 --> 00:09:54.635
it's nice and
sterile in that area.

00:09:54.635 --> 00:09:57.930
- I still remember looking
down the microscope

00:09:57.930 --> 00:10:00.141
for the first time
to see these results.

00:10:00.141 --> 00:10:02.518
And here you have to
kind of be a scientist

00:10:02.518 --> 00:10:04.562
who's looked down a
lot of microscopes

00:10:04.562 --> 00:10:07.023
and seen a lot of
lousy results. (laughs)

00:10:07.023 --> 00:10:11.193
And I looked down there
and I saw the future.

00:10:12.612 --> 00:10:15.281
I saw something that I
never thought I'd see

00:10:15.281 --> 00:10:16.949
in my lifetime.

00:10:16.949 --> 00:10:19.452
Here were these green
fluorescent stem cells

00:10:19.452 --> 00:10:21.412
that just integrated
in this retina

00:10:21.412 --> 00:10:23.247
and then they were lining up.

00:10:23.247 --> 00:10:25.041
They knew the right address.

00:10:25.041 --> 00:10:26.500
They just plugged right in.

00:10:26.500 --> 00:10:28.127
They were hooking up.

00:10:28.127 --> 00:10:30.630
I was blown away.

00:10:32.465 --> 00:10:35.593
And I think at that moment,
I said, "Okay, I'm all in.

00:10:37.178 --> 00:10:39.138
- The injection, look
up high to your left.

00:10:41.515 --> 00:10:44.518
Up high to the left,
good, nice and still.

00:11:03.037 --> 00:11:04.121
Complete.

00:11:25.559 --> 00:11:28.020
- Are you stressed out, Andy?

00:11:29.605 --> 00:11:32.650
Your pulse isn't very
relaxed either. (laughing)

00:11:32.650 --> 00:11:34.402
- No?

00:11:34.402 --> 00:11:38.114
- Imagine your resting
heart rate's probably

00:11:38.114 --> 00:11:40.032
in the, at least 60s.

00:11:41.742 --> 00:11:44.245
- Yeah.
- So yeah.

00:11:44.245 --> 00:11:46.455
Oh, there it's
going down a little

00:11:46.455 --> 00:11:48.416
just hearing my soothing voice.

00:11:48.416 --> 00:11:50.418
- That's what it is, I'm sure.

00:11:50.418 --> 00:11:52.420
(Terry laughing)

00:12:01.220 --> 00:12:02.763
- All right.

00:12:02.763 --> 00:12:05.099
So this is Caldwell, Andrew.

00:12:07.560 --> 00:12:10.271
- Today's actually,
it's exactly five years

00:12:10.271 --> 00:12:12.690
to the day that I found
out I was HIV positive.

00:12:12.690 --> 00:12:14.108
- Oh, really?
- Yeah.

00:12:14.108 --> 00:12:15.109
- Today.
- Mm-hmm.

00:12:15.109 --> 00:12:16.777
- Wow.

00:12:16.777 --> 00:12:19.029
- Yeah, it was two days
before my birthday in 2013.

00:12:19.029 --> 00:12:23.451
So it's kind of
serendipitous. (laughing)

00:12:25.244 --> 00:12:29.457
In November of 2012,
just before Thanksgiving,

00:12:29.457 --> 00:12:33.419
I came down with what I
thought was the worst flu

00:12:33.419 --> 00:12:35.463
that I've ever felt in my life.

00:12:35.463 --> 00:12:38.048
Like body was achy, was weak,

00:12:38.048 --> 00:12:40.050
I had to go to
urgent care twice.

00:12:41.469 --> 00:12:43.804
I remember them being
so puzzled by it

00:12:43.804 --> 00:12:46.724
because I had no respiratory
symptoms of the flu.

00:12:46.724 --> 00:12:48.642
I didn't have a sore throat.

00:12:48.642 --> 00:12:51.520
I didn't have a cough or runny
nose or anything like that.

00:12:51.520 --> 00:12:54.231
It wasn't until
three months later

00:12:54.231 --> 00:12:56.817
I tested positive for HIV.

00:12:56.817 --> 00:12:59.695
I think the biggest thing
for talking to my parents

00:12:59.695 --> 00:13:02.281
about HIV was
fighting the stigma

00:13:02.281 --> 00:13:06.368
and changing whatever their
preconceived notions were about

00:13:06.368 --> 00:13:09.330
having a gay son with
HIV was going to be.

00:13:12.833 --> 00:13:13.834
- Andrew.

00:13:15.252 --> 00:13:17.213
- My junior year when I was 17

00:13:17.213 --> 00:13:19.381
is when I fully came
out of the closet

00:13:19.381 --> 00:13:22.760
and I actually came
out to my family first.

00:13:22.760 --> 00:13:26.263
The response from my
mom was, "Are you sure?"

00:13:26.263 --> 00:13:28.432
And I was like,
"I'm pretty sure."

00:13:28.432 --> 00:13:31.852
And then she said, "Have you
ever been with a woman before?"

00:13:31.852 --> 00:13:33.771
And I was like, "No."

00:13:33.771 --> 00:13:35.731
And she's like, "Well, how do
you know you wouldn't like it?

00:13:35.731 --> 00:13:37.399
And so then I asked
her the same question,

00:13:37.399 --> 00:13:39.151
like "Have you ever been
with a woman before?"

00:13:39.151 --> 00:13:40.861
And she's like, "No."

00:13:40.861 --> 00:13:43.155
And I was like, "Well, how do
you know you don't like it?"

00:13:43.155 --> 00:13:46.200
So she was
surprisingly surprised.

00:13:46.200 --> 00:13:49.370
I mean, growing up as
really into the arts,

00:13:49.370 --> 00:13:52.665
singing, doing theater,
going to an arts high school,

00:13:52.665 --> 00:13:54.750
I had all of the telltale signs

00:13:54.750 --> 00:13:57.169
of you're raising a
little homosexual.

00:13:57.169 --> 00:13:59.421
- It didn't change anything.

00:13:59.421 --> 00:14:00.548
You know?

00:14:00.548 --> 00:14:02.424
Did I suspect it? No.

00:14:02.424 --> 00:14:04.802
I thought I was gonna
have the only straight guy

00:14:04.802 --> 00:14:08.722
interested in musical
theater, wrong. (laughing)

00:14:08.722 --> 00:14:09.890
- No pain?

00:14:10.724 --> 00:14:11.684
- Nope.

00:14:14.353 --> 00:14:16.564
- So all you have to do is rest.

00:14:17.481 --> 00:14:19.358
- I think I can do that.

00:14:19.358 --> 00:14:21.277
- So this asks a
lot of the patient

00:14:21.277 --> 00:14:24.405
because they're taking a risk
that they don't have to take.

00:14:24.405 --> 00:14:28.409
This population of
patients is very altruistic

00:14:28.409 --> 00:14:31.495
and it's a humanitarian
gesture that they make

00:14:31.495 --> 00:14:34.206
when they subject
themselves to the risk

00:14:34.206 --> 00:14:36.417
of a stem cell transplantation.

00:14:36.417 --> 00:14:38.711
Because these stem
cells don't go in

00:14:38.711 --> 00:14:40.880
a regular old blood transfusion.

00:14:40.880 --> 00:14:44.466
You have to basically prepare
the person to receive them.

00:14:44.466 --> 00:14:48.846
You have to make space
to receive a stem cell.

00:14:48.846 --> 00:14:53.267
That's a euphemism for giving
the person some chemotherapy

00:14:53.267 --> 00:14:56.520
that decreases the number of
cells in their bone marrow.

00:14:56.520 --> 00:14:59.523
When you give a
person chemotherapy,
they're taking a risk,

00:14:59.523 --> 00:15:01.817
there could be
infections that occur,

00:15:01.817 --> 00:15:04.570
there can be damages
to their normal DNA

00:15:04.570 --> 00:15:07.323
that may appear 20 years later.

00:15:07.323 --> 00:15:10.784
- When he first asked
me to be his caregiver

00:15:10.784 --> 00:15:13.871
through this program,
it was a tender question

00:15:13.871 --> 00:15:16.415
because I had just
cared for my mother

00:15:16.415 --> 00:15:17.666
at the end of her life.

00:15:17.666 --> 00:15:19.209
She had lymphoma.

00:15:19.209 --> 00:15:19.877
So

00:15:20.961 --> 00:15:24.548
it's nerve wracking for me.

00:15:24.548 --> 00:15:26.926
I'm very proud of him and...

00:15:30.304 --> 00:15:32.806
I don't know, I hope it
doesn't make him sick.

00:15:32.806 --> 00:15:36.477
- This was my opportunity to
do something bigger than myself

00:15:36.477 --> 00:15:39.521
and sacrifice a week now

00:15:39.521 --> 00:15:43.734
and four weeks later of
my precious, precious time

00:15:43.734 --> 00:15:47.321
to do something that
could potentially save

00:15:47.321 --> 00:15:49.823
thousands of lives
in the future.

00:15:49.823 --> 00:15:51.450
- Is it scary?

00:15:52.493 --> 00:15:53.911
- It's not scary.

00:15:53.911 --> 00:15:56.455
It's just, I feel
like it's important

00:15:59.667 --> 00:16:01.627
for there to be a cure.

00:16:03.003 --> 00:16:05.339
- Usually when you get
infected with a virus

00:16:05.339 --> 00:16:08.676
what happens is your immune
system sends its soldiers

00:16:08.676 --> 00:16:10.511
out to attack that virus.

00:16:10.511 --> 00:16:13.847
And in a matter of days or
weeks, the infection goes away.

00:16:15.349 --> 00:16:17.643
One of the insidious
things that HIV does is

00:16:17.643 --> 00:16:20.020
the very soldiers that
are coming after it,

00:16:20.020 --> 00:16:22.022
the so-called CD4 T cells,

00:16:22.022 --> 00:16:24.984
these are the cells
that HIV infects

00:16:24.984 --> 00:16:27.778
and it stops them
doing their job.

00:16:27.778 --> 00:16:32.700
But about 1% of people
naturally have immune cells

00:16:32.700 --> 00:16:34.910
that are resistant to HIV.

00:16:34.910 --> 00:16:37.579
We call them CCR5 negative.

00:16:37.579 --> 00:16:42.584
And I heard about a
new technology, these
man-made proteins

00:16:44.003 --> 00:16:45.546
and when they bind
to the CCR5 gene,

00:16:45.546 --> 00:16:47.798
they act like genetic scissors

00:16:47.798 --> 00:16:50.426
and they cut the gene
and they damage it.

00:16:50.426 --> 00:16:52.636
So everything started
to come together,

00:16:52.636 --> 00:16:56.056
the idea that we could take
stem cells out of a patient,

00:16:56.056 --> 00:17:00.394
we could treat them to make
those stem cells CCR5 negative.

00:17:00.394 --> 00:17:03.981
Those CCR5 negative
stem cells will start to

00:17:03.981 --> 00:17:07.359
make an immune system
in the patient,

00:17:07.359 --> 00:17:08.944
everything will be normal,

00:17:08.944 --> 00:17:11.697
apart from the fact
the new immune cells

00:17:11.697 --> 00:17:13.907
will be CCR5 negative as well

00:17:13.907 --> 00:17:16.618
and they will be
resistant to HIV.

00:17:21.040 --> 00:17:23.751
- Did you have it it
on last time, Cheryl?

00:17:23.751 --> 00:17:25.419
- My hat?
- Yeah.

00:17:25.419 --> 00:17:26.587
- I don't know what I
was wearing last time.

00:17:26.587 --> 00:17:27.921
- All right.

00:17:27.921 --> 00:17:29.923
Be careful, this
is hard plastic.

00:17:29.923 --> 00:17:31.759
- Should I take your hat?
- Sure.

00:17:31.759 --> 00:17:33.469
- Sure, please.

00:17:33.469 --> 00:17:35.095
A couple of warm blankets.
- Okay good.

00:17:35.095 --> 00:17:37.556
- And do you want
something for your head?

00:17:37.556 --> 00:17:39.433
- Yeah, 'cause my
head gets cold.

00:17:39.433 --> 00:17:41.769
- Okay, Cheryl, we're
gonna get started.

00:17:56.575 --> 00:18:00.120
- So I got diagnosed
in January of 2016,

00:18:00.120 --> 00:18:02.873
so my daughter had
just turned six.

00:18:02.873 --> 00:18:04.124
You can do that.

00:18:04.124 --> 00:18:06.126
You want to start with that pan?

00:18:06.126 --> 00:18:08.003
You know how big to make 'em?

00:18:08.003 --> 00:18:10.506
Cause these are cookies that
should be a little bit bigger.

00:18:10.506 --> 00:18:12.591
That's why they're
monster cookies.

00:18:12.591 --> 00:18:14.510
And they're a little
tough, aren't they?

00:18:14.510 --> 00:18:16.512
Whoa! (laughing)

00:18:16.512 --> 00:18:17.638
whoops.

00:18:22.518 --> 00:18:24.978
The first thing
that I noticed was

00:18:24.978 --> 00:18:28.857
that I had a large mass
on my my right breast

00:18:28.857 --> 00:18:33.862
and really was thinking that
it wasn't anything at all

00:18:34.822 --> 00:18:36.490
and was quite shocked

00:18:36.490 --> 00:18:39.910
when I learned that
it was lymphoma.

00:18:41.161 --> 00:18:43.163
- You can have
whichever one you want.

00:18:43.163 --> 00:18:45.457
- How was it?

00:18:45.457 --> 00:18:46.959
- Mm.
- Yeah, was it was okay?

00:18:46.959 --> 00:18:48.544
- Doughy.

00:18:48.544 --> 00:18:49.670
- They're really best
when they're warm.

00:18:49.670 --> 00:18:51.130
- That one's a little hot.

00:18:51.130 --> 00:18:53.966
The doctor said diffuse
large B-cell lymphoma

00:18:53.966 --> 00:18:57.553
is fast growing and it's
an aggressive cancer

00:18:57.553 --> 00:18:59.513
but it's very treatable.

00:18:59.513 --> 00:19:02.182
So I went through a couple
of rounds of chemotherapy

00:19:02.182 --> 00:19:04.810
and had come back clear.

00:19:04.810 --> 00:19:07.437
I was back at work
for about a month.

00:19:07.437 --> 00:19:09.189
Did something, pulled a muscle,

00:19:09.189 --> 00:19:10.899
and it was right in my ribs.

00:19:10.899 --> 00:19:14.611
So I'm thinking one,
two weeks later,

00:19:14.611 --> 00:19:17.698
that really this pain
should be disappearing.

00:19:17.698 --> 00:19:21.076
So I went through the
ultrasound mammograms again

00:19:21.076 --> 00:19:23.036
and then something showed up.

00:19:24.830 --> 00:19:28.000
Not only had it come back,
but it showed only one lesion

00:19:28.000 --> 00:19:30.878
on my breast, but that
there were quite a few spots

00:19:30.878 --> 00:19:33.046
in my right lung and
a few on my left.

00:19:33.046 --> 00:19:36.049
Being cancer-free only a
few months made me think

00:19:36.049 --> 00:19:38.969
maybe my cancer
wasn't really gone.

00:19:38.969 --> 00:19:41.763
It was pretty devastating
to think about that.

00:19:41.763 --> 00:19:45.517
And it seemed like it
was a death sentence.

00:19:47.060 --> 00:19:49.605
- Proposition 71 would
authorize the state to raise

00:19:49.605 --> 00:19:51.857
billions of dollars
for stem cell research.

00:19:51.857 --> 00:19:53.734
- In California,

00:19:53.734 --> 00:19:56.236
voters approved spending $3
billion on stem cell research.

00:19:56.236 --> 00:19:59.072
- Voters here in California
approve one of the largest

00:19:59.072 --> 00:20:01.033
scientific endeavors
in all of history.

00:20:01.033 --> 00:20:02.743
- It's California,
which isn't waiting

00:20:02.743 --> 00:20:04.578
on the federal government

00:20:04.578 --> 00:20:06.205
to make up its mind
about stem cell research.

00:20:06.205 --> 00:20:09.124
- We have the capacity to really
move this research forward

00:20:09.124 --> 00:20:11.001
with life saving cures.

00:20:11.001 --> 00:20:13.795
Californians know that can
change the future of medicine.

00:20:13.795 --> 00:20:16.048
- Robert Klein who
heads the organization

00:20:16.048 --> 00:20:18.091
that will decide how
California spends

00:20:18.091 --> 00:20:19.968
its $3 billion stem cell fund

00:20:19.968 --> 00:20:22.721
says the research can't
wait for Washington.

00:20:22.721 --> 00:20:25.682
- In the history of
life on this planet,

00:20:25.682 --> 00:20:27.768
the history of science,

00:20:27.768 --> 00:20:32.064
we've never been able to
create a single human cell.

00:20:32.064 --> 00:20:35.609
With this stem cell therapies,

00:20:35.609 --> 00:20:39.279
we can create a
replacement for an organ.

00:20:39.279 --> 00:20:42.741
We can repair a heart.

00:20:42.741 --> 00:20:46.245
This is a magnitude
that it will transform

00:20:46.245 --> 00:20:48.914
medicine as you know it.

00:20:48.914 --> 00:20:51.208
So it's a $6 billion vote.

00:20:51.208 --> 00:20:53.585
This public
corporation was set up.

00:20:53.585 --> 00:20:55.712
It's called the
California Institute

00:20:55.712 --> 00:20:57.798
of Regenerative Medicine, CIRM.

00:20:57.798 --> 00:21:00.092
Now there are 42 human trials

00:21:00.092 --> 00:21:02.261
and California was the place,

00:21:04.054 --> 00:21:06.932
the only real place where
we could get the scale

00:21:06.932 --> 00:21:10.560
and the momentum to make it real

00:21:10.560 --> 00:21:13.313
in the lifetime of our
children and our families.

00:21:15.148 --> 00:21:20.112
♪ Daddy finger, daddy
finger, where are you ♪

00:21:20.112 --> 00:21:23.782
♪ Here I am, here I am

00:21:23.782 --> 00:21:26.994
♪ How do you do

00:21:26.994 --> 00:21:29.788
- When I gave birth to her,

00:21:29.788 --> 00:21:34.793
right when she came out,
she had a fever of 104.

00:21:36.128 --> 00:21:38.171
A newborn baby with
a fever of 104.

00:21:38.171 --> 00:21:41.174
And it was just this thing
over and over and over,

00:21:41.174 --> 00:21:44.970
she kept getting sick
and I kept wondering,

00:21:44.970 --> 00:21:47.639
Like why does she
keep getting sick?

00:21:47.639 --> 00:21:49.850
Like what's wrong with my baby?

00:21:49.850 --> 00:21:51.351
This one?

00:21:52.978 --> 00:21:56.982
They properly
diagnosed her with SCID

00:21:56.982 --> 00:22:00.193
which is severe combined
immunodeficiency.

00:22:00.193 --> 00:22:02.863
She was born with
no immune system.

00:22:02.863 --> 00:22:05.615
We almost lost Ava

00:22:05.615 --> 00:22:08.035
because we didn't
know she needed

00:22:08.035 --> 00:22:10.746
a life-saving bone
marrow transplant.

00:22:10.746 --> 00:22:12.706
It was so scary.

00:22:13.874 --> 00:22:16.126
I think if we waited any longer,

00:22:16.126 --> 00:22:19.004
we would have lost our baby.

00:22:19.004 --> 00:22:23.300
And then Ava went through
chemotherapy treatments.

00:22:23.300 --> 00:22:26.386
It did take a lot out
on her, her little body.

00:22:26.386 --> 00:22:28.221
Put these on, okay?

00:22:28.221 --> 00:22:30.891
She did go through the nausea.

00:22:30.891 --> 00:22:32.642
She lost her hair.

00:22:32.642 --> 00:22:36.772
She was just very
sick, it's so painful.

00:22:36.772 --> 00:22:39.858
So we went through the first
bone marrow transplant.

00:22:39.858 --> 00:22:42.277
We spent eight months
in the hospital.

00:22:42.277 --> 00:22:46.406
She was six months when she
got the bone marrow transplant.

00:22:46.406 --> 00:22:48.200
When we're in the hospital

00:22:48.200 --> 00:22:50.410
she wasn't allowed
to leave her room.

00:22:50.410 --> 00:22:53.705
She wasn't well enough to
even step outside the door.

00:22:53.705 --> 00:22:56.208
They just had to keep
her strictly isolated.

00:22:57.084 --> 00:22:58.752
- Whoa!

00:23:00.087 --> 00:23:03.256
- The nurses and doctors
would have to gown up

00:23:03.256 --> 00:23:05.342
from head to toe to come in.

00:23:05.342 --> 00:23:07.135
- Oh, high five.

00:23:07.135 --> 00:23:09.679
Wow, you wanna do
one more good one?

00:23:09.679 --> 00:23:13.058
- You're in this room
every day for eight months

00:23:13.058 --> 00:23:15.185
and it was really hard.

00:23:16.103 --> 00:23:17.771
Go ahead, do vitals.

00:23:18.730 --> 00:23:19.773
Good job.

00:23:21.441 --> 00:23:23.443
You gotta open wide.
- Ready?

00:23:24.444 --> 00:23:26.113
Thank you.

00:23:26.113 --> 00:23:28.031
- Well after the transplant,

00:23:28.031 --> 00:23:30.117
she's still developed infections

00:23:30.117 --> 00:23:32.828
and viruses,
bacterial infections.

00:23:32.828 --> 00:23:36.331
She developed graft
vs host disease.

00:23:36.331 --> 00:23:39.793
It just takes over internally,

00:23:39.793 --> 00:23:42.921
just fighting so
hard for her life.

00:23:44.339 --> 00:23:46.800
And then at that time I'm like

00:23:46.800 --> 00:23:50.303
isn't the bone marrow transplant
working or is it failing?

00:23:50.303 --> 00:23:51.972
What's happening?

00:23:55.392 --> 00:23:58.478
(birds chirping)

00:23:58.478 --> 00:24:00.814
- When we got into the hospital,

00:24:00.814 --> 00:24:03.733
we went to the emergency
room, waiting room

00:24:03.733 --> 00:24:06.153
and there, my two parents
were sitting there

00:24:06.153 --> 00:24:07.988
They had tears in their eyes

00:24:07.988 --> 00:24:09.990
and just came up and
hugged me and my brother.

00:24:09.990 --> 00:24:12.909
And my dad said, "I know
Ryan can't feel his legs,

00:24:12.909 --> 00:24:16.121
but I think everything
else is fine."

00:24:16.121 --> 00:24:19.249
And the doctor looked at my
dad in the eyes and said,

00:24:19.249 --> 00:24:22.210
"Sir, your son is paralyzed
from the chest down."

00:24:22.210 --> 00:24:24.087
And I ran out of the room.

00:24:24.087 --> 00:24:26.339
A few of Ryan's friends
had been outside

00:24:26.339 --> 00:24:28.175
in the waiting room.

00:24:28.175 --> 00:24:30.093
And I remember they
chased after me were like,

00:24:30.093 --> 00:24:31.928
"Kenzie, Kenzie,
what did they say?"

00:24:31.928 --> 00:24:33.346
And I just screamed.

00:24:33.346 --> 00:24:35.474
And I remember just
dropping to the floor

00:24:35.474 --> 00:24:37.851
because I could not
believe what I just heard

00:24:37.851 --> 00:24:40.395
come out of the doctor's mouth.

00:24:40.395 --> 00:24:42.939
(soft music)

00:24:44.983 --> 00:24:47.527
- All right, so we got
everything we need, right?

00:24:47.527 --> 00:24:50.906
- We had been Snapchatting
that day that it happened.

00:24:50.906 --> 00:24:53.366
And he actually Snapchatted
me and said like,

00:24:53.366 --> 00:24:55.368
"I'm about to jump in the pool."

00:24:55.368 --> 00:24:58.288
And then that was like the
last Snapchat I received.

00:24:58.288 --> 00:25:01.374
And I Snapchatted him back
and then he never answered it,

00:25:01.374 --> 00:25:02.959
so then I was like, hum.

00:25:02.959 --> 00:25:04.878
And then that's
when I got the call

00:25:04.878 --> 00:25:06.546
like 20 minutes after that.

00:25:06.546 --> 00:25:09.049
(soft music)

00:25:10.842 --> 00:25:13.345
- We now know Ryan Custer
will head to Chicago

00:25:13.345 --> 00:25:17.140
to be considered for stem
cell study at Rush University.

00:25:22.854 --> 00:25:26.149
- Okay, who's timing me,
telling me when to start?

00:25:28.443 --> 00:25:29.986
Tell me when.

00:25:31.404 --> 00:25:32.989
Okay, starting.

00:25:32.989 --> 00:25:35.909
Give me every 10
seconds, please.

00:25:35.909 --> 00:25:38.578
- There's a Dr. Fessler
at Rush University

00:25:38.578 --> 00:25:40.580
that's doing stem cell research.

00:25:40.580 --> 00:25:42.415
And they said, "Preliminarily,

00:25:42.415 --> 00:25:44.543
it sounds like he's
a fit for our study."

00:25:44.543 --> 00:25:46.962
Dr. Fessler called
me on the way home,

00:25:46.962 --> 00:25:50.173
Monday, I was coming home
going back to Cincinnati.

00:25:50.173 --> 00:25:53.593
And he said, "Even though
his injury was at C5,

00:25:53.593 --> 00:25:56.429
he actually tested
C4, which is worse."

00:25:56.429 --> 00:25:58.098
So he said,

00:25:58.098 --> 00:26:00.350
"We have to apply for an
exemption with the FDA."

00:26:00.350 --> 00:26:02.143
So yeah, it was devastating.

00:26:02.143 --> 00:26:03.562
I called Kim, I mean,

00:26:03.562 --> 00:26:05.272
'cause that's our only hope.

00:26:05.272 --> 00:26:08.024
I mean, if that doesn't happen,

00:26:08.024 --> 00:26:11.194
then he's like this
the rest of his life.

00:26:11.194 --> 00:26:14.281
But you pin all your
hopes on this one thing

00:26:14.281 --> 00:26:17.075
and then it could get
ripped away from you.

00:26:17.075 --> 00:26:19.244
Finally, Thursday
morning, he called

00:26:19.244 --> 00:26:21.454
and said Ryan had been accepted.

00:26:21.454 --> 00:26:24.291
So that was unbelievable,
unbelievable news.

00:26:28.211 --> 00:26:30.005
- Oh, it looks good.

00:26:31.423 --> 00:26:35.135
- When you meet patients
that are just paralyzed

00:26:35.135 --> 00:26:38.013
from the neck
down, such as Ryan,

00:26:38.013 --> 00:26:39.889
everybody's still in shock.

00:26:39.889 --> 00:26:42.642
Nobody can believe something
like this has happened.

00:26:42.642 --> 00:26:47.897
And you're there to tell
them it has happened

00:26:47.897 --> 00:26:51.651
and then say this
is the way it is

00:26:51.651 --> 00:26:53.987
and that's all that's to it.

00:26:55.614 --> 00:26:59.075
It is in many ways, that's
a harder conversation

00:27:00.452 --> 00:27:03.413
to have with a patient
and their loved ones

00:27:03.413 --> 00:27:06.625
than to tell them
they've got cancer.

00:27:06.625 --> 00:27:10.670
Cancer we've made
great progress in now.

00:27:10.670 --> 00:27:13.048
We can extend life.

00:27:13.048 --> 00:27:16.926
In these situations,
we could do nothing.

00:27:21.139 --> 00:27:23.642
- I'm a little nervous, but

00:27:23.642 --> 00:27:25.935
Like my dad always pushed me.

00:27:25.935 --> 00:27:28.521
Never give up,
never stop fighting,

00:27:28.521 --> 00:27:32.567
so that kind of
played into this.

00:27:32.567 --> 00:27:35.612
They've been here for
me every step of the way

00:27:35.612 --> 00:27:38.156
not just my immediate family,

00:27:38.156 --> 00:27:41.201
but my teammates
from Wright State,

00:27:41.201 --> 00:27:42.452
they've been there.

00:27:42.452 --> 00:27:44.037
When I was in Cincinnati,

00:27:44.037 --> 00:27:45.580
they'd drive down every day.

00:27:45.580 --> 00:27:47.207
And my friends from Cincinnati,

00:27:47.207 --> 00:27:49.376
they were every
second of the day,

00:27:49.376 --> 00:27:51.378
as much as they possibly could.

00:27:51.378 --> 00:27:55.048
So it just, it feels
good to have that support

00:27:55.048 --> 00:27:58.259
knowing that those
people are behind you,

00:27:58.259 --> 00:28:01.221
fighting for you as much
as they possibly can.

00:28:01.221 --> 00:28:04.057
I'm just hoping for
the best really.

00:28:04.057 --> 00:28:06.393
(moving music)

00:28:20.615 --> 00:28:23.201
- Lots of people in
the front please.

00:28:24.244 --> 00:28:26.413
Okay. I'm Irv Weissman.

00:28:26.413 --> 00:28:28.581
I'm head of the
Stem Cell Institute

00:28:28.581 --> 00:28:33.086
and I was the first director
of the immunology program

00:28:33.086 --> 00:28:35.547
before some of you were born.

00:28:35.547 --> 00:28:38.133
Every true stem cell therapy

00:28:38.133 --> 00:28:41.010
where you transplant
the tissue stem cell

00:28:41.010 --> 00:28:44.264
because they always, for life
make just the right amount

00:28:44.264 --> 00:28:48.017
of more of themselves
to keep it steady.

00:28:48.017 --> 00:28:52.313
If it's a curative therapy,
you do it once for life.

00:28:53.732 --> 00:28:56.192
We were all taught that
pharmaceutical companies

00:28:56.192 --> 00:28:58.945
and biotech translate
our discoveries.

00:28:58.945 --> 00:29:02.031
But if you're on the board
of directors of the company,

00:29:02.031 --> 00:29:05.160
you have one mission,
make a profit.

00:29:05.160 --> 00:29:08.580
And if you can make more money
faster out of something else

00:29:08.580 --> 00:29:10.290
then this, you would do it.

00:29:10.290 --> 00:29:12.667
Pharma is so clever.

00:29:12.667 --> 00:29:15.336
It wants to keep chronic drugs

00:29:15.336 --> 00:29:17.547
that you remember
to take every day.

00:29:17.547 --> 00:29:21.050
So they equate themselves
with every other company

00:29:21.050 --> 00:29:23.636
but they're part
of a public trust.

00:29:23.636 --> 00:29:26.473
They're the only ones who
deliver the therapies.

00:29:26.473 --> 00:29:30.477
So we began
transplants at Stanford

00:29:31.686 --> 00:29:35.440
of women with metastatic
breast cancer.

00:29:35.440 --> 00:29:38.526
So it was beyond the breast,
beyond the lymph nodes,

00:29:38.526 --> 00:29:41.488
in the bones and
the lung, the liver,

00:29:41.488 --> 00:29:44.491
we had a hundred microliters
of a clear fluid.

00:29:44.491 --> 00:29:48.828
We knew that when people give
back bone marrow to a patient,

00:29:48.828 --> 00:29:51.331
they were giving back cancer.

00:29:51.331 --> 00:29:53.541
We purified the stem cells

00:29:53.541 --> 00:29:57.253
and showed there were no
cancer cells there at all.

00:29:57.253 --> 00:29:59.506
We said, okay, we'll
transplant these

00:29:59.506 --> 00:30:02.759
back into women who have
metastatic breast cancer.

00:30:02.759 --> 00:30:05.345
No hope of any
therapy curing them.

00:30:05.345 --> 00:30:08.264
We cured one third of the women.

00:30:08.264 --> 00:30:11.351
The first patient, she's
still teaching school now

00:30:11.351 --> 00:30:13.436
21 years later.

00:30:13.436 --> 00:30:14.646
- Hi.
- Hi, how are you.

00:30:14.646 --> 00:30:15.647
- Good, good.

00:30:15.647 --> 00:30:16.606
- It's great to see you.

00:30:16.606 --> 00:30:18.191
- You too.

00:30:18.191 --> 00:30:19.776
- Please sit down.
- Thank you.

00:30:19.776 --> 00:30:22.529
My cancer had spread
all over my spine,

00:30:22.529 --> 00:30:25.490
all over my pelvic bone.

00:30:25.490 --> 00:30:30.495
And it was just pretty much
everywhere in my bones.

00:30:31.871 --> 00:30:33.748
And I decided to
go for the trial.

00:30:33.748 --> 00:30:38.419
- They brought out a little
tube with your pure stem cells

00:30:38.419 --> 00:30:41.130
and it looked like
clear fluid to me.

00:30:41.130 --> 00:30:43.341
And we were scared to death

00:30:43.341 --> 00:30:46.261
that you, the first
person in the world to get

00:30:46.261 --> 00:30:49.472
a pure blood forming
stem cell transplant,

00:30:49.472 --> 00:30:51.599
10 days later, your
white cells back,

00:30:51.599 --> 00:30:54.686
a few days after that,
your platelets were back.

00:30:55.895 --> 00:30:57.814
21 years later,

00:30:59.357 --> 00:31:02.235
there's no doubt
that you were cured.

00:31:02.235 --> 00:31:03.736
- It's amazing.

00:31:08.283 --> 00:31:10.702
- I thought, okay, it's natural.

00:31:10.702 --> 00:31:14.372
Everybody will see this
and they'll move forward.

00:31:14.372 --> 00:31:16.708
But when they got
a different product

00:31:16.708 --> 00:31:19.752
that would make more money
faster, shut it all down.

00:31:19.752 --> 00:31:22.463
The moment when
they shut it down,

00:31:24.257 --> 00:31:25.675
(exhales)

00:31:25.675 --> 00:31:28.428
I thought there were
just a bunch of fools.

00:31:28.428 --> 00:31:30.179
They went back to what

00:31:30.179 --> 00:31:33.892
they were most
comfortable with, pills.

00:31:33.892 --> 00:31:36.686
And pills you sell every day

00:31:36.686 --> 00:31:39.272
'cause you have to
give them every day.

00:31:39.272 --> 00:31:41.649
They were business people.

00:31:41.649 --> 00:31:43.318
They weren't scientists.

00:31:43.318 --> 00:31:45.361
They weren't doctors for sure.

00:31:45.361 --> 00:31:47.655
They forgot the pledge

00:31:47.655 --> 00:31:50.366
that what you do is
to advance medicine

00:31:50.366 --> 00:31:53.494
through research for
the health of people.

00:31:53.494 --> 00:31:57.916
In the US alone, about
50,000 women every year

00:31:57.916 --> 00:32:01.628
graduate to metastatic
breast cancer,

00:32:01.628 --> 00:32:03.630
spread throughout the body.

00:32:03.630 --> 00:32:06.299
They have no chance.

00:32:06.299 --> 00:32:09.886
This should have
happened since 2000.

00:32:09.886 --> 00:32:14.891
So if you would saved
a third of the women,

00:32:16.434 --> 00:32:20.313
so a third of 50,000
is 13 to 14,000 a year,

00:32:20.313 --> 00:32:23.358
times 15 years,

00:32:23.358 --> 00:32:28.363
225,000 people in
the US alone died.

00:32:29.447 --> 00:32:31.783
So that's just breast cancer.

00:32:31.783 --> 00:32:33.868
(soft music)

00:32:33.868 --> 00:32:38.873
And you have to ask if the
biotech and drug companies

00:32:38.873 --> 00:32:41.793
aren't gonna take on the
health of the patient

00:32:41.793 --> 00:32:44.754
as their first goal and
the profit of their company

00:32:44.754 --> 00:32:46.339
as the second goal,

00:32:46.339 --> 00:32:48.257
who's gonna do it?

00:32:50.677 --> 00:32:52.387
- Oh... Oh, there he is.

00:32:52.387 --> 00:32:55.348
There he is, he's
sitting right there.

00:32:55.348 --> 00:32:56.766
- Oh my gosh.

00:32:56.766 --> 00:32:58.267
Do you see Carolyn?

00:32:58.267 --> 00:32:59.769
Hi.
- Hey buddy.

00:33:00.853 --> 00:33:02.021
Hey.

00:33:02.021 --> 00:33:03.856
He just went like this.

00:33:03.856 --> 00:33:05.692
- Yeah, it's really short.

00:33:05.692 --> 00:33:06.859
It's just a sprint.

00:33:06.859 --> 00:33:08.319
- Oh, this is his race.

00:33:08.319 --> 00:33:09.737
Come on, honey.

00:33:09.737 --> 00:33:11.364
- My husband and
I, we are a team.

00:33:11.364 --> 00:33:12.949
When I met my husband,

00:33:12.949 --> 00:33:15.702
it was like an epic novel.

00:33:15.702 --> 00:33:17.578
Come on buddy, you can do it.

00:33:17.578 --> 00:33:19.372
You can do it Alessandro.

00:33:19.372 --> 00:33:20.999
Come on, Alessandro!

00:33:22.542 --> 00:33:25.420
When we finally did
have kids, we had twins.

00:33:25.420 --> 00:33:29.632
But there was a point where
we almost lost that pregnancy.

00:33:29.632 --> 00:33:32.468
I went into labor at 23 weeks.

00:33:32.468 --> 00:33:34.387
The doctor was honest.

00:33:34.387 --> 00:33:37.598
He said, "I want you right
now to prepare to grieve.

00:33:37.598 --> 00:33:39.434
That's what I want you to do."

00:33:39.434 --> 00:33:41.602
That was, that's really hard.

00:33:41.602 --> 00:33:43.062
That's, that's,

00:33:43.062 --> 00:33:45.523
that's not something
I was ready to do.

00:33:45.523 --> 00:33:47.025
I didn't want to grieve.

00:33:47.025 --> 00:33:49.736
And we prayed and we said,

00:33:49.736 --> 00:33:53.906
"God, whatever shape you want
to give these kids to us,

00:33:53.906 --> 00:33:55.533
we will take them."

00:33:55.533 --> 00:33:57.452
- Come on, Alessandro!
- Woo!

00:33:57.452 --> 00:34:00.329
- Alessandro, let's go!

00:34:00.329 --> 00:34:03.374
- Come on Alessandro,
you can do it!

00:34:03.374 --> 00:34:04.667
(whistle blows)

00:34:04.667 --> 00:34:07.670
(audience cheering)

00:34:07.670 --> 00:34:09.672
Come on, buddy!

00:34:09.672 --> 00:34:12.383
Woo! Go buddy, go!

00:34:13.509 --> 00:34:16.512
Come on!

00:34:16.512 --> 00:34:20.933
(audience cheering
and applauding)

00:34:23.936 --> 00:34:26.606
Awesome job, awesome job.

00:34:26.606 --> 00:34:28.691
Give me high five.

00:34:28.691 --> 00:34:30.777
You did it!

00:34:30.777 --> 00:34:33.780
Our son Alessandro
and our daughter Milan

00:34:33.780 --> 00:34:35.698
were two micro premies

00:34:35.698 --> 00:34:38.576
and Alessandro just
seemed more fragile.

00:34:38.576 --> 00:34:41.120
He ended up with a
brain hemorrhage.

00:34:41.120 --> 00:34:42.747
I love you, buddy.

00:34:42.747 --> 00:34:44.415
- Hey, we're very
proud of you, buddy.

00:34:44.415 --> 00:34:46.876
- But we were just in a
mode of, you know what?

00:34:46.876 --> 00:34:48.503
We're gonna let this go

00:34:48.503 --> 00:34:51.130
and we're gonna allow
God to work through this

00:34:51.130 --> 00:34:54.008
because it's completely
out of our control.

00:35:00.598 --> 00:35:02.892
- Guys it's basically
just telling you

00:35:02.892 --> 00:35:05.061
that we're gonna collect
the white blood cells

00:35:05.061 --> 00:35:07.480
and then everything
goes back to you.

00:35:07.480 --> 00:35:10.525
And you know, there's always
a risk in every procedure

00:35:10.525 --> 00:35:11.984
and you know the risks.

00:35:11.984 --> 00:35:13.820
Are you having any
pain right now?

00:35:13.820 --> 00:35:15.655
- No.
- No?

00:35:15.655 --> 00:35:17.657
Any other issues or anything
you want to tell me?

00:35:17.657 --> 00:35:18.741
- No.
- You're good,

00:35:18.741 --> 00:35:20.618
you feel all right?

00:35:20.618 --> 00:35:23.871
- I feel 100% except for
the brain tumor in my head.

00:35:23.871 --> 00:35:25.832
Yeah. I remember meeting Kelly.

00:35:25.832 --> 00:35:28.543
At a party and I was
invited into a bathroom and-

00:35:28.543 --> 00:35:30.503
- That is not how we met.

00:35:30.503 --> 00:35:32.922
That is not how
we met. (laughing)

00:35:32.922 --> 00:35:35.842
- That's how we met
on a romantic basis,

00:35:35.842 --> 00:35:37.635
but it's not how
we met in general.

00:35:37.635 --> 00:35:40.012
We met at the state
attorney's office.

00:35:40.012 --> 00:35:42.056
We've been together
ever since, since what?

00:35:42.056 --> 00:35:43.766
- August of 2005.

00:35:43.766 --> 00:35:45.434
- Yeah, August of 2005,

00:35:45.434 --> 00:35:47.812
have two kids that are
growing very happy,

00:35:47.812 --> 00:35:49.021
happy, happy, happy.

00:35:49.021 --> 00:35:50.606
Love you.

00:35:50.606 --> 00:35:52.024
- Kiss.

00:35:52.024 --> 00:35:53.693
Ho, ho, ho.

00:35:53.693 --> 00:35:56.195
- Arr! Captain Hook.
- Captain Hook!

00:35:56.195 --> 00:35:57.864
- Arr!

00:35:57.864 --> 00:35:59.448
- We've known each
other for 12 years

00:35:59.448 --> 00:36:00.867
and we've been dealing
with it for 10.

00:36:00.867 --> 00:36:02.076
- For 10, yeah.

00:36:02.076 --> 00:36:03.744
- Yeah, a lot of
brain surgeries.

00:36:03.744 --> 00:36:04.912
A lot of chemo.

00:36:04.912 --> 00:36:06.539
- Man, yeah, yeah.

00:36:06.539 --> 00:36:10.209
My hope is that the
CAR T cells take over

00:36:10.209 --> 00:36:13.045
and they do what I need to do

00:36:13.045 --> 00:36:15.506
because otherwise I got,

00:36:16.841 --> 00:36:18.843
I don't know, a
short time to live.

00:36:23.723 --> 00:36:26.767
My kids and everything
else and my wife.

00:36:28.519 --> 00:36:30.980
(somber music)

00:36:35.902 --> 00:36:38.237
- I don't want to leave Daddy.

00:36:38.237 --> 00:36:40.156
- I don't want to
leave Daddy either

00:36:40.156 --> 00:36:42.783
but just remember

00:36:42.783 --> 00:36:44.911
it's always okay in the end

00:36:44.911 --> 00:36:47.580
and if it's not okay,
it's not the end.

00:36:47.580 --> 00:36:52.543
Okay? So everything's gonna
be okay in just a few hours.

00:36:53.544 --> 00:36:54.587
I love you.

00:36:54.587 --> 00:36:55.713
- Can I tell him?

00:36:55.713 --> 00:36:57.089
- Yeah. You can tell him.

00:36:58.174 --> 00:36:59.050
- Daddy.

00:37:00.593 --> 00:37:03.763
I'm gonna make you
a feel-better card.

00:37:03.763 --> 00:37:07.141
- That would be awesome,
that would be awesome.

00:37:07.141 --> 00:37:09.602
- While you're in surgery.

00:37:10.895 --> 00:37:12.772
(door chime rings)

00:37:12.772 --> 00:37:14.106
- How are you?

00:37:14.106 --> 00:37:16.025
Hey, how are you doing, doctor?

00:37:16.025 --> 00:37:17.693
- Doing okay?
- Good, good.

00:37:17.693 --> 00:37:19.278
- I saw your kids outside.

00:37:19.278 --> 00:37:21.239
Yeah they're
outside as well too.

00:37:21.239 --> 00:37:23.115
How are you feeling? Okay?

00:37:23.115 --> 00:37:25.534
- Yeah. I just didn't get
any sleep or much of it.

00:37:25.534 --> 00:37:26.827
- Oh really?

00:37:26.827 --> 00:37:28.287
- I'm nervous as hell.
- Oh really?

00:37:28.287 --> 00:37:30.122
So we're gonna go
over here, okay?

00:37:30.122 --> 00:37:31.958
- Yeah.

00:37:31.958 --> 00:37:34.585
- We'll make a little mark
here on the left side.

00:37:34.585 --> 00:37:35.628
- Okay.

00:37:37.088 --> 00:37:39.257
- No changes in your speech or?

00:37:39.257 --> 00:37:40.883
- No.

00:37:40.883 --> 00:37:43.135
- Strength is still
good, squeeze my hand.

00:37:43.135 --> 00:37:44.262
Good. Okay.

00:37:45.638 --> 00:37:47.265
I'm gonna go setup.
- Okay.

00:37:47.265 --> 00:37:49.225
- So we're gonna wake you up.

00:37:49.225 --> 00:37:50.559
You'll be fine.

00:37:50.559 --> 00:37:52.895
- Yeah, yeah, I should be.

00:37:52.895 --> 00:37:55.314
- Okay.
- All right, thank you.

00:38:00.695 --> 00:38:01.862
- Daddy.

00:38:03.656 --> 00:38:05.199
- How are you doing?

00:38:05.199 --> 00:38:08.035
- I'll see you in
about four hours.

00:38:08.035 --> 00:38:09.245
- You okay?

00:38:12.123 --> 00:38:13.708
We love you, man.

00:38:15.084 --> 00:38:17.253
All you have to do is relax.

00:38:17.253 --> 00:38:18.963
That's your only job.

00:38:20.339 --> 00:38:22.758
Okay? (crying)

00:38:25.261 --> 00:38:27.680
- I love you.
- I love you too.

00:38:31.017 --> 00:38:32.977
Give Daddy kisses.

00:38:34.145 --> 00:38:35.771
- Daddy.

00:38:35.771 --> 00:38:37.231
Daddy!

00:38:37.231 --> 00:38:39.025
- Give daddy kisses, okay?

00:38:42.028 --> 00:38:43.070
I love you.

00:38:44.196 --> 00:38:45.364
I love you.

00:38:46.657 --> 00:38:47.700
Okay.

00:39:08.262 --> 00:39:13.059
- So I met Dr. Forman
looking for a second opinion

00:39:13.059 --> 00:39:15.353
after being rediagnosed.

00:39:15.353 --> 00:39:18.689
He says, we have this clinical
trial with CAR T cells.

00:39:18.689 --> 00:39:22.234
We're gonna train 'em to
be super fighters for you

00:39:22.234 --> 00:39:24.945
and take care of any
microscopic cancer

00:39:24.945 --> 00:39:27.907
if there's anything left
after you have your chemo.

00:39:29.241 --> 00:39:30.701
- Hey.
- Hey.

00:39:30.701 --> 00:39:32.828
- How you doing?
- Good.

00:39:33.954 --> 00:39:35.873
Under the influence of Adavan.

00:39:35.873 --> 00:39:37.958
- Oh, getting started already.

00:39:37.958 --> 00:39:38.834
- Yeah.

00:39:40.294 --> 00:39:42.880
Just had a little bit
of a nervous stomach.

00:39:42.880 --> 00:39:45.257
- Yeah, did you
have any breakfast?

00:39:46.759 --> 00:39:49.178
- I had some cereal
and some eggs.

00:39:49.178 --> 00:39:51.764
- Have they given
you a timeframe

00:39:51.764 --> 00:39:54.058
when they're bringing
the T cells in?

00:39:54.058 --> 00:39:57.103
- I think I'm supposed to,
yeah, maybe about 10:30.

00:39:58.187 --> 00:40:00.189
- Is it the same kind of process

00:40:00.189 --> 00:40:02.775
where they have to thaw
out the stem cells,

00:40:02.775 --> 00:40:04.902
are they frozen up
when they come up here?

00:40:04.902 --> 00:40:06.320
- Yeah.

00:40:06.320 --> 00:40:08.697
(uplifting music)

00:40:10.324 --> 00:40:14.453
- My discussions about CAR T
cell began about 18 years ago

00:40:14.453 --> 00:40:17.289
and was based on ideas
of several scientists

00:40:17.289 --> 00:40:19.250
with whom I was working

00:40:19.250 --> 00:40:23.003
to see if we could
design immune cells,

00:40:23.003 --> 00:40:26.799
T cells that could
recognize and treat cancer.

00:40:26.799 --> 00:40:28.968
T-cells are part of
the immune system

00:40:28.968 --> 00:40:31.178
that recognize
viruses and infections

00:40:31.178 --> 00:40:33.806
and we believe based
on studies we've done

00:40:33.806 --> 00:40:37.309
that they participate in somehow
protecting us from cancer.

00:40:37.309 --> 00:40:40.062
Obviously when somebody
develops cancer,

00:40:40.062 --> 00:40:43.941
it means that those cells
didn't work to do that.

00:40:43.941 --> 00:40:47.987
So CAR T cell therapy for cancer
and leukemia in particular

00:40:47.987 --> 00:40:51.365
evolved to try to
reboot the immune system

00:40:51.365 --> 00:40:55.161
by engineering it to
do something that it
hadn't done before

00:40:55.161 --> 00:40:58.747
which is recognize the
cancer and wipe it out.

00:40:58.747 --> 00:41:01.000
- Through this process
called harvesting

00:41:01.000 --> 00:41:03.043
where they will take my T cells

00:41:03.043 --> 00:41:05.463
and then they need about a month

00:41:05.463 --> 00:41:08.215
to be able to to
train these T cells

00:41:08.215 --> 00:41:12.011
to be able to recognize
lymphoma and take care of it

00:41:12.011 --> 00:41:14.513
as if I had a common cold.

00:41:15.806 --> 00:41:18.309
The finest T cells. Yeah.

00:41:18.309 --> 00:41:20.019
(laughs)

00:41:22.396 --> 00:41:24.773
- And those T cells
that we engineer,

00:41:24.773 --> 00:41:26.525
they're very much
like stem cells,

00:41:26.525 --> 00:41:28.486
because we want to put them in

00:41:28.486 --> 00:41:32.323
hoping they're gonna be part
of that person's life forever.

00:41:32.323 --> 00:41:34.950
In the same way when
you have the flu

00:41:34.950 --> 00:41:37.870
and you recover from it,
your body remembers it,

00:41:37.870 --> 00:41:39.538
the immune system remembers it.

00:41:39.538 --> 00:41:41.290
And if it sees that virus again

00:41:41.290 --> 00:41:43.459
it's gonna react and
you won't get sick.

00:41:43.459 --> 00:41:47.213
Our idea is to engineer the
immune system for cancer.

00:41:47.213 --> 00:41:50.216
So if that cancer tries to
raise its ugly head again,

00:41:50.216 --> 00:41:53.135
part of your immune
system will whack it.

00:41:55.179 --> 00:41:59.183
- Yeah, hope that
this is something

00:41:59.183 --> 00:42:02.394
that's not just
beatable for now,

00:42:02.394 --> 00:42:06.190
'cause you hope in this life
that, as everybody does,

00:42:07.566 --> 00:42:11.320
that you're not looking
at facing these things

00:42:11.320 --> 00:42:14.907
until you're in your
70s, 80s, 90s, you know?

00:42:16.575 --> 00:42:20.538
And we have lots of plans
this family so it's,

00:42:21.914 --> 00:42:23.040
yeah.

00:42:23.040 --> 00:42:25.543
It's a life changer. So.

00:42:28.254 --> 00:42:30.381
Okay girls. Here
let me get you guys,

00:42:30.381 --> 00:42:32.383
are you done with your snacks?

00:42:32.383 --> 00:42:33.509
- No.
- You still want more?

00:42:33.509 --> 00:42:35.344
- No, I'm done with the snacks.

00:42:35.344 --> 00:42:37.388
- You are all done
with the snacks?

00:42:37.388 --> 00:42:39.014
- Yeah.

00:42:39.014 --> 00:42:40.474
- Do you want to do
a science experiment?

00:42:40.474 --> 00:42:41.892
- Yeah!
- All right. Go pick one.

00:42:41.892 --> 00:42:43.852
Go help your daddy pick one out.

00:42:43.852 --> 00:42:46.522
Hey, Violet's gonna pick
the first one, okay?

00:42:46.522 --> 00:42:48.941
It's says 29 experiments, here.

00:42:48.941 --> 00:42:51.527
What!
- 29 experiments.

00:42:51.527 --> 00:42:53.445
- Listen to the instructions.

00:42:53.445 --> 00:42:55.197
You have to be a scientist.

00:42:55.197 --> 00:42:57.324
You're gotta do
everything by the-

00:42:57.324 --> 00:43:00.286
[Steve] You got to observe
the scientific procedure.

00:43:00.286 --> 00:43:01.954
All right.

00:43:01.954 --> 00:43:03.872
Here's what we're
going to describe.

00:43:03.872 --> 00:43:05.541
Dear kids, do you
want to explore

00:43:05.541 --> 00:43:07.501
the wonders of
the natural world,

00:43:07.501 --> 00:43:10.629
learn about the plants,
experiment with air and water?

00:43:10.629 --> 00:43:11.589
- Yes.
- Yes.

00:43:11.589 --> 00:43:12.590
- Yes.
- Yes.

00:43:12.590 --> 00:43:14.425
- Let's get going

00:43:14.425 --> 00:43:17.052
and start in on this
awesome kit, experiments.

00:43:17.052 --> 00:43:18.470
(sighs)

00:43:18.470 --> 00:43:21.140
- Experiment kit.
- Let's get started

00:43:21.140 --> 00:43:25.436
and going in this... Um,

00:43:25.436 --> 00:43:28.314
- What?
- I'm having trouble reading.

00:43:28.314 --> 00:43:30.983
I don't know that I'm
having trouble reading,

00:43:30.983 --> 00:43:34.153
but I feel that I'm
having trouble reading.

00:43:34.153 --> 00:43:36.113
- You read everything
really good that time.

00:43:36.113 --> 00:43:37.114
- Yeah, it did.

00:43:37.114 --> 00:43:38.949
- It made sense.

00:43:38.949 --> 00:43:41.243
- It did but I paid close
attention to what I was reading

00:43:41.243 --> 00:43:42.661
and I didn't really realize

00:43:42.661 --> 00:43:44.663
what I was reading all
that much, you know?

00:43:44.663 --> 00:43:45.998
- Right, right, right.

00:43:45.998 --> 00:43:49.084
- I cried 13 million times.

00:43:49.084 --> 00:43:52.338
[Summer] 13 times!

00:43:52.338 --> 00:43:53.631
It was...

00:43:55.633 --> 00:43:58.302
- Terrible.
- Terrible?

00:43:58.302 --> 00:44:00.346
- Nothing was good about it.

00:44:00.346 --> 00:44:02.973
Nothing, zero percent.

00:44:02.973 --> 00:44:04.683
- Yeah.

00:44:04.683 --> 00:44:08.187
Was there any part that was
good at all about my gaining,

00:44:10.189 --> 00:44:12.191
surgery to make me better?

00:44:12.191 --> 00:44:16.195
- They made that
little brain tumor

00:44:16.195 --> 00:44:19.365
Pop right out of your head.

00:44:22.034 --> 00:44:23.535
I love you, Daddy.

00:44:28.165 --> 00:44:30.042
- So, with the surgery,

00:44:30.042 --> 00:44:32.586
I go remove as much of
the tumor as possible

00:44:32.586 --> 00:44:35.297
but then there's
microscopic tumor cells.

00:44:35.297 --> 00:44:38.175
So adding the CAR T
cells at that moment

00:44:38.175 --> 00:44:40.969
is like adding like
microscopic neurosurgeons

00:44:40.969 --> 00:44:43.722
who chase after those
small invasive cells,

00:44:43.722 --> 00:44:47.976
detect them and selectively
destroy them right then.

00:44:47.976 --> 00:44:51.063
And I think it'll be great
to have these little soldiers

00:44:51.063 --> 00:44:54.233
in your brain ready
to fight the cancers.

00:44:54.233 --> 00:44:58.487
I think that would be a
dream come true eventually.

00:44:58.487 --> 00:45:00.239
Hello, hello, how are you?
- Hello.

00:45:00.239 --> 00:45:01.240
- Doing okay?

00:45:01.240 --> 00:45:02.324
- Nice to see you.

00:45:02.324 --> 00:45:03.409
- You all right?
- Yeah.

00:45:03.409 --> 00:45:05.077
- Ready to do this?

00:45:05.077 --> 00:45:07.246
- Yeah, I guess so.
- All right.

00:45:07.246 --> 00:45:10.666
- Be a little poke, okay?

00:45:10.666 --> 00:45:11.667
Sorry.

00:45:13.335 --> 00:45:15.003
- Awesome.

00:45:15.003 --> 00:45:16.422
- That's the worst of it.
- Awesome.

00:45:16.422 --> 00:45:18.257
- How do you feel, okay?
- Okay.

00:45:18.257 --> 00:45:20.050
- Awesome.

00:45:21.218 --> 00:45:22.761
- Okay.

00:45:22.761 --> 00:45:25.431
I'm going to inject
the cells now, okay?

00:45:25.431 --> 00:45:27.599
Takes usually
about five minutes.

00:45:37.067 --> 00:45:39.319
- You're doing really,
really good, Steve.

00:45:39.319 --> 00:45:41.280
- Yeah.

00:45:41.280 --> 00:45:43.615
- I feel like that's
what everybody thinks.

00:45:45.701 --> 00:45:48.120
- All right, almost there.

00:45:48.120 --> 00:45:52.291
We're done, we're gonna
take the needle out. Okay.

00:45:53.542 --> 00:45:55.461
How you doing, you doing okay?

00:45:55.461 --> 00:45:57.504
- Yeah, yeah, yeah.
- All right.

00:45:58.756 --> 00:45:59.631
Yeah.

00:46:00.674 --> 00:46:02.342
Rest for like a couple hours.

00:46:02.342 --> 00:46:03.761
Two or three hours, okay?

00:46:03.761 --> 00:46:05.471
- Okay. Sounds
good, sounds good.

00:46:05.471 --> 00:46:07.473
- All right, see you.
- Thank you.

00:46:07.473 --> 00:46:10.225
- It was far less
gross than I expected.

00:46:10.225 --> 00:46:12.478
- I had a vision of...

00:46:12.478 --> 00:46:16.398
(imitating blasts of gunfire)

00:46:16.398 --> 00:46:19.401
- Yeah.
- All right we're going-- aah.

00:46:19.401 --> 00:46:21.320
- Yeah.

00:46:21.320 --> 00:46:24.490
I um, I didn't think it'd
be like that. (laughing)

00:46:45.511 --> 00:46:48.430
- The surgery on Ryan
went very routinely.

00:46:48.430 --> 00:46:52.226
We might see some
improvement by three months.

00:46:52.226 --> 00:46:55.646
I think it's more likely
that we'll see detectable

00:46:55.646 --> 00:46:58.440
improvement at six months.

00:46:58.440 --> 00:47:01.193
It's going to be baby
step by baby step.

00:47:01.193 --> 00:47:03.529
- So hold on tight
and we'll go on three.

00:47:03.529 --> 00:47:06.198
One, two, three.

00:47:06.198 --> 00:47:07.825
Good?
- Good job.

00:47:09.368 --> 00:47:11.203
Kind of lean forward
into your arms.

00:47:13.497 --> 00:47:16.458
- So at the same time?
- Yeah, try that once.

00:47:24.550 --> 00:47:27.261
It's okay, I'm still
right here with you.

00:47:27.261 --> 00:47:28.720
- Yes, yes.

00:47:28.720 --> 00:47:30.472
- Good, good.

00:47:32.266 --> 00:47:34.768
- When you think of Ryan,
what he used to be able to do

00:47:34.768 --> 00:47:39.439
and what um, what he can do now.

00:47:40.774 --> 00:47:43.861
It's tough, especially
for me being a dad

00:47:45.404 --> 00:47:48.198
that's use to seeing
him so big and strong

00:47:49.324 --> 00:47:51.910
but it's just tough, it's tough.

00:47:51.910 --> 00:47:53.579
(somber piano music)

00:47:53.579 --> 00:47:55.372
If we didn't have
these stem cells,

00:47:55.372 --> 00:47:57.583
I don't know how
much hope I'd have.

00:47:59.418 --> 00:48:01.587
- Can you scratch my eye?

00:48:03.463 --> 00:48:05.424
- Which one?
- This one.

00:48:05.424 --> 00:48:06.675
- Like under it?

00:48:06.675 --> 00:48:07.843
- This one!

00:48:07.843 --> 00:48:08.719
- Oh.

00:48:09.887 --> 00:48:11.430
- In the thoracic spinal cord,

00:48:11.430 --> 00:48:13.348
cells have to grow all the way

00:48:13.348 --> 00:48:15.183
from the middle of the chest,

00:48:15.183 --> 00:48:16.852
down to the bottom of the spine

00:48:16.852 --> 00:48:20.272
and make connections in order
to make those nerves work

00:48:20.272 --> 00:48:21.565
to go to the legs.

00:48:21.565 --> 00:48:23.317
That's a long distance.

00:48:23.317 --> 00:48:26.403
In the neck, every
one or two centimeters

00:48:26.403 --> 00:48:29.489
will return a function
in the upper extremities.

00:48:31.283 --> 00:48:32.951
So for example, the neck is,

00:48:32.951 --> 00:48:35.704
the vertebrae are called
cervical vertebrae

00:48:35.704 --> 00:48:38.457
and the fifth cervical
vertebrae has a nerve

00:48:38.457 --> 00:48:42.753
which allows you to shrug your
shoulders and lift your arms.

00:48:42.753 --> 00:48:46.506
The sixth allows you
to move your biceps.

00:48:46.506 --> 00:48:49.301
The seventh allows you
to move your triceps

00:48:49.301 --> 00:48:51.720
and gives you some
function in your hand.

00:48:51.720 --> 00:48:54.890
And the eighth gives you most
of the rest of the function

00:48:54.890 --> 00:48:57.434
in your hand, along
with the first thoracic.

00:48:57.434 --> 00:49:01.647
Those different levels are
only one centimeter apart.

00:49:01.647 --> 00:49:05.359
So if I can get these cells
to grow two centimeters,

00:49:05.359 --> 00:49:07.486
I can return one
level of function,

00:49:07.486 --> 00:49:09.404
maybe two levels of function

00:49:09.404 --> 00:49:12.366
because they're all located
very close to each other.

00:49:13.992 --> 00:49:16.662
The trial that we are doing
right now is being done

00:49:16.662 --> 00:49:20.707
by a team of a few very
dedicated neurosurgeons.

00:49:20.707 --> 00:49:22.542
We are seeing results

00:49:22.542 --> 00:49:25.837
that we have never
seen before in history.

00:49:25.837 --> 00:49:28.548
(upbeat music)

00:49:29.925 --> 00:49:32.970
- Well, I grew up
with my grandparents

00:49:32.970 --> 00:49:36.682
in a small town in
rural Wisconsin.

00:49:36.682 --> 00:49:40.852
So it's, you know, middle
of nowhere kind of place.

00:49:40.852 --> 00:49:44.731
And I'd rather be here
than in a big city.

00:49:53.281 --> 00:49:55.409
- We had two children

00:49:55.409 --> 00:49:57.703
and we have a
daughter and a son,

00:49:57.703 --> 00:49:59.871
and Lucas is our grandson.

00:50:01.707 --> 00:50:03.583
- There you go.

00:50:03.583 --> 00:50:06.670
- Lucas' father was killed
in an airplane accident.

00:50:06.670 --> 00:50:10.549
We're definitely mother and
father role all the way.

00:50:10.549 --> 00:50:12.467
Raised him since he's two.

00:50:12.467 --> 00:50:14.928
I've got tomato, pepper
and cukes as plants.

00:50:14.928 --> 00:50:17.931
And then seeds, I got
radishes and spinach.

00:50:17.931 --> 00:50:19.850
He just said watermelon,

00:50:19.850 --> 00:50:22.978
you can plant watermelon
on the ground in the back.

00:50:22.978 --> 00:50:24.563
- Yeah.
- You can do it.

00:50:24.563 --> 00:50:27.899
You spiral it, as it
grows up, you spiral it,

00:50:27.899 --> 00:50:30.986
you pin it down, the
plant just spirals.

00:50:31.862 --> 00:50:34.489
I saw a deer

00:50:35.449 --> 00:50:37.659
and tried to miss it

00:50:38.952 --> 00:50:42.748
and the front
passenger tire blew out

00:50:43.832 --> 00:50:46.668
and the truck started to roll.

00:50:46.668 --> 00:50:49.504
I was thrown out of the window

00:50:49.504 --> 00:50:51.506
as soon as it started to roll.

00:50:51.506 --> 00:50:54.051
So I landed on the pavement.

00:50:55.594 --> 00:50:58.096
- Luke was in a
coma for a few days.

00:50:58.096 --> 00:51:00.599
And I remember when he came out,

00:51:00.599 --> 00:51:04.644
he was stuck in a body
that couldn't move.

00:51:06.772 --> 00:51:08.982
Yeah, that was devastating.
- Yeah.

00:51:10.817 --> 00:51:15.530
- I woke up and I could
only like lift my head up

00:51:16.615 --> 00:51:18.658
a little bit, like a little bit.

00:51:18.658 --> 00:51:21.912
I thought it was pretty
much over at that point.

00:51:21.912 --> 00:51:24.498
The doctor's saying
I'll never feed myself,

00:51:24.498 --> 00:51:28.502
I'll never bathe myself, I'll
never put my contacts in,

00:51:28.502 --> 00:51:30.462
I'll never brush my teeth,

00:51:30.462 --> 00:51:32.964
I'll never do any of that
all on my own ever again.

00:51:34.091 --> 00:51:36.927
But during that time I was asked

00:51:36.927 --> 00:51:40.806
if I wanted to participate
in a stem cell study.

00:51:40.806 --> 00:51:43.809
and it was pretty
much a no-brainer.

00:51:43.809 --> 00:51:46.853
I mean, what's the
worst that can happen?

00:51:46.853 --> 00:51:48.897
Let's give it a try.

00:51:50.482 --> 00:51:54.152
(birds chirping)
(soft piano music)

00:51:54.152 --> 00:51:57.697
- It's not as hard to live
with HIV now as it was

00:51:57.697 --> 00:52:00.700
but it's expensive to treat.

00:52:00.700 --> 00:52:03.495
When I was first diagnosed,
my health insurance

00:52:03.495 --> 00:52:06.790
didn't cover the majority
of my medications.

00:52:06.790 --> 00:52:10.168
It was $1,500 a month out
of pocket that thank God,

00:52:10.168 --> 00:52:12.671
there's government
assistant programs

00:52:12.671 --> 00:52:14.923
that covered that for me.

00:52:14.923 --> 00:52:17.634
- In the United States, we
have about a little more

00:52:17.634 --> 00:52:19.845
than a million living with HIV,

00:52:19.845 --> 00:52:23.765
but there is about
50,000 new cases a year.

00:52:23.765 --> 00:52:26.518
We are in the process of a study

00:52:26.518 --> 00:52:29.104
in which we're going
to do autologous

00:52:29.104 --> 00:52:32.190
meaning their own stem
cells, that will be edited.

00:52:32.190 --> 00:52:34.526
The cells will lose their CCR5.

00:52:34.526 --> 00:52:36.194
We'll transplant them back in

00:52:36.194 --> 00:52:38.697
and we're gonna see if
it'll grow back cells

00:52:38.697 --> 00:52:40.448
that are CCR5 negative.

00:52:40.448 --> 00:52:42.200
So if the cell
doesn't have CCR5,

00:52:42.200 --> 00:52:44.119
the virus usually cannot get in.

00:52:44.119 --> 00:52:47.497
And it will allow
the control of HIV.

00:52:47.497 --> 00:52:50.709
- Stem cell therapies and gene
therapies are providing us

00:52:50.709 --> 00:52:54.629
with completely different ways
of thinking about medicine.

00:52:54.629 --> 00:52:58.884
Taking out somebody's
cells, fixing what is wrong

00:52:58.884 --> 00:53:01.219
and then putting the
cells back in the body

00:53:01.219 --> 00:53:04.639
and letting this much
more natural process occur

00:53:04.639 --> 00:53:06.558
and giving people the tools

00:53:06.558 --> 00:53:09.561
for the body to
fight these diseases.

00:53:11.479 --> 00:53:13.690
- Well, I don't know if
you can see this but,

00:53:13.690 --> 00:53:16.526
Amelie, you didn't go up
there with us but look,

00:53:16.526 --> 00:53:19.571
myself and Alessandro
after the run.

00:53:20.906 --> 00:53:22.741
So it's a couple
of pictures, but...

00:53:22.741 --> 00:53:25.076
- Yeah, hold on, hold on.
- Can you see that?

00:53:25.076 --> 00:53:27.579
- Yeah, but I see the
number right there.

00:53:27.579 --> 00:53:29.206
- So the first thing I noticed

00:53:29.206 --> 00:53:31.958
that immediately within
a month improved,

00:53:31.958 --> 00:53:34.753
which is, you know, a
month is immediate to me,

00:53:34.753 --> 00:53:36.713
it was making a grocery list.

00:53:36.713 --> 00:53:38.632
And I thought, oh, it's okay.

00:53:38.632 --> 00:53:42.260
I'll just make my list and
then have German read it.

00:53:42.260 --> 00:53:44.930
But as I was making the
list, I thought, oh,

00:53:44.930 --> 00:53:47.015
let me just see what I can see.

00:53:47.015 --> 00:53:50.268
And I looked at it and I was
able to read my own writing.

00:53:50.268 --> 00:53:54.064
And it was the first time I
could do that in 10 years.

00:53:56.775 --> 00:53:58.902
- Don't sit on my
book. (laughing)

00:53:58.902 --> 00:54:00.612
- Don't sit on what?
- Her book.

00:54:00.612 --> 00:54:02.030
- I think it was a miracle

00:54:02.030 --> 00:54:04.532
that you're gaining
your sight back.

00:54:04.532 --> 00:54:07.786
And it's a delicate
subject I think.

00:54:07.786 --> 00:54:12.624
- I know that stem cells
are from unborn fetuses

00:54:12.624 --> 00:54:15.627
- And not always, some of them.

00:54:15.627 --> 00:54:17.087
- Not always,

00:54:17.087 --> 00:54:19.089
but if somebody has
retinitis pigmentosa

00:54:19.089 --> 00:54:21.716
and they have the option
to have stem cells

00:54:21.716 --> 00:54:24.219
that come from an unborn baby,

00:54:25.303 --> 00:54:27.722
does that mean that it's wrong?

00:54:29.557 --> 00:54:31.810
- Do they take the life of the
baby for that specifically?

00:54:31.810 --> 00:54:33.561
Or like, if they're not alive

00:54:33.561 --> 00:54:36.815
then those could be
used to heal somebody.

00:54:36.815 --> 00:54:40.151
- So some people think
that they're being aborted

00:54:40.151 --> 00:54:42.862
for this purpose, but
that's not the case.

00:54:42.862 --> 00:54:47.158
I go back to saying abortion is,

00:54:47.158 --> 00:54:50.662
I can't tell someone
not to or to have one,

00:54:50.662 --> 00:54:52.789
that's a personal issue.

00:54:52.789 --> 00:54:57.168
And I think that
discarding the tissue is

00:54:57.168 --> 00:54:59.713
not what you should do

00:54:59.713 --> 00:55:02.215
because if they are going
to have an abortion,

00:55:02.215 --> 00:55:04.175
then please by all means,

00:55:04.175 --> 00:55:09.180
do something that can help
someone else with that tissue.

00:55:09.180 --> 00:55:11.933
I think that's the
important thing.

00:55:13.351 --> 00:55:15.228
- All of a sudden,

00:55:15.228 --> 00:55:19.816
my youngest son is diagnosed
with type one diabetes.

00:55:21.651 --> 00:55:26.364
You realize that this solid
life that was predictable

00:55:27.282 --> 00:55:29.242
is now unpredictable.

00:55:29.242 --> 00:55:32.370
And that every single day

00:55:32.370 --> 00:55:36.875
not only is my
son's life at risk

00:55:36.875 --> 00:55:40.628
but if he has too many
swings in his blood sugars,

00:55:40.628 --> 00:55:44.049
he may lose his
sight early in life.

00:55:44.049 --> 00:55:47.177
He may lose his kidneys.

00:55:48.636 --> 00:55:52.223
It's really a different world.

00:55:52.223 --> 00:55:55.268
- Embryonic stem cell
research may be the single

00:55:55.268 --> 00:55:59.314
most important
scientific discovery in
all of our lifetimes.

00:55:59.314 --> 00:56:02.734
The most renowned scientists
in the country have told us

00:56:02.734 --> 00:56:05.862
that this research holds forth
the promise of treatments

00:56:05.862 --> 00:56:08.907
and perhaps cures for some
of the most debilitating

00:56:08.907 --> 00:56:11.951
diseases affecting our
entire nation and the world.

00:56:11.951 --> 00:56:14.913
- For someone with
type one diabetes

00:56:14.913 --> 00:56:17.415
like many other
chronic diseases,

00:56:17.415 --> 00:56:21.086
whether it's cancer or
post major heart attack

00:56:21.086 --> 00:56:25.715
or a child born with
a genetic disease,

00:56:25.715 --> 00:56:30.678
you're running as fast as you
can, as carefully as you can.

00:56:32.055 --> 00:56:35.266
My son, Jordan, in the
middle of the night,

00:56:35.266 --> 00:56:40.271
four o'clock in the morning,
he'd wake up massive headaches,

00:56:41.856 --> 00:56:45.110
blood sugars at 400, he
hadn't eaten anything.

00:56:45.110 --> 00:56:50.031
You realize that this is
a precious opportunity.

00:56:50.031 --> 00:56:52.951
If we were going to
really cure this disease,

00:56:54.119 --> 00:56:57.247
we would need cell lines

00:56:57.247 --> 00:57:00.250
probably derived from
embryonic stem cells.

00:57:00.250 --> 00:57:04.087
These microscopic cells that
are otherwise thrown away

00:57:04.087 --> 00:57:07.757
from after in vitro
fertilization is
finished for a family.

00:57:07.757 --> 00:57:09.843
These were the very cell lines

00:57:09.843 --> 00:57:14.139
that the president had
blocked further development on

00:57:14.139 --> 00:57:17.976
besides the very isolated
group that already existed.

00:57:19.394 --> 00:57:21.312
- Hello dear.
- Hi.

00:57:21.312 --> 00:57:22.480
- How are you?

00:57:22.480 --> 00:57:24.482
I like your pretty dress today.

00:57:24.482 --> 00:57:25.984
Do you want some stickers?

00:57:25.984 --> 00:57:27.444
- Stickers.
- All right.

00:57:27.444 --> 00:57:28.820
- Want to show your dress?
- Yeah.

00:57:28.820 --> 00:57:30.488
- What princess are you today?

00:57:30.488 --> 00:57:31.489
- Rapunzel.

00:57:31.489 --> 00:57:34.200
Rapunzel, of course.

00:57:34.200 --> 00:57:36.453
How are you Erica?
- I'm doing good.

00:57:36.453 --> 00:57:38.872
Her immune system
wasn't doing so great.

00:57:38.872 --> 00:57:41.958
So they told us, you guys
need to come back out

00:57:41.958 --> 00:57:46.963
to San Francisco for
another transplant.

00:57:46.963 --> 00:57:50.925
And so, we grew up in a small
town, Tuba City, Arizona

00:57:50.925 --> 00:57:54.012
and it's located on
the Navajo Reservation.

00:57:54.012 --> 00:57:55.513
So my whole family,

00:57:55.513 --> 00:57:57.932
we're full Navajo
Native American.

00:57:57.932 --> 00:58:00.185
We're very deep
into our culture,

00:58:00.185 --> 00:58:03.354
our Navajo traditions,
cultural beliefs.

00:58:03.354 --> 00:58:06.483
We did a protection
prayer for her

00:58:06.483 --> 00:58:11.362
and we sat up all night,
prayed, sang songs,

00:58:11.362 --> 00:58:13.031
the drum beating.

00:58:13.031 --> 00:58:15.408
I could feel it,
just in the hogan.

00:58:15.408 --> 00:58:17.535
It was a miracle
and it did work.

00:58:17.535 --> 00:58:22.081
I feel it did work because
after that protection ceremony

00:58:22.081 --> 00:58:25.084
we left to San
Francisco a week later,

00:58:25.084 --> 00:58:29.881
Ava was supposed to
go through chemo again

00:58:29.881 --> 00:58:33.051
but a miracle happened

00:58:33.051 --> 00:58:35.553
and Dr. Dvorak called us.

00:58:35.553 --> 00:58:38.181
He said, "I have
some good news."

00:58:38.181 --> 00:58:40.850
He said, "There's a trial

00:58:40.850 --> 00:58:43.269
if you guys don't
want to do chemo."

00:58:43.269 --> 00:58:46.439
And then at that
moment, I noticed,

00:58:46.439 --> 00:58:49.526
God, we just prayed
about this last week,

00:58:49.526 --> 00:58:51.402
the protection ceremony.

00:58:51.402 --> 00:58:53.988
So right away, I
called my grandmother.

00:58:53.988 --> 00:58:56.032
I said, "The prayers worked."

00:58:56.032 --> 00:58:59.327
- The first patient,
I think on any trial

00:58:59.327 --> 00:59:01.371
is a very brave person.

00:59:01.371 --> 00:59:04.541
This is the pioneering
treatment that will bring us

00:59:04.541 --> 00:59:07.460
out of the era of chemotherapy.

00:59:07.460 --> 00:59:09.379
- Thank you.

00:59:09.379 --> 00:59:13.424
What Ava has is a very, very
difficult type of disease

00:59:13.424 --> 00:59:17.136
to transplant and so the
survival rates aren't as good

00:59:17.136 --> 00:59:20.515
and so we've always been
looking for better ways

00:59:20.515 --> 00:59:22.308
to do these transplants.

00:59:22.308 --> 00:59:24.435
- Ava didn't have
to go through chemo.

00:59:24.435 --> 00:59:26.854
She didn't have to lose her hair

00:59:26.854 --> 00:59:30.483
and all the side effects
that come with chemo, nausea,

00:59:30.483 --> 00:59:32.527
it could affect her eyesight,

00:59:32.527 --> 00:59:35.113
it could affect her
reproductive system.

00:59:35.113 --> 00:59:37.615
And we said, "Of course,
we want to do this.

00:59:37.615 --> 00:59:40.994
We've seen what chemo does
to her and her little body."

00:59:40.994 --> 00:59:44.205
And he said, "Ava will
be the first toddler ever

00:59:44.205 --> 00:59:47.417
to do this trial
with no toxicity."

00:59:47.417 --> 00:59:51.212
It's like, God has
answered our prayers.

00:59:52.297 --> 00:59:54.632
- Well, in our trial, the kids,

00:59:54.632 --> 00:59:57.385
they don't make a
normal immune response

00:59:57.385 --> 00:59:59.596
so they can't fight infections.

00:59:59.596 --> 01:00:03.391
And what we know we
can do is replace their

01:00:03.391 --> 01:00:06.394
blood forming
systems with a donors

01:00:06.394 --> 01:00:10.440
so that then the donor cells
can then make the white cells

01:00:10.440 --> 01:00:13.985
that can protect them from
getting the infections.

01:00:13.985 --> 01:00:17.113
The trial is to make bone marrow

01:00:17.113 --> 01:00:19.991
stem cell transplants safer.

01:00:19.991 --> 01:00:22.619
And the way that it's
done currently is

01:00:22.619 --> 01:00:26.122
that one uses
chemotherapy and radiation

01:00:26.122 --> 01:00:29.334
to eliminate the
recipient cells.

01:00:29.334 --> 01:00:31.544
And then the
purpose of the trial

01:00:31.544 --> 01:00:33.921
is to replace that chemotherapy

01:00:33.921 --> 01:00:36.633
and radiation with a
molecule that's safe.

01:00:36.633 --> 01:00:39.510
But what chemotherapy
is, is poison.

01:00:39.510 --> 01:00:42.347
I mean, poison that
damages their DNA,

01:00:42.347 --> 01:00:44.432
damages their chromosomes,

01:00:44.432 --> 01:00:46.643
and this therapy
could replace that

01:00:46.643 --> 01:00:51.022
because it's like a magic
bullet eliminating those cells.

01:00:51.022 --> 01:00:53.524
- Are you ready to go?
- Yeah!

01:00:59.530 --> 01:01:04.369
- So the first point is to
define stem cells for you.

01:01:04.369 --> 01:01:06.120
It's very easy.

01:01:06.120 --> 01:01:08.373
When a stem cell divides

01:01:08.373 --> 01:01:12.251
on average half of the daughter
cells are still stem cells,

01:01:12.251 --> 01:01:14.170
but you can make cell lines

01:01:14.170 --> 01:01:18.049
and you can get what's
called embryonic stem cells.

01:01:18.049 --> 01:01:21.260
And from them, try to
develop blood forming

01:01:21.260 --> 01:01:24.222
and brain forming stem
cells for co-transplant.

01:01:24.222 --> 01:01:26.557
President George
W. Bush comes out

01:01:26.557 --> 01:01:28.976
with his mainly
religious backers

01:01:28.976 --> 01:01:32.230
and says the federal
government will no longer fund

01:01:32.230 --> 01:01:35.191
the formation of new
embryonic stem cell lines,

01:01:35.191 --> 01:01:38.027
will not fund the
reprogramming at all.

01:01:38.027 --> 01:01:39.487
We ban that funding.

01:01:39.487 --> 01:01:41.572
We will fund research
from cell lines

01:01:41.572 --> 01:01:43.324
that had been made before.

01:01:43.324 --> 01:01:45.118
We knew they were imperfect,

01:01:45.118 --> 01:01:46.703
the ones that were made before.

01:01:46.703 --> 01:01:48.579
We know they didn't
include anybody

01:01:48.579 --> 01:01:50.248
who had a genetic disease

01:01:50.248 --> 01:01:53.126
that we wanted to
understand and treat.

01:01:53.126 --> 01:01:56.587
And that contributed to
the parents of diabetics

01:01:56.587 --> 01:02:00.425
and the children of
Alzheimer's patients saying,

01:02:00.425 --> 01:02:02.260
"Wait a second,

01:02:02.260 --> 01:02:05.012
does the federal government
really have the right

01:02:05.012 --> 01:02:08.141
to prevent the research
that could cure my family?"

01:02:08.141 --> 01:02:12.603
Proposition 71 dealt
with a pressing need

01:02:12.603 --> 01:02:15.106
that California
had the right to do

01:02:15.106 --> 01:02:17.775
because the federal
government wouldn't do it.

01:02:17.775 --> 01:02:22.780
The stakes here are curing a
large, large number of diseases

01:02:24.282 --> 01:02:27.660
through this opening
of stem cells.

01:02:27.660 --> 01:02:32.290
We can change the whole
balance of our economy

01:02:32.290 --> 01:02:35.793
and for people to live longer
and more productive lives

01:02:35.793 --> 01:02:38.629
if we can make it
work for everybody.

01:02:38.629 --> 01:02:40.298
Here you are at Stanford,

01:02:40.298 --> 01:02:43.050
a place where
discoveries take place,

01:02:43.050 --> 01:02:46.471
thanks to the
California Institute of
Regenerative Medicine

01:02:46.471 --> 01:02:49.640
that allows us to
do clinical trials.

01:02:49.640 --> 01:02:51.684
Thank you.
(audience applauding)

01:02:51.684 --> 01:02:55.480
If you want biomedical
research to go forward,

01:02:55.480 --> 01:02:57.607
this is unique to California.

01:02:57.607 --> 01:03:00.234
And because we asked
the California people,

01:03:00.234 --> 01:03:03.780
not the California legislature
or the California governor,

01:03:03.780 --> 01:03:06.532
it happened, 59 to 41.

01:03:06.532 --> 01:03:10.661
That's why I say this
is a medical revolution.

01:03:19.337 --> 01:03:21.172
- What, up?
- I'm so excited.

01:03:21.172 --> 01:03:22.256
I'm so nervous.

01:03:24.467 --> 01:03:26.427
- Here he is. Here he is.

01:03:26.427 --> 01:03:28.179
- Oh!
- Where?

01:03:28.179 --> 01:03:30.681
- Oh, I see him.
- Where? I don't see him!

01:03:30.681 --> 01:03:32.767
Where is he? I can't see him.

01:03:34.352 --> 01:03:36.521
- He's on his power wheelchair.

01:03:36.521 --> 01:03:38.231
- I see him.

01:03:41.776 --> 01:03:43.152
Hey Ry!

01:03:43.152 --> 01:03:44.695
- Yeah!

01:03:44.695 --> 01:03:47.865
(crowd clapping and cheering)

01:03:52.286 --> 01:03:54.539
- What's up, buddy?
Welcome home.

01:03:54.539 --> 01:03:57.708
- It's so good to see you.

01:04:02.547 --> 01:04:04.423
It's a happy time.

01:04:05.633 --> 01:04:07.552
- Welcome home, buddy.

01:04:08.803 --> 01:04:10.721
- Ryan, I'm so happy!

01:04:12.223 --> 01:04:15.142
- Coming home after
around five months was,

01:04:16.561 --> 01:04:18.771
it was incredible seeing
everybody at the airport

01:04:18.771 --> 01:04:20.815
I knew they were gonna be there,

01:04:20.815 --> 01:04:23.860
but I didn't know they were
gonna have all those signs

01:04:23.860 --> 01:04:26.529
and like clapping and just
happy for me coming home

01:04:26.529 --> 01:04:28.197
so that really felt good.

01:04:28.197 --> 01:04:30.616
- Ready to go home? Let's go.

01:04:41.168 --> 01:04:42.920
- Welcome to your crib, Ry.

01:04:44.463 --> 01:04:46.507
Dude, it's so sweet.
I'm not kidding.

01:04:49.468 --> 01:04:51.262
- Wow.

01:04:51.262 --> 01:04:53.264
This is really nice.

01:04:54.640 --> 01:04:56.517
- I think I'm at
a strangers house.

01:04:56.517 --> 01:04:58.811
- I wanted to see
Ryan, where is he?

01:04:58.811 --> 01:05:00.313
What ya think, Ry?

01:05:00.313 --> 01:05:01.606
- Yeah, it's cool.

01:05:01.606 --> 01:05:03.357
- Like it?
- A little small but,

01:05:03.357 --> 01:05:04.775
- A little small?

01:05:04.775 --> 01:05:07.695
We can knock out a
wall or two for you.

01:05:10.281 --> 01:05:14.535
- Me and Ryan started
hanging out as sophomores

01:05:14.535 --> 01:05:16.913
going to be juniors
in high school.

01:05:16.913 --> 01:05:19.957
That's when we started to
like each other I guess

01:05:19.957 --> 01:05:21.792
and Ryan is a great person.

01:05:21.792 --> 01:05:23.628
He is hysterical.

01:05:23.628 --> 01:05:26.422
I mean, he can make
anybody laugh at any time.

01:05:26.422 --> 01:05:28.966
You can ask anybody,
they would just tell you

01:05:28.966 --> 01:05:32.553
he was just the guy in the
room that was making you laugh

01:05:32.553 --> 01:05:34.722
or saying something
stupid or funny.

01:05:34.722 --> 01:05:37.767
That's just always how he was.

01:05:37.767 --> 01:05:40.603
Alrighty. I'm leaving.

01:05:40.603 --> 01:05:43.356
I'll see you Saturday.

01:05:43.356 --> 01:05:45.483
- All right.

01:05:45.483 --> 01:05:47.985
- I'm gonna get my shoes.

01:05:47.985 --> 01:05:49.737
Bye.
- See ya, thanks.

01:05:49.737 --> 01:05:51.489
- You're welcome.

01:05:51.489 --> 01:05:53.574
- Love you.
- Love you too.

01:05:53.574 --> 01:05:55.701
- See ya, Alyssa.
- See ya.

01:05:57.995 --> 01:05:59.914
- Ryan, is this good?

01:05:59.914 --> 01:06:01.832
Ryan is finally home and
it's been a busy few days

01:06:01.832 --> 01:06:04.001
at the Custer house
getting adjusted.

01:06:04.001 --> 01:06:05.670
Shh, listen.

01:06:05.670 --> 01:06:07.338
And we just wanna
remind everyone

01:06:07.338 --> 01:06:08.923
of the prayer service
happening this Sunday

01:06:08.923 --> 01:06:10.257
at 2:30 at Elder's Fieldhouse.

01:06:10.257 --> 01:06:11.926
Everyone's welcome to attend,

01:06:11.926 --> 01:06:13.678
please come and give Ryan
the warm welcome he deserves.

01:06:13.678 --> 01:06:15.554
- The warm welcome he deserves?

01:06:15.554 --> 01:06:17.682
What, did I just
save the country?

01:06:17.682 --> 01:06:19.517
- Coming back from Iraq.

01:06:19.517 --> 01:06:21.852
Let's just say,
everybody please come out

01:06:21.852 --> 01:06:23.729
and give Ryan a warm welcome.

01:06:23.729 --> 01:06:26.565
- But Dad gave me the second
concussion of the past month.

01:06:26.565 --> 01:06:28.359
- I thought we weren't going
to say anything about that

01:06:28.359 --> 01:06:29.819
in front of your mother.

01:06:29.819 --> 01:06:31.862
- She doesn't know
what's happening.

01:06:31.862 --> 01:06:33.030
- What?

01:06:33.030 --> 01:06:34.699
- He didn't get a concussion.

01:06:34.699 --> 01:06:36.701
- He almost got
into a car accident.

01:06:36.701 --> 01:06:38.536
- It wasn't, no.

01:06:38.536 --> 01:06:40.496
- I was in a car accident
with the dashboard.

01:06:40.496 --> 01:06:42.373
(laughing)

01:06:42.373 --> 01:06:44.709
- We were looking for buffalo
and we couldn't find them.

01:06:44.709 --> 01:06:46.419
- So I'll tell you,

01:06:46.419 --> 01:06:48.045
we're going down a hill

01:06:48.045 --> 01:06:50.381
and there's people
like halfway down.

01:06:50.381 --> 01:06:52.550
So Dad's like, "Oh,
let's stop and ask 'em."

01:06:52.550 --> 01:06:55.720
Well, he steps on the brakes
and forgot I didn't have abs

01:06:55.720 --> 01:06:57.430
so I can't hold myself up.

01:06:57.430 --> 01:06:59.557
And I go and I
drill the dashboard.

01:06:59.557 --> 01:07:02.476
And the people are like,
"Uh, you all right in there?"

01:07:02.476 --> 01:07:04.353
- Oh my God, he's paralyzed.

01:07:04.353 --> 01:07:06.772
He has no control over his body.

01:07:06.772 --> 01:07:10.484
I don't understand how he can
keep such a positive attitude.

01:07:10.484 --> 01:07:14.739
But for whatever reason,
something within him,

01:07:14.739 --> 01:07:17.742
the strength that
he has emotionally

01:07:17.742 --> 01:07:20.077
is just unbelievable.

01:07:24.790 --> 01:07:27.418
- Danielle, can you
feed me for a dollar?

01:07:27.418 --> 01:07:29.712
- I'll feed you for free, babe.

01:07:29.712 --> 01:07:32.048
- He'll blow your crap.

01:07:33.591 --> 01:07:35.801
And that's another
side of him too

01:07:35.801 --> 01:07:37.553
that he has never lost.

01:07:37.553 --> 01:07:40.389
And I've got like a 25
minute speech prepared.

01:07:40.389 --> 01:07:42.475
- I got about a
two minute speech.

01:07:42.475 --> 01:07:44.685
- I won't get through
any of it, trust me.

01:07:44.685 --> 01:07:46.645
Every time I read
it, I start balling.

01:07:46.645 --> 01:07:48.522
- You already have your speech?

01:07:48.522 --> 01:07:49.774
- I got in my pocket.

01:07:49.774 --> 01:07:51.400
- What the hell?

01:07:51.400 --> 01:07:52.860
- What, do you think
I'm going to wing it?

01:07:52.860 --> 01:07:54.737
- I am.

01:07:54.737 --> 01:07:55.863
- You're gonna wing it
in front of 4,000 people?

01:07:55.863 --> 01:07:57.740
- I don't break under pressure.

01:07:57.740 --> 01:07:59.867
- Well, Ry, you should write
something down at least.

01:07:59.867 --> 01:08:02.787
'Cause when you get in
front of all those people,

01:08:02.787 --> 01:08:04.830
you'll forget, you'll forget me.

01:08:04.830 --> 01:08:06.791
- Dad, you literally-
- I'm joking.

01:08:06.791 --> 01:08:09.794
- Most recently rammed him
into a dashboard of a car

01:08:09.794 --> 01:08:12.004
so I would really not bring up--

01:08:12.004 --> 01:08:13.839
- I blame GM, I blame GM.

01:08:13.839 --> 01:08:16.509
- I don't remember
anything honestly.

01:08:16.509 --> 01:08:18.844
- Oh, what a--
Kim, it wasn't bad.

01:08:18.844 --> 01:08:20.805
- Mom, you should
have been there.

01:08:20.805 --> 01:08:23.390
- I mean, he kind of hit
and bounced right back up

01:08:23.390 --> 01:08:24.558
so he was fine.

01:08:47.748 --> 01:08:51.168
- I think it's
scary when every day

01:08:51.168 --> 01:08:53.170
that you have this disease,

01:08:53.170 --> 01:08:55.506
you lose more and
more of your sight.

01:08:57.758 --> 01:09:01.178
There was this fear of someday,

01:09:01.178 --> 01:09:03.180
there would be no vision.

01:09:03.180 --> 01:09:05.432
Someday there wouldn't be that,

01:09:05.432 --> 01:09:07.143
not even that glimmer of light

01:09:07.143 --> 01:09:09.186
that I could still
see or shadows,

01:09:09.186 --> 01:09:12.523
and it was just the fear
of not having anything.

01:09:15.025 --> 01:09:17.111
- Blink, blink a couple times.

01:09:18.696 --> 01:09:21.031
So one single letter
here in the middle

01:09:21.031 --> 01:09:23.200
with some lines
around the edges.

01:09:24.743 --> 01:09:26.954
- I don't see
anything. (laughing)

01:09:26.954 --> 01:09:28.080
- Okay.

01:09:28.080 --> 01:09:30.040
- They punctured my eyeball

01:09:30.040 --> 01:09:32.585
and put the stem cells
right into the retina

01:09:32.585 --> 01:09:34.837
and afterward I felt fine.

01:09:34.837 --> 01:09:37.006
I felt great. I was excited.

01:09:37.006 --> 01:09:38.674
But after that I said,

01:09:38.674 --> 01:09:40.885
I would have done
it a hundred times

01:09:40.885 --> 01:09:42.887
if I had to do the
shots all the time.

01:09:42.887 --> 01:09:44.221
I would have done it.

01:09:44.221 --> 01:09:45.764
- What about this letter here?

01:09:45.764 --> 01:09:48.058
- Nice and bold but um...

01:09:48.058 --> 01:09:50.644
it's gonna be a wild guess.

01:09:50.644 --> 01:09:53.731
Seriously, gee
wiz, I don't know.

01:09:55.232 --> 01:09:56.609
I don't know.

01:09:58.235 --> 01:10:00.946
- Okay, yeah, try to kind of
shift the eyeball a little bit.

01:10:00.946 --> 01:10:03.741
Try to find the sweet
spot, there you go.

01:10:03.741 --> 01:10:05.910
- Just to be able
to improve my vision

01:10:05.910 --> 01:10:08.579
to make me just that
much more independent.

01:10:08.579 --> 01:10:10.706
Right now I'm very dependent.

01:10:10.706 --> 01:10:13.751
I would love to be
able to help my kids

01:10:13.751 --> 01:10:15.836
instead of my kids helping me.

01:10:15.836 --> 01:10:18.756
Wow, it's so fuzzy. Wow.

01:10:20.758 --> 01:10:24.178
I think this is the worst
I've ever done on this test.

01:10:24.178 --> 01:10:26.555
The screen looks
quite blank to me.

01:10:26.555 --> 01:10:27.765
- Right.
- Wow.

01:10:27.765 --> 01:10:30.100
- Jeff, you know what I noticed?

01:10:30.100 --> 01:10:31.936
- That's scary.
- Well we'll know now,

01:10:31.936 --> 01:10:36.023
when you start looking
through your treated eye.

01:10:37.107 --> 01:10:38.984
- We are ready to start again.

01:10:38.984 --> 01:10:40.903
Now we've got the left eye.

01:10:40.903 --> 01:10:42.279
What's that one look like?

01:10:42.279 --> 01:10:43.906
- It looks like a K.

01:10:43.906 --> 01:10:45.658
- All right. Very
good. Excellent.

01:10:45.658 --> 01:10:46.825
And this one.

01:10:46.825 --> 01:10:49.078
- That one is a V.

01:10:49.078 --> 01:10:51.538
- Yes. Correct. Very good.

01:10:51.538 --> 01:10:55.209
- I've thought about what
if the stem cell injection

01:10:55.209 --> 01:10:57.962
just the cells dissipate

01:10:57.962 --> 01:11:01.799
and it only improves a tiny bit.

01:11:01.799 --> 01:11:03.133
Is it O?

01:11:03.133 --> 01:11:05.970
- Okay. Very good. Excellent.

01:11:05.970 --> 01:11:07.888
- Or a D, could have been a D.

01:11:07.888 --> 01:11:10.724
But in my heart I really
feel like it's going to work.

01:11:10.724 --> 01:11:12.643
And that it's working.

01:11:13.936 --> 01:11:15.938
- Okay. We'll try another one.
- Okay.

01:11:17.022 --> 01:11:18.983
- And this one.
- The weird S.

01:11:18.983 --> 01:11:20.901
- Yes. Correct.
(Rosie laughing)

01:11:20.901 --> 01:11:22.861
I'm gonna bring the lights up.

01:11:24.238 --> 01:11:25.906
Okay. Sorry.

01:11:25.906 --> 01:11:27.283
Kind of bright in
here for you now.

01:11:27.283 --> 01:11:29.118
The right eye was 20/400

01:11:29.118 --> 01:11:31.328
and the left eye
was about 20/250.

01:11:31.328 --> 01:11:34.039
- Hey, that's an improvement.
- So that's fantastic.

01:11:34.039 --> 01:11:37.334
- 20/250, man.
- There you go, that's right.

01:11:38.335 --> 01:11:40.796
- Watch, duck.

01:11:40.796 --> 01:11:43.757
Yeah, that's it. There
was a branch right there.

01:11:43.757 --> 01:11:46.135
- Obviously a treatment of ours

01:11:46.135 --> 01:11:48.345
where we're trying
to preserve vision

01:11:48.345 --> 01:11:51.807
should in theory
have greatest impact

01:11:51.807 --> 01:11:53.934
before that vision is lost.

01:11:53.934 --> 01:11:56.353
So if we could go into people

01:11:56.353 --> 01:11:58.981
before the retina's degenerated

01:11:58.981 --> 01:12:02.693
we might have a bigger impact
on the course of their disease

01:12:02.693 --> 01:12:05.321
than we do after it's
already mostly gone.

01:12:05.321 --> 01:12:07.865
- Honey, there's like at
least a dozen bee right there.

01:12:07.865 --> 01:12:09.867
- Okay, don't disturb it.

01:12:09.867 --> 01:12:14.663
- Any kind of improvement in
central nervous system disease,

01:12:14.663 --> 01:12:17.374
I want to make the point
that that's a big deal.

01:12:17.374 --> 01:12:19.376
For all of human history.

01:12:19.376 --> 01:12:21.712
there's been nothing
you could do.

01:12:21.712 --> 01:12:24.089
- We're gonna throw
first over to that side.

01:12:24.089 --> 01:12:25.758
- Mm-hmm.

01:12:25.758 --> 01:12:27.718
- The first trials, you
have to enroll patients

01:12:27.718 --> 01:12:31.388
who are at the end stages
of the disease progression.

01:12:31.388 --> 01:12:34.683
Our initial patients
couldn't even count fingers

01:12:34.683 --> 01:12:37.061
if you put them right
in front of their face,

01:12:37.061 --> 01:12:38.896
but after treatment,

01:12:38.896 --> 01:12:43.067
they were able to navigate
in rooms on their own.

01:12:43.067 --> 01:12:45.903
Now that doesn't mean
reading the paper,

01:12:45.903 --> 01:12:48.155
doesn't mean watching TV,

01:12:48.155 --> 01:12:50.866
but it means they
could find the door.

01:12:50.866 --> 01:12:53.243
They could avoid
tripping over the chair.

01:12:53.243 --> 01:12:55.245
They could get around.

01:12:55.245 --> 01:12:57.748
In terms of daily living,

01:12:59.083 --> 01:13:01.752
I already feel like
it's a success.

01:13:01.752 --> 01:13:04.254
You know, these
people were blind.

01:13:04.254 --> 01:13:05.964
They had no hope.

01:13:05.964 --> 01:13:07.925
And now they have hope.

01:13:07.925 --> 01:13:09.927
I mean, something's changing.

01:13:09.927 --> 01:13:12.346
If you think about it
for all of human history

01:13:12.346 --> 01:13:15.432
this all only went one way
and that was down the tubes.

01:13:15.432 --> 01:13:18.936
And now somebody's starting
to get something back.

01:13:18.936 --> 01:13:21.271
It's modest but the
fact that this is

01:13:21.271 --> 01:13:23.440
going in reverse at all,

01:13:23.440 --> 01:13:25.109
to me,

01:13:27.194 --> 01:13:28.445
we're there.

01:13:30.447 --> 01:13:32.449
- Ooh, ooh.

01:13:32.449 --> 01:13:34.701
(family yelling)

01:13:34.701 --> 01:13:36.787
I don't believe it!

01:13:36.787 --> 01:13:38.455
Did you see that?

01:13:38.455 --> 01:13:40.290
She hit the ball!

01:13:44.002 --> 01:13:46.380
- I think just moving
my arms came first.

01:13:46.380 --> 01:13:49.174
Being able to just kind
of move those around.

01:13:49.174 --> 01:13:52.177
Not much, but just
something little.

01:13:52.177 --> 01:13:54.888
- So where do you
put these again?

01:13:54.888 --> 01:13:56.974
- My wrist.
- Right here?

01:13:56.974 --> 01:13:58.100
- Yeah.

01:13:58.100 --> 01:13:59.726
- Okay, let me put this on you

01:13:59.726 --> 01:14:01.979
and you can tell me
how long you want.

01:14:01.979 --> 01:14:04.356
Try that before I cut it off.

01:14:04.356 --> 01:14:05.899
- Yeah, it's good.

01:14:09.445 --> 01:14:11.989
But I could tell
every day my arms

01:14:11.989 --> 01:14:14.116
are getting just a
little bit stronger.

01:14:14.116 --> 01:14:16.160
I'm getting my wrist
now a little bit.

01:14:16.160 --> 01:14:18.996
I got that when I
was in Colorado.

01:14:18.996 --> 01:14:22.833
I've seen a little bit of finger
movement on both my hands,

01:14:22.833 --> 01:14:25.169
but it's kinda, those
muscles are so weak

01:14:25.169 --> 01:14:28.213
that one day they'll
move, one day they won't.

01:14:28.213 --> 01:14:30.048
Having your hands is,

01:14:30.048 --> 01:14:32.342
you kind of take it for granted
when you don't have them.

01:14:32.342 --> 01:14:36.180
Just like the littlest things
like scratching your nose,

01:14:36.180 --> 01:14:40.017
scratching your head,
picking your nose, anything.

01:14:40.017 --> 01:14:43.020
- 20 years ago,
doing our first study

01:14:43.020 --> 01:14:47.024
was a very interesting and
eye-opening experience.

01:14:47.024 --> 01:14:50.152
Nothing like this
had been done before.

01:14:50.152 --> 01:14:53.530
20 years ago, I had death
threats because of this study.

01:14:53.530 --> 01:14:56.533
At that time,
shortly before that,

01:14:56.533 --> 01:15:01.330
a physician who
performed abortions in
Florida was murdered.

01:15:01.330 --> 01:15:03.415
But then I got a letter saying,

01:15:03.415 --> 01:15:06.376
"If you do this study,
we will kill you."

01:15:06.376 --> 01:15:09.338
Well, the first thing, when
you open a letter like this

01:15:09.338 --> 01:15:11.215
is you don't believe it.

01:15:11.215 --> 01:15:13.842
You look at it and you think
this has gotta be a hoax.

01:15:13.842 --> 01:15:16.261
But then you realize
it might not be

01:15:16.261 --> 01:15:18.514
so we went to the police with it

01:15:18.514 --> 01:15:22.559
and they actually put
a guard around my house

01:15:22.559 --> 01:15:24.978
and escorted us back and forth.

01:15:24.978 --> 01:15:26.563
The day we did the surgery,

01:15:26.563 --> 01:15:30.067
the entire operating
room was on lock down.

01:15:30.067 --> 01:15:34.363
On the one hand, doing
research of this nature,

01:15:34.363 --> 01:15:38.116
which is on the edge so it's
reasonable to discuss that.

01:15:38.116 --> 01:15:39.576
On the other hand,

01:15:39.576 --> 01:15:42.955
it's unethical to deny a
patient who's paralyzed

01:15:42.955 --> 01:15:44.915
the possibility of being able

01:15:44.915 --> 01:15:47.584
to use his arms and legs again.

01:15:47.584 --> 01:15:49.836
(audience applauding)

01:15:49.836 --> 01:15:52.923
(audience cheering)

01:15:59.388 --> 01:16:02.182
- First, thanks to all of
you for coming out today

01:16:02.182 --> 01:16:05.060
and to help welcome Ryan home.

01:16:05.060 --> 01:16:07.437
The Ryan you see here today,

01:16:07.437 --> 01:16:09.856
(soft piano music)

01:16:12.067 --> 01:16:14.194
(Starting to cry)

01:16:14.194 --> 01:16:17.072
is by far not the final version.

01:16:17.072 --> 01:16:19.866
Although progress is
very slow and unknown,

01:16:19.866 --> 01:16:22.452
we pray and have hope
that he will continue

01:16:22.452 --> 01:16:25.330
to get more and more
back to get stronger.

01:16:25.330 --> 01:16:26.957
Only time will tell

01:16:26.957 --> 01:16:29.293
how much Ryan will
ultimately get back.

01:16:29.293 --> 01:16:32.045
But many other people
who have gotten

01:16:32.045 --> 01:16:35.257
the stem cell injections have
had wonderful improvement

01:16:35.257 --> 01:16:36.925
even after a year or so.

01:16:38.468 --> 01:16:40.887
I will tell you who
my personal hero is.

01:16:40.887 --> 01:16:42.931
(crying again)

01:16:42.931 --> 01:16:45.559
It's Ryan Custer.

01:16:45.559 --> 01:16:49.229
Each and every day, he wakes
up with a warriors mentality

01:16:50.522 --> 01:16:53.066
and faces his situation he is in

01:16:53.066 --> 01:16:56.153
with such a positive
attitude and work ethic.

01:16:57.571 --> 01:16:59.573
If you did not know
Ryan was paralyzed,

01:16:59.573 --> 01:17:02.159
by talking to him
you would never know

01:17:02.159 --> 01:17:04.411
he was any different
than he ever was.

01:17:04.411 --> 01:17:06.997
(audience applauding)

01:17:10.000 --> 01:17:12.002
- I didn't have
a speech prepared

01:17:12.002 --> 01:17:14.463
because I honestly
didn't know what to say.

01:17:14.463 --> 01:17:16.131
(audience laughing)

01:17:16.131 --> 01:17:18.550
But I just want to thank
you all for coming out.

01:17:18.550 --> 01:17:21.553
No one had to do this,
no one had to come here.

01:17:23.639 --> 01:17:25.641
As a 19 year old kid,

01:17:25.641 --> 01:17:28.143
you never really
realize this can happen.

01:17:28.143 --> 01:17:30.020
You never think about it.

01:17:30.020 --> 01:17:33.190
You always think it's gonna
happen to someone else but...

01:17:37.069 --> 01:17:39.029
So all the support I've gotten

01:17:39.029 --> 01:17:43.033
over the past five or so months
has been just incredible.

01:17:43.033 --> 01:17:45.619
I just can't thank
you guys enough.

01:17:45.619 --> 01:17:48.580
And obviously I'd like to
single out everybody in here

01:17:48.580 --> 01:17:51.500
that's helped me, but I'll
probably forget somebody

01:17:51.500 --> 01:17:53.543
or I don't want to
piss anybody off.

01:17:53.543 --> 01:17:55.379
(audience laughing)

01:17:55.379 --> 01:17:58.173
But there are a few
people I'd like to thank.

01:17:58.173 --> 01:18:00.175
McKenzie, Nick and Danielle.

01:18:00.175 --> 01:18:02.219
(crying)

01:18:07.224 --> 01:18:10.394
They've been there
every second of the way.

01:18:10.394 --> 01:18:13.230
Not even just being
there in person,

01:18:13.230 --> 01:18:15.732
but calling me, texting me,

01:18:15.732 --> 01:18:18.610
just letting me know
everything's going to be okay.

01:18:18.610 --> 01:18:20.737
I just can't thank
you guys enough.

01:18:21.738 --> 01:18:23.281
I love you too.

01:18:23.281 --> 01:18:27.119
(audience applauding
and cheering)

01:18:46.596 --> 01:18:48.682
- Okay. Eeek.

01:18:48.682 --> 01:18:52.102
Okay, do you want me to
Neosporin the stitches?

01:18:52.102 --> 01:18:53.520
- No.
- Okay.

01:18:53.520 --> 01:18:55.689
- Hey, Mom, Dad,
come down and play.

01:18:55.689 --> 01:18:59.443
You know, honey, in
a few hours, honey.

01:18:59.443 --> 01:19:01.611
I gotta barf.

01:19:08.410 --> 01:19:10.328
- Ugh.

01:19:16.585 --> 01:19:18.754
- Hello, hello. How's it?
- Hi.

01:19:18.754 --> 01:19:22.632
- How are you feeling?
- Hi, nice to see you.

01:19:22.632 --> 01:19:24.801
- The MRI, I'm gonna
show it to you,

01:19:24.801 --> 01:19:27.679
shows that these tumors
are bigger, okay?

01:19:27.679 --> 01:19:32.309
Which happens with the
treatment of the inflammation

01:19:32.309 --> 01:19:35.228
so I wouldn't say you've
had a response yet.

01:19:36.480 --> 01:19:38.064
Couple of options.

01:19:38.064 --> 01:19:40.150
We could start
another treatment,

01:19:40.150 --> 01:19:42.068
but I think we should continue

01:19:42.068 --> 01:19:44.237
giving you the next injections.

01:19:44.237 --> 01:19:46.072
If we give you more injections,

01:19:46.072 --> 01:19:48.158
it's possible that
may work better.

01:19:48.158 --> 01:19:49.576
- Okay.

01:19:49.576 --> 01:19:51.328
- So we've seen that
in other patients

01:19:51.328 --> 01:19:54.080
where initially the MRIs
were not conclusive.

01:19:54.080 --> 01:19:55.749
So based on the images,

01:19:55.749 --> 01:19:58.668
we have to say that the
tumor is progressing.

01:19:59.711 --> 01:20:02.088
Let me show you the scans again.

01:20:02.088 --> 01:20:03.507
- Ugh.

01:20:03.507 --> 01:20:05.592
- This is before we
started treatment.

01:20:05.592 --> 01:20:07.385
This is now, okay?

01:20:07.385 --> 01:20:09.429
You can tell this is bigger.
- Yeah.

01:20:10.847 --> 01:20:13.850
- Depending on how you,
this side is bigger.

01:20:20.440 --> 01:20:21.483
This is

01:20:22.776 --> 01:20:25.570
stable.
- Okay.

01:20:25.570 --> 01:20:27.489
That thing grows fast, huh?

01:20:27.489 --> 01:20:29.282
- Yeah. I've seen this before,

01:20:29.282 --> 01:20:31.535
some areas respond
better than others,

01:20:31.535 --> 01:20:33.161
but I think, for example,

01:20:33.161 --> 01:20:34.746
that is a bit smaller than that.

01:20:34.746 --> 01:20:35.872
- Right.

01:20:35.872 --> 01:20:37.666
- If we look at this data,

01:20:37.666 --> 01:20:41.127
this is the fluid that
we got from the tapping.

01:20:41.127 --> 01:20:42.504
- Uh-huh, uh-huh.

01:20:42.504 --> 01:20:44.381
- So the first injection we did,

01:20:44.381 --> 01:20:46.508
if you look at the
white blood cells,

01:20:46.508 --> 01:20:48.385
this is after the
first injections.

01:20:48.385 --> 01:20:50.220
Only six white blood cells.

01:20:50.220 --> 01:20:53.223
And these are the
ones that fight, okay?

01:20:53.223 --> 01:20:55.433
So that was the first one, okay?

01:20:55.433 --> 01:20:57.561
Now, the second time.

01:20:59.145 --> 01:21:00.897
We're up to 120.
- Oh, that's good.

01:21:00.897 --> 01:21:02.607
That's really good.

01:21:02.607 --> 01:21:05.235
Uh-huh, that's a
huge jump, okay.

01:21:06.278 --> 01:21:09.239
- The third time was here.

01:21:11.283 --> 01:21:13.368
318.
- Yay, oh that's good.

01:21:13.368 --> 01:21:15.328
That's really good. Okay.

01:21:15.328 --> 01:21:16.872
- So I think this is good.

01:21:16.872 --> 01:21:19.207
So in fact, it only
happened twice,

01:21:19.207 --> 01:21:20.876
but if you do six

01:21:20.876 --> 01:21:23.169
I think they're gonna get
it up, really high up.

01:21:23.169 --> 01:21:25.171
- That's great.
That's a good sign.

01:21:25.171 --> 01:21:26.923
Well I'm glad we ended on that.

01:21:26.923 --> 01:21:27.924
(laughing)

01:21:27.924 --> 01:21:29.759
Geeze. Oh God.

01:21:29.759 --> 01:21:30.927
Whew.

01:21:31.928 --> 01:21:33.430
- Yeah.

01:21:34.931 --> 01:21:36.600
- All right?

01:21:38.226 --> 01:21:41.646
- Thank you, very much.
- Thank you, all right.

01:21:48.278 --> 01:21:51.656
(Steve mumbling)

01:21:51.656 --> 01:21:53.909
- You're upset right now.

01:21:53.909 --> 01:21:55.660
(somber music)

01:22:06.296 --> 01:22:09.257
(Both crying softly)

01:22:20.518 --> 01:22:23.647
- This sucks.
- Yeah, it totally sucks.

01:22:26.942 --> 01:22:28.944
[Kelly] I love you.
- I love you.

01:22:30.487 --> 01:22:33.323
(touching soft music)

01:23:09.025 --> 01:23:11.861
- I have no idea where
I'm even gonna put these.

01:23:11.861 --> 01:23:14.698
- Weren't you gonna
put them at home?

01:23:14.698 --> 01:23:15.824
- Yeah.

01:23:15.824 --> 01:23:17.450
- Take them to the office.

01:23:17.450 --> 01:23:19.035
Maybe somebody else
would want 'em.

01:23:19.035 --> 01:23:20.704
- That's true.

01:23:20.704 --> 01:23:23.707
- It will be a first
in human experience

01:23:23.707 --> 01:23:26.710
that will have I think epic
proportions if it works,

01:23:26.710 --> 01:23:29.421
because then you
know you can do this

01:23:29.421 --> 01:23:32.298
for anything else as
well, not just HIV.

01:23:32.298 --> 01:23:34.300
The next step though is really

01:23:34.300 --> 01:23:36.761
can you stop their
anti-HIV pills

01:23:36.761 --> 01:23:40.473
and have those cells
be functional and
protect against HIV?

01:23:40.473 --> 01:23:42.559
So the real goal of
this will be to see

01:23:42.559 --> 01:23:44.894
whether we actually
take the patient off

01:23:44.894 --> 01:23:47.063
and in order to take
them off their pills,

01:23:47.063 --> 01:23:48.982
they have to have enough cells

01:23:48.982 --> 01:23:51.901
in their peripheral blood
that are genetically modified.

01:23:51.901 --> 01:23:54.612
- I realized I did not
take my pills last night.

01:23:54.612 --> 01:23:56.531
- Are you kidding me?

01:23:57.657 --> 01:23:59.576
- I know, five weeks.

01:23:59.576 --> 01:24:01.411
It's the first one I missed.

01:24:01.411 --> 01:24:02.871
(laughing)

01:24:02.871 --> 01:24:04.914
I guess if there's any
time for me to miss one

01:24:04.914 --> 01:24:06.750
it was probably the best time

01:24:06.750 --> 01:24:09.085
because it was probably
when I was least-

01:24:09.085 --> 01:24:11.087
- I've stopped
hounding you, hey.

01:24:11.087 --> 01:24:13.006
- That's what happened.
- You were getting aggravated.

01:24:13.006 --> 01:24:15.008
- This is all your
fault you realize.

01:24:15.008 --> 01:24:17.427
As my caretaker it's
your responsibility.

01:24:17.427 --> 01:24:20.680
- You were getting aggravated
with me mothering you.

01:24:20.680 --> 01:24:23.600
- I'm really, really lucky
with the family that I have.

01:24:23.600 --> 01:24:26.102
While it was probably
hard for her to know

01:24:26.102 --> 01:24:28.730
what I was going through
and see me do it,

01:24:28.730 --> 01:24:30.440
I think she did a good job

01:24:30.440 --> 01:24:31.983
of putting on a
brave face for me.

01:24:31.983 --> 01:24:33.651
(laughing)

01:24:33.651 --> 01:24:36.946
She's my mom and I'm
her baby. (laughing)

01:24:36.946 --> 01:24:39.616
So of course she's
gonna be scared

01:24:39.616 --> 01:24:42.368
with me going through
something like that.

01:24:42.368 --> 01:24:43.787
- Do you have the key?
- Yeah.

01:24:43.787 --> 01:24:46.456
- Okay.

01:24:47.957 --> 01:24:52.879
- We get to go home.
- I know, I know, Mama.

01:24:56.591 --> 01:24:59.552
- To take a position that
my child should risk death

01:24:59.552 --> 01:25:03.723
or blindness or loss of a kidney

01:25:03.723 --> 01:25:07.727
because someone else in
interpreting the Bible

01:25:07.727 --> 01:25:11.397
thinks that my child
shouldn't have that therapy

01:25:11.397 --> 01:25:15.151
is not part of this country.

01:25:15.151 --> 01:25:18.738
We have separation of the
church and the government.

01:25:18.738 --> 01:25:21.491
And my child has a doctor.

01:25:21.491 --> 01:25:24.744
There's scientists
that are advising us.

01:25:24.744 --> 01:25:29.124
If I'm gonna save his
life or my wife's life

01:25:30.667 --> 01:25:32.836
that's a line no
one should cross.

01:25:32.836 --> 01:25:36.673
My son, Jordan, if you
saw a picture of him

01:25:36.673 --> 01:25:38.925
the night of the
election for CIRM,

01:25:38.925 --> 01:25:40.885
he was jumping in the air.

01:25:40.885 --> 01:25:45.890
I mean, he was vibrant,
alive, hopeful, and excited.

01:25:46.850 --> 01:25:48.685
This was the future.

01:25:52.188 --> 01:25:54.858
Jordan was standing next to me.

01:25:56.109 --> 01:25:58.736
He believed this was the future.

01:26:01.739 --> 01:26:05.535
The issue is could we
get there fast enough?

01:26:05.535 --> 01:26:08.955
Type one diabetes took
his life this last year.

01:26:11.499 --> 01:26:13.668
I can't get back the seven years

01:26:13.668 --> 01:26:16.546
we lost with the
Bush administration

01:26:17.714 --> 01:26:19.507
but Jordan would

01:26:21.718 --> 01:26:24.596
absolutely be advocating that we

01:26:28.933 --> 01:26:30.852
drive this forward

01:26:30.852 --> 01:26:35.857
so other lives would
not be lost needlessly.

01:26:40.778 --> 01:26:42.864
He believed we'd get there,

01:26:42.864 --> 01:26:46.534
we just couldn't get
there fast enough for him.

01:26:49.537 --> 01:26:52.207
(upbeat music)

01:26:52.207 --> 01:26:54.709
- They infused the antibody.

01:26:54.709 --> 01:26:56.794
It was boring pretty much.

01:26:56.794 --> 01:27:01.257
This time, it was
a boring process.

01:27:02.634 --> 01:27:04.594
Nothing much happened.

01:27:04.594 --> 01:27:07.805
Ava didn't catch any
sicknesses, viruses,

01:27:07.805 --> 01:27:09.599
bacterial infections.

01:27:09.599 --> 01:27:12.268
The last transplant
we almost lost Ava,

01:27:12.268 --> 01:27:15.230
so I don't know what
we would've done

01:27:15.230 --> 01:27:17.899
if we went with
the chemo option.

01:27:17.899 --> 01:27:20.777
I don't even want to go there.

01:27:20.777 --> 01:27:24.030
♪ The wheels on the bus
go round and round ♪

01:27:24.030 --> 01:27:26.115
♪ All through the town

01:27:26.115 --> 01:27:27.825
Oh, careful, Ava.

01:27:27.825 --> 01:27:29.786
Careful, oh.

01:27:29.786 --> 01:27:31.996
Careful, you're gonna fall.

01:27:31.996 --> 01:27:34.707
Ava, do you want pancakes?

01:27:41.631 --> 01:27:46.135
But now so many months went
by and she's doing so well.

01:27:46.135 --> 01:27:48.304
We took her back
to family house.

01:27:48.304 --> 01:27:51.808
She was isolated for
another seven months.

01:27:51.808 --> 01:27:54.227
She didn't know what
outside looked like.

01:27:54.227 --> 01:27:55.853
She was just a baby.

01:27:55.853 --> 01:27:57.313
She would look
outside her window.

01:27:57.313 --> 01:28:00.191
And when she got outside
for the first time

01:28:00.191 --> 01:28:03.069
and I still remember,
it took a while for her

01:28:03.069 --> 01:28:06.739
to get used to the
noise, the people.

01:28:06.739 --> 01:28:09.659
It just felt like
everything was brand new.

01:28:10.618 --> 01:28:12.578
Let's go.

01:28:12.578 --> 01:28:13.997
Come on, please.

01:28:13.997 --> 01:28:16.124
Ava, no, you can't.

01:28:16.124 --> 01:28:19.669
You would always think you're
gonna have a healthy child

01:28:19.669 --> 01:28:21.629
and she's gonna go to school,

01:28:21.629 --> 01:28:23.256
be normal, play in the dirt.

01:28:23.256 --> 01:28:25.091
Play with friends outside.

01:28:26.217 --> 01:28:28.344
I mean, as a mother, it's just,

01:28:29.762 --> 01:28:31.889
(crying)

01:28:34.976 --> 01:28:38.354
I just don't know what I
would've done if I lost Ava.

01:28:41.691 --> 01:28:43.192
It's like wow.

01:28:44.736 --> 01:28:48.364
Ava fought so hard
and it just gives you

01:28:48.364 --> 01:28:51.200
the strength to
keep going in life

01:28:51.200 --> 01:28:55.705
and to give her the
best life possible.

01:28:57.790 --> 01:28:59.208
Ready?

01:28:59.208 --> 01:29:01.627
(laughing)

01:29:01.627 --> 01:29:02.754
Okay.
- Mommy.

01:29:02.754 --> 01:29:04.213
- Nope. We got to go back.

01:29:04.213 --> 01:29:05.840
We'll come back, okay?

01:29:05.840 --> 01:29:07.759
We'll come back. Please.

01:29:07.759 --> 01:29:10.345
We'll come back.

01:29:10.345 --> 01:29:12.847
Go get your shoes.

01:29:12.847 --> 01:29:15.058
It's all we think
about too is timing,

01:29:15.058 --> 01:29:17.226
timing, perfect timing.

01:29:17.226 --> 01:29:20.355
I feel like God was with
us during that time.

01:29:22.190 --> 01:29:24.150
- This is like Brooklyn
gardens, Violet.

01:29:24.150 --> 01:29:25.276
- Yeah.

01:29:25.276 --> 01:29:26.694
Go to the right, you guys.

01:29:26.694 --> 01:29:27.820
- The right?

01:29:27.820 --> 01:29:29.280
- A little bit. (laughing)

01:29:29.280 --> 01:29:30.948
- Over here?
- Yeah. Keep going that way.

01:29:30.948 --> 01:29:32.867
Oh yeah, it looks nice in there.

01:29:32.867 --> 01:29:34.202
- Oh, yeah.
- It's beautiful.

01:29:34.202 --> 01:29:35.828
- Yeah, beautiful.

01:29:35.828 --> 01:29:37.705
You gonna go first?
- May I go first?

01:29:37.705 --> 01:29:39.332
- Yeah. Okay.

01:29:39.332 --> 01:29:44.087
- Kelly, this 10 plus years.

01:29:44.962 --> 01:29:46.339
Beautiful.

01:29:50.343 --> 01:29:52.053
I'm starting to cry.

01:29:52.053 --> 01:29:54.263
- Don't start to cry, it's okay.

01:29:55.264 --> 01:29:57.433
- 10 plus years.

01:29:57.433 --> 01:29:59.811
It's beautiful what we have.

01:29:59.811 --> 01:30:02.730
The girls are wildly different

01:30:02.730 --> 01:30:07.693
and what we have made
perfect in their ways so far.

01:30:07.693 --> 01:30:11.155
And I love them so much.

01:30:11.155 --> 01:30:16.160
Kelly, you are the most
amazing human being.

01:30:17.745 --> 01:30:19.789
There are no words
to describe you.

01:30:21.124 --> 01:30:23.167
Thanks, babe.

01:30:24.877 --> 01:30:26.003
I mean it.

01:30:35.096 --> 01:30:36.764
- Okay.

01:30:36.764 --> 01:30:39.308
When I look back, I
marvel in amazement.

01:30:39.308 --> 01:30:41.853
I remember how happy I was.

01:30:41.853 --> 01:30:45.440
We had it made, we made it
through your sickness in 2007,

01:30:45.440 --> 01:30:47.275
the breakup in 2008,

01:30:47.275 --> 01:30:51.446
having our miracle baby, Violet,
Noelle, Christmas in July.

01:30:51.446 --> 01:30:55.491
I have never doubted
your commitment to
me or our daughters.

01:30:57.243 --> 01:30:59.787
Sometimes this year
because of turn of events,

01:30:59.787 --> 01:31:02.373
I thought that I wished
that we had never met

01:31:02.373 --> 01:31:05.001
because then I wouldn't
have to go through

01:31:05.001 --> 01:31:08.379
such fear and pain, but that
is just stupid and untrue.

01:31:08.379 --> 01:31:11.299
The past year may have
highlighted how brave

01:31:11.299 --> 01:31:14.343
and tough and good you are,
but you're just being you.

01:31:14.343 --> 01:31:17.180
It is because of how much
I love you in our life

01:31:17.180 --> 01:31:20.057
that I feel the bad
emotions so deeply as well.

01:31:20.057 --> 01:31:22.977
Being your wife and partner
and mother to these kids

01:31:22.977 --> 01:31:25.521
makes me more proud than
any other accomplishment

01:31:25.521 --> 01:31:28.107
or achievement or
anything else ever could.

01:31:28.107 --> 01:31:31.110
I love you and your
brain and I always will.

01:31:31.110 --> 01:31:33.362
And thank you for being our dad.

01:31:33.362 --> 01:31:36.032
(soft touching piano music)

01:31:44.207 --> 01:31:46.876
(Kelly laughing)

01:31:48.085 --> 01:31:50.421
- Everything has flowers on it.

01:31:50.421 --> 01:31:52.381
Whoa!

01:31:52.381 --> 01:31:54.258
- Oh, cool.

01:31:54.258 --> 01:31:56.219
- I'm gonna sprinkle the
sprinkles on it right now.

01:31:56.219 --> 01:31:57.386
- Awesome.

01:31:57.386 --> 01:31:58.846
(water running)

01:31:58.846 --> 01:32:00.556
- Sprinkles!

01:32:00.556 --> 01:32:01.891
- Oh, ho, ho.

01:32:03.267 --> 01:32:06.187
- I had that milk for
you that's right there.

01:32:10.900 --> 01:32:14.570
- Happy anniversary.
- Happy anniversary.

01:32:18.866 --> 01:32:22.203
There's a thing called the
Universal Anatomical Gift Act

01:32:22.203 --> 01:32:23.955
to give tissues

01:32:23.955 --> 01:32:27.458
from people who have just
died for biomedical research.

01:32:27.458 --> 01:32:30.962
So in the federal law or
the executive actions,

01:32:30.962 --> 01:32:33.923
we're allowed to use
fetal tissue for research

01:32:33.923 --> 01:32:35.800
with these guidelines.

01:32:35.800 --> 01:32:38.928
The guidelines were, not only
does the woman have to say,

01:32:38.928 --> 01:32:40.805
"I'm gonna have the abortion"

01:32:40.805 --> 01:32:42.974
and not be asked about anything

01:32:42.974 --> 01:32:47.979
about the disposition of the
parts until after the abortion,

01:32:49.230 --> 01:32:51.774
but neither she, nor the doctor,

01:32:51.774 --> 01:32:55.945
nor anybody else involved
with it can make money.

01:32:55.945 --> 01:32:59.490
Individual states in
our country have already

01:32:59.490 --> 01:33:01.867
banned the use of fetal tissues

01:33:01.867 --> 01:33:04.912
for research or therapies.

01:33:04.912 --> 01:33:06.789
Banned it.

01:33:06.789 --> 01:33:11.002
So people in their state
don't have the opportunities

01:33:11.002 --> 01:33:13.671
of people in adjoining states

01:33:13.671 --> 01:33:17.425
to have a chance for a therapy
that might save their lives

01:33:17.425 --> 01:33:21.304
or restore their vision or heal
their spinal cord injuries.

01:33:21.304 --> 01:33:22.888
In the early 2000s,

01:33:22.888 --> 01:33:25.683
when Governor
Brownback of Kansas

01:33:25.683 --> 01:33:29.020
proposed 10 years in jail,
a million dollar fine

01:33:29.020 --> 01:33:30.980
if you do the research.

01:33:30.980 --> 01:33:33.858
A million dollars
fine, 10 years in jail

01:33:33.858 --> 01:33:37.403
if you are a doctor
and prescribe a therapy

01:33:37.403 --> 01:33:39.530
that comes from that research.

01:33:39.530 --> 01:33:41.991
A million dollar
fine, 10 years in jail

01:33:41.991 --> 01:33:45.786
if you're a patient who left
the US to get that therapy,

01:33:45.786 --> 01:33:47.955
no matter how it turned out.

01:33:49.707 --> 01:33:54.003
For those who have the
chance to hold back a therapy

01:33:54.003 --> 01:33:56.922
based on their own private,
religious, political,

01:33:56.922 --> 01:33:59.383
moral, economic agreements.

01:33:59.383 --> 01:34:01.427
If they hold it
back from people,

01:34:01.427 --> 01:34:03.804
they're responsible
for the loss of lives

01:34:03.804 --> 01:34:06.432
of those who could
have been treated

01:34:06.432 --> 01:34:08.893
within that narrow
window of opportunity

01:34:08.893 --> 01:34:12.647
should the treatment
be safe and effective.

01:34:34.418 --> 01:34:36.379
- Good. Skip ahead.

01:34:36.379 --> 01:34:38.089
- I joined the gay men's chorus,

01:34:38.089 --> 01:34:40.925
which turned out to be
a pivotal moment for me

01:34:40.925 --> 01:34:44.095
because it gave me an
opportunity to sing

01:34:44.095 --> 01:34:46.972
and be a part of a really
great support system

01:34:46.972 --> 01:34:49.433
and a support network.

01:34:49.433 --> 01:34:53.437
(men singing choir music)

01:34:58.401 --> 01:35:01.112
- Yeah, that was it.
Good, good, good.

01:35:01.112 --> 01:35:02.947
All right. Let's move on.

01:35:02.947 --> 01:35:06.409
You'll remember Tim was
talking to us a month or so ago

01:35:06.409 --> 01:35:09.662
about what Andrew bravely
went through down in LA

01:35:09.662 --> 01:35:11.706
with the test and the research.

01:35:11.706 --> 01:35:15.042
And I'd like to actually
invite Andrew up.

01:35:15.042 --> 01:35:18.379
(audience applauding)

01:35:26.762 --> 01:35:29.390
- Don't make me sing,
don't make me sing.

01:35:29.390 --> 01:35:32.435
I don't want to sing.
(audience laughing)

01:35:34.019 --> 01:35:37.481
(stirring piano music)

01:35:37.481 --> 01:35:39.900
(choir singing)

01:35:39.900 --> 01:35:42.695
It's still kind of shocking
every time I say it,

01:35:42.695 --> 01:35:45.990
to be able to help
find a cure for HIV.

01:35:45.990 --> 01:35:48.451
This is pretty big.

01:35:49.660 --> 01:35:51.829
The HIV and AIDS epidemic,

01:35:51.829 --> 01:35:54.623
it hits pretty close to
home for a lot of people,

01:35:54.623 --> 01:35:57.752
particularly in the San
Francisco Gay Men's Chorus

01:35:57.752 --> 01:36:00.796
just 'cause there's so
many guys in the chorus

01:36:00.796 --> 01:36:04.633
who are long-time
survivors of HIV.

01:36:04.633 --> 01:36:07.928
Having to go through
the worst of it.

01:36:07.928 --> 01:36:11.015
♪ God help the outcasts

01:36:11.015 --> 01:36:14.477
♪ Hungry from birth

01:36:14.477 --> 01:36:17.730
♪ I thought we all were

01:36:17.730 --> 01:36:20.858
♪ The children of God

01:36:22.860 --> 01:36:25.446
(men singing)

01:36:28.032 --> 01:36:32.453
Seeing almost all of
their friends die.

01:36:32.453 --> 01:36:36.040
And they've buried husbands,
they've buried lovers,

01:36:36.040 --> 01:36:39.585
not knowing how many more
you're going to have to bury

01:36:39.585 --> 01:36:42.004
before there's
something that happens.

01:36:42.004 --> 01:36:44.965
♪ The children

01:36:52.640 --> 01:36:54.725
♪ Of

01:36:56.519 --> 01:37:00.022
Now it's a chronic condition
that people live with

01:37:00.022 --> 01:37:01.941
but it's still not easy.

01:37:01.941 --> 01:37:04.026
There's still people
who don't have

01:37:04.026 --> 01:37:06.070
easy accessibility
to medication.

01:37:07.238 --> 01:37:10.991
♪ Of God.

01:37:14.745 --> 01:37:17.581
- Beautiful.
- Thank you again.

01:37:17.581 --> 01:37:20.751
(audience applauding)

01:37:23.254 --> 01:37:26.590
- You're gonna come right
over here in room one.

01:37:26.590 --> 01:37:27.258
- Okay.

01:37:30.094 --> 01:37:31.971
- Hello, young lady.

01:37:31.971 --> 01:37:33.222
Makeup?

01:37:33.222 --> 01:37:34.515
(laughing)

01:37:34.515 --> 01:37:35.850
- How could you tell?

01:37:35.850 --> 01:37:37.685
- Because I can tell.

01:37:37.685 --> 01:37:38.936
'Cause I know, hi.

01:37:38.936 --> 01:37:40.896
- Because I don't look as tired

01:37:40.896 --> 01:37:43.023
as the last couple
of times I saw ya?

01:37:43.023 --> 01:37:47.027
- No, we refer to that as
a positive makeup sign.

01:37:47.027 --> 01:37:50.823
- Yeah, I cared less I
think then. (laughing)

01:37:54.577 --> 01:37:57.037
- Yeah, so this is your scan.
- Mm-hmm.

01:37:57.037 --> 01:37:58.664
- All right.

01:37:58.664 --> 01:38:01.125
What I can tell you is
nothing in the breasts,

01:38:01.125 --> 01:38:02.960
which would be here.

01:38:02.960 --> 01:38:06.130
And nothing in the lungs,
which you had before.

01:38:06.130 --> 01:38:08.966
And I don't see anything else.

01:38:08.966 --> 01:38:10.551
- Okay.

01:38:10.551 --> 01:38:12.261
- And that just begins to say

01:38:12.261 --> 01:38:14.638
well maybe we have
eliminated it.

01:38:14.638 --> 01:38:17.683
- And that it really
is gone this time.

01:38:17.683 --> 01:38:21.103
We are now at 53 days
after transplant.

01:38:21.103 --> 01:38:22.980
- Nice.

01:38:22.980 --> 01:38:25.107
- And 51 days therefore
after CAR T cell infusion.

01:38:25.107 --> 01:38:26.775
- Mm-hmm.
- Right?

01:38:28.110 --> 01:38:30.946
See, the days will turn
into number of weeks

01:38:30.946 --> 01:38:33.198
after transplant and
the weeks will turn

01:38:33.198 --> 01:38:35.826
into a number of
months after transplant

01:38:35.826 --> 01:38:39.914
and esperanza, it'll turn
into years after transplant.

01:38:39.914 --> 01:38:41.582
Yay.

01:38:41.582 --> 01:38:42.750
Right?
- Yeah.

01:38:42.750 --> 01:38:44.335
That's what I'm planning on.

01:38:44.335 --> 01:38:45.711
- It all looks good.

01:38:45.711 --> 01:38:47.171
Keep adding on the days.

01:38:47.171 --> 01:38:48.756
- Yeah.

01:38:48.756 --> 01:38:52.635
So this kind of new
therapy is not going to,

01:38:52.635 --> 01:38:56.263
yeah, just obliterate anything
in its path, good, bad.

01:38:56.263 --> 01:38:59.808
It's going to target
very specifically
that kind of cancer.

01:38:59.808 --> 01:39:03.020
So that's encouraging to think
that it could be something

01:39:03.020 --> 01:39:04.855
that just hangs out in my body

01:39:04.855 --> 01:39:06.357
and when I turn 70 that if

01:39:06.357 --> 01:39:09.068
this cancer is
trying to come back

01:39:09.068 --> 01:39:12.029
that I'll still have
those cells looking out

01:39:12.029 --> 01:39:15.240
and making sure that that
it's not gonna come back.

01:39:15.240 --> 01:39:16.951
- Deep breath.

01:39:16.951 --> 01:39:18.369
(Cheryl inhales)

01:39:18.369 --> 01:39:20.204
All right, you're good.

01:39:20.204 --> 01:39:22.247
Every breakthrough that we have

01:39:22.247 --> 01:39:25.709
and that pill, that
transplant, CAR T cells,

01:39:25.709 --> 01:39:28.212
every time we have that
successful therapy,

01:39:28.212 --> 01:39:33.050
I am flooded in my memory
of people I've taken care of

01:39:33.050 --> 01:39:36.261
over the last 40 years that

01:39:36.261 --> 01:39:39.306
had we known then
what we know now,

01:39:39.306 --> 01:39:41.225
would be around.

01:39:41.225 --> 01:39:44.687
And so I think that creates
a certain fire in the belly

01:39:44.687 --> 01:39:46.397
to act on their behalf

01:39:46.397 --> 01:39:49.066
and for the people that
are gonna be coming to us

01:39:49.066 --> 01:39:50.734
for care in the future.

01:39:50.734 --> 01:39:53.278
- Wow, that didn't look
like a legal throw in.

01:39:53.278 --> 01:39:55.406
- [Cheryl} It didn't, did
she lift her foot? Uh-oh.

01:39:55.406 --> 01:39:56.657
No, no, no!

01:39:56.657 --> 01:39:57.825
(laughing)

01:39:57.825 --> 01:40:00.744
- Seven and O.
- No, nice try.

01:40:00.744 --> 01:40:03.205
- I love it.
- We get a free kick.

01:40:03.205 --> 01:40:05.666
- Take it from
where it happened.

01:40:05.666 --> 01:40:07.251
- Oh, that was awesome.

01:40:08.836 --> 01:40:11.797
There's days that
you still think,

01:40:11.797 --> 01:40:15.843
oh, but I've read
such and such article

01:40:15.843 --> 01:40:18.303
and it says survival is dismal

01:40:18.303 --> 01:40:23.017
when diffuse large
B-cell lymphoma returns.

01:40:24.435 --> 01:40:27.229
God doesn't promise that
things are gonna be good

01:40:27.229 --> 01:40:29.398
and easy and smooth.

01:40:32.067 --> 01:40:35.237
And I'm gonna get emotional
just thinking about...

01:40:38.032 --> 01:40:41.285
For some reason,
beyond my knowledge

01:40:44.079 --> 01:40:46.832
he's allowed this into my life

01:40:47.833 --> 01:40:50.419
and I don't know why.

01:40:50.419 --> 01:40:52.379
Sometimes I see it as, hey,

01:40:52.379 --> 01:40:55.174
God chose me to be able
to have this cancer

01:40:55.174 --> 01:40:57.092
so that I can be used.

01:40:57.092 --> 01:40:59.762
You see God's handy
work in those things.

01:40:59.762 --> 01:41:02.097
These things don't
happen by chance.

01:41:03.182 --> 01:41:04.892
- I hope you don't mind

01:41:04.892 --> 01:41:07.394
that I put something
on Facebook already.

01:41:07.394 --> 01:41:09.313
- Oh, about the results?

01:41:09.313 --> 01:41:11.899
- Because there's a
lot of people praying

01:41:11.899 --> 01:41:13.400
and thinking about it.

01:41:13.400 --> 01:41:15.319
- Yeah, for sure.

01:41:15.319 --> 01:41:17.863
I know it's starting to
become one of those things

01:41:17.863 --> 01:41:20.991
that I feel like it
just happened and yet

01:41:20.991 --> 01:41:23.035
when I talk about it with people

01:41:23.035 --> 01:41:26.789
that it was a year and a half
ago that everything started,

01:41:26.789 --> 01:41:29.833
that seems, it's
been a long time.

01:41:29.833 --> 01:41:33.879
- Well, we'll always have
it in the back of our minds.

01:41:33.879 --> 01:41:36.507
- Well, so the
funny thing too is

01:41:36.507 --> 01:41:40.511
when we went to see Dr.
Forman for that second opinion

01:41:40.511 --> 01:41:42.346
last year, him saying,

01:41:42.346 --> 01:41:45.265
"Hey, if this ever for
any unfortunate reason

01:41:45.265 --> 01:41:49.853
that this comes back
that we want you here."

01:41:49.853 --> 01:41:52.856
- Knowing what we
know now, I mean,

01:41:52.856 --> 01:41:55.776
getting there probably
saved your life.

01:41:55.776 --> 01:41:57.444
- Yeah.

01:41:57.444 --> 01:41:59.780
- We won't know if it was
the CAR T cell therapy

01:41:59.780 --> 01:42:02.116
or whether it was a
stem cell transplant

01:42:02.116 --> 01:42:04.034
or whether it was both or.

01:42:04.034 --> 01:42:07.287
And the whole stem cell stuff,
it was really interesting.

01:42:07.287 --> 01:42:10.874
There's probably still
a lot of people that,

01:42:10.874 --> 01:42:13.377
maybe even your mom, (laughing)

01:42:13.377 --> 01:42:15.546
that would be more against

01:42:17.422 --> 01:42:21.051
some of the stem
cell controversy that
had been going on.

01:42:21.051 --> 01:42:24.054
Well, I mean, you said you
were against it earlier.

01:42:24.054 --> 01:42:25.973
- Well, yeah, I mean,

01:42:25.973 --> 01:42:30.102
because of how it
was presented to me

01:42:30.102 --> 01:42:33.564
or I guess, the things
that I chose to listen to

01:42:33.564 --> 01:42:36.066
or hear was just-
- Well, how was that?

01:42:36.066 --> 01:42:40.404
- Was just that it involved
aborted fetal tissue.

01:42:41.947 --> 01:42:45.909
And you get the idea in
your head that, okay,

01:42:45.909 --> 01:42:49.580
people are having
abortions, even so,

01:42:49.580 --> 01:42:53.959
you know, the stem
cells from a baby

01:42:53.959 --> 01:42:58.881
in that case can still be used
for something very important.

01:43:00.465 --> 01:43:03.594
But I didn't think
about that at that time.

01:43:03.594 --> 01:43:08.223
It was just more concerned
about the abortion issue.

01:43:08.223 --> 01:43:11.351
- Stem cell research has
been really, really important

01:43:11.351 --> 01:43:12.895
and I don't think...

01:43:12.895 --> 01:43:15.230
I would fall more in line with

01:43:15.230 --> 01:43:17.316
we should be able
to do research.

01:43:17.316 --> 01:43:21.069
I mean, I don't think it
causes more abortions or it...

01:43:22.112 --> 01:43:24.072
or anything like that,

01:43:24.072 --> 01:43:27.993
but I believe that
your treatment,

01:43:27.993 --> 01:43:30.579
there's still part
of that that's,

01:43:30.579 --> 01:43:33.081
I don't know, miraculous.

01:43:33.081 --> 01:43:34.958
- Uh huh.

01:43:34.958 --> 01:43:37.461
- Like I feel like, we
think of biblical stories

01:43:37.461 --> 01:43:39.421
of Jesus doing miracles.

01:43:39.421 --> 01:43:42.883
And we say, "Well, we don't
really see that very often.

01:43:42.883 --> 01:43:46.011
We don't see miracles,
but in a lot of ways

01:43:46.011 --> 01:43:48.972
it is miraculous that
God gives human beings

01:43:48.972 --> 01:43:52.267
the capacity to develop
these types of procedures

01:43:52.267 --> 01:43:54.186
and this type of treatment.

01:43:54.186 --> 01:43:56.438
And I thought about,
like it's a legacy

01:43:56.438 --> 01:43:58.482
of pretty remarkable things that

01:43:58.482 --> 01:44:02.319
I see God's hand in.
- Yeah.

01:44:02.319 --> 01:44:04.238
- I wouldn't say it's just

01:44:04.238 --> 01:44:08.367
by man's own abilities
and intelligence.

01:44:08.367 --> 01:44:10.160
- No.
- So yeah.

01:44:10.160 --> 01:44:14.998
I think it's still miraculous
that like you said,

01:44:14.998 --> 01:44:18.335
that cancer isn't
a death sentence.

01:44:18.335 --> 01:44:19.419
- Mm-hmm.

01:44:21.004 --> 01:44:23.674
So yeah, now I'm ready
to put this behind and

01:44:25.676 --> 01:44:30.180
never look at it, well, not
never look at it again, but-

01:44:30.180 --> 01:44:31.598
- Well, it'd be nice-

01:44:31.598 --> 01:44:34.685
- Just not to have
to deal with cancer

01:44:34.685 --> 01:44:37.437
for myself again, or
anybody else. (laughing)

01:44:37.437 --> 01:44:38.313
- Yeah.

01:44:47.030 --> 01:44:49.533
It's nice out.
- I know, it is.

01:44:55.122 --> 01:44:57.374
(upbeat music)

01:44:57.374 --> 01:45:00.585
- Yeah, I find it.
- Where's hospital?

01:45:00.585 --> 01:45:02.212
- Over here.

01:45:02.212 --> 01:45:04.423
- Hold on, Daddy's
gonna put you down.

01:45:04.423 --> 01:45:06.550
- Okay.

01:45:06.550 --> 01:45:08.552
- You gotta put this on, Ava.

01:45:08.552 --> 01:45:10.554
- Put your face mask on.

01:45:20.522 --> 01:45:22.733
- Come on, hold hands.

01:45:22.733 --> 01:45:24.651
Let's go.

01:45:24.651 --> 01:45:28.030
- We were so excited and we
told the news to our family.

01:45:28.030 --> 01:45:30.365
We're like, "Ava
has three B-cells,"

01:45:30.365 --> 01:45:33.243
and they're like, "Oh my God."

01:45:33.243 --> 01:45:34.745
We're all so excited for her.

01:45:34.745 --> 01:45:37.205
And the last test I remember

01:45:37.205 --> 01:45:39.416
of when she had the
highest B-cells,

01:45:39.416 --> 01:45:42.127
she had about 15, 20 B-cells.

01:45:43.712 --> 01:45:46.048
Hey.
- My purse!

01:45:52.346 --> 01:45:55.682
- You have a lot of drama
following you guys around.

01:45:55.682 --> 01:45:58.143
You're pretty famous,
you know that?

01:45:59.227 --> 01:46:01.605
Yeah, we're certainly optimistic

01:46:01.605 --> 01:46:04.775
that Ava's gonna be a
pioneer in this field

01:46:04.775 --> 01:46:08.779
or that someday we are gonna
be able to do all of this

01:46:08.779 --> 01:46:12.574
just with antibodies or other
small molecule inhibitors

01:46:12.574 --> 01:46:15.535
that aren't fancy poisons.

01:46:15.535 --> 01:46:17.621
So since you guys went home,

01:46:17.621 --> 01:46:20.457
no hospitalizations
for anything?

01:46:20.457 --> 01:46:22.125
- No.
- That's good.

01:46:22.125 --> 01:46:23.668
- I know, it's really good.

01:46:23.668 --> 01:46:25.629
- That, I think is great news.

01:46:25.629 --> 01:46:28.548
So her CD4 count's up to 632,

01:46:28.548 --> 01:46:32.511
which is, yeah, that's
like really good for her.

01:46:32.511 --> 01:46:34.805
So that's good.
- Aw, sweet.

01:46:37.224 --> 01:46:40.310
- In a bone marrow transplant,
people are really taken

01:46:40.310 --> 01:46:42.396
to a near-death experience.

01:46:42.396 --> 01:46:44.523
As a physician who
treats patients

01:46:44.523 --> 01:46:49.361
who have these complications,
it is heartbreaking.

01:46:49.361 --> 01:46:51.488
And everyone is excited.

01:46:51.488 --> 01:46:54.366
It's like, it just drives us.

01:46:54.366 --> 01:46:56.827
It's sort of like
this undercurrent

01:46:56.827 --> 01:46:58.662
that's part of our life now.

01:46:58.662 --> 01:47:01.832
it's possible that we
could really be doing it,

01:47:01.832 --> 01:47:05.669
making a difference so that
we're gonna see the last days

01:47:05.669 --> 01:47:08.755
of chemotherapy in the
next couple of years.

01:47:11.633 --> 01:47:12.843
(crowd chattering)

01:47:12.843 --> 01:47:15.178
- Ladies and gentlemen,

01:47:15.178 --> 01:47:17.347
please turn your
attention to the field

01:47:17.347 --> 01:47:19.516
as we welcome Lucas Lindner

01:47:19.516 --> 01:47:22.185
who was in an automobile
accident last year

01:47:22.185 --> 01:47:24.855
and suffered a severe
spinal cord injury

01:47:24.855 --> 01:47:27.816
that left him paralyzed
from the neck down.

01:47:27.816 --> 01:47:31.319
Lucas received an innovative
therapy several weeks

01:47:31.319 --> 01:47:34.364
after the accident as
part of a clinical study.

01:47:34.364 --> 01:47:36.616
In fact, he is one
of only five people

01:47:36.616 --> 01:47:39.661
in the United States who
has received this therapy.

01:47:39.661 --> 01:47:41.455
Since the surgery,

01:47:41.455 --> 01:47:44.207
Lucas has regained
significant functional use

01:47:44.207 --> 01:47:46.126
of his arms and hands.

01:47:46.126 --> 01:47:50.380
(audience applauding
and cheering)

01:47:50.380 --> 01:47:53.550
(uplifting music)

01:47:53.550 --> 01:47:56.720
- It's literally the
difference between

01:47:57.721 --> 01:48:01.141
being a vegetable

01:48:01.141 --> 01:48:06.146
and doing what I've wanted
to do my entire life.

01:48:07.522 --> 01:48:10.567
I absolutely loved
building computers,

01:48:10.567 --> 01:48:12.527
building networks,

01:48:12.527 --> 01:48:15.697
and doing network
infrastructure.

01:48:15.697 --> 01:48:17.782
Hey, Grandma?
- Yeah.

01:48:17.782 --> 01:48:21.369
- Do you have a
college ruled notebook?

01:48:21.369 --> 01:48:23.246
- Yes.
- Thank you.

01:48:23.246 --> 01:48:25.874
Before the transplant
I could shrug

01:48:25.874 --> 01:48:28.376
and that was about it.

01:48:28.376 --> 01:48:29.920
Yeah, that'll work. Thanks.

01:48:33.715 --> 01:48:35.717
And then when you can do this

01:48:37.594 --> 01:48:40.430
and that's the doctor pretty
much falls off his chair and

01:48:41.890 --> 01:48:43.934
doesn't know what to say.

01:48:45.602 --> 01:48:47.812
- If I would've
made that prediction

01:48:47.812 --> 01:48:49.898
the week after he was injured,

01:48:49.898 --> 01:48:52.442
the day before I did my surgery

01:48:52.442 --> 01:48:54.945
to transplant these cells,

01:48:54.945 --> 01:48:56.863
I would've gotten laughed at

01:48:56.863 --> 01:48:58.823
as would most other surgeons

01:48:58.823 --> 01:49:01.451
who might've made
that same prediction.

01:49:01.451 --> 01:49:04.246
So as they say, the
proof is in the pudding.

01:49:04.246 --> 01:49:05.872
And so this time though,

01:49:05.872 --> 01:49:08.500
there was no arguing
the results here.

01:49:08.500 --> 01:49:10.335
Through medical school,

01:49:10.335 --> 01:49:13.296
being told there is no
regenerative possibility

01:49:13.296 --> 01:49:14.965
for the nervous system,

01:49:14.965 --> 01:49:17.884
to see something so
obvious was a big deal.

01:49:19.511 --> 01:49:21.972
I was one of the
big skeptics first,

01:49:21.972 --> 01:49:24.766
but almost every single
one of the patients

01:49:24.766 --> 01:49:26.643
that have received cells

01:49:26.643 --> 01:49:28.603
has improved substantially.

01:49:28.603 --> 01:49:30.981
And so I think that
there is a hope

01:49:30.981 --> 01:49:34.901
that if you are able
to create regeneration

01:49:34.901 --> 01:49:39.573
across a small length of
the bruised spinal cord,

01:49:39.573 --> 01:49:42.576
there isn't any reason
why with refinements

01:49:42.576 --> 01:49:45.704
we can't restore the
person to where they were.

01:49:45.704 --> 01:49:49.332
Obviously that's a
way away at this point

01:49:49.332 --> 01:49:51.835
but I think that
door is open now.

01:49:58.675 --> 01:50:01.636
I mean, just to take a man

01:50:01.636 --> 01:50:05.599
that was dependent on
somebody for everything,

01:50:05.599 --> 01:50:09.519
to somebody who is going
to be useful in society,

01:50:09.519 --> 01:50:11.521
we're seeing the miracle

01:50:11.521 --> 01:50:14.691
right in front of our
eyes day after day.

01:50:16.026 --> 01:50:18.361
- Are we going to
the same rooms today?

01:50:18.361 --> 01:50:19.487
- What's that?

01:50:19.487 --> 01:50:20.989
- Are we doing the same-

01:50:20.989 --> 01:50:22.866
- Yeah, same old thing. Exactly.

01:50:22.866 --> 01:50:25.910
So what is happening in
your little world here?

01:50:25.910 --> 01:50:27.621
What's changes?
- Okay.

01:50:27.621 --> 01:50:29.539
It was Alessandro's
last day of school,

01:50:29.539 --> 01:50:31.791
I'm waiting for the shuttle
to come pick him up.

01:50:31.791 --> 01:50:34.461
And I have this little hole
about yay big on the door

01:50:34.461 --> 01:50:36.338
and I opened the door

01:50:36.338 --> 01:50:38.006
and I'm looking out to
see, okay, what can I see?

01:50:38.006 --> 01:50:39.966
And I always start
with my worse eye.

01:50:39.966 --> 01:50:41.885
So my untreated
eye, I covered it,

01:50:41.885 --> 01:50:44.429
looked out and I'm
kind of looking around.

01:50:44.429 --> 01:50:46.806
It was really tough
to make things out.

01:50:46.806 --> 01:50:49.768
- And then I knew German
had put out five trash cans

01:50:49.768 --> 01:50:51.811
and I'm desperately
trying so hard to see

01:50:51.811 --> 01:50:53.897
if I could make out
five trash cans.

01:50:53.897 --> 01:50:55.690
Switched eye, looked out,

01:50:55.690 --> 01:50:58.735
clearly saw one, two,
three, four, five.

01:50:58.735 --> 01:51:00.403
- Oh my gosh. Like right away?

01:51:00.403 --> 01:51:01.863
- Yeah, I saw five.

01:51:01.863 --> 01:51:03.740
- So just switched
over to the left eye

01:51:03.740 --> 01:51:05.408
the treated eye and boom,

01:51:05.408 --> 01:51:07.911
- They were lined up
in a row and I'm like,

01:51:07.911 --> 01:51:09.579
holy cow, I saw all five.

01:51:09.579 --> 01:51:10.914
Oh my gosh, oh my gosh.

01:51:10.914 --> 01:51:12.582
- Wow.

01:51:12.582 --> 01:51:13.416
- And I obviously
use my sweet spot.

01:51:13.416 --> 01:51:15.085
- Of course.

01:51:15.085 --> 01:51:16.961
- But my sweet spot is
huge now. I mean, it's big.

01:51:16.961 --> 01:51:19.089
- The sweet spot is
continuing to grow

01:51:19.089 --> 01:51:21.007
and get larger and
increase. Fantastic.

01:51:21.007 --> 01:51:22.884
- There's the new thing is that

01:51:22.884 --> 01:51:25.887
there's a sliver of my
central vision if I look up,

01:51:25.887 --> 01:51:27.931
I can see something right here.

01:51:27.931 --> 01:51:29.057
- Okay.

01:51:29.057 --> 01:51:30.684
- Right now, it's a little fuzzy

01:51:30.684 --> 01:51:32.769
but at least I know that
there is vision there.

01:51:32.769 --> 01:51:33.937
- Right.

01:51:33.937 --> 01:51:35.689
- Whereas before there wasn't.

01:51:35.689 --> 01:51:37.941
- Okay. Wonderful.
(laughing) That's fantastic.

01:51:37.941 --> 01:51:39.067
- Huge.

01:51:39.067 --> 01:51:41.111
- I think also she said

01:51:41.111 --> 01:51:44.406
she could see me out
of her peripheral

01:51:44.406 --> 01:51:46.866
and I think I was, I don't know,

01:51:46.866 --> 01:51:50.412
grabbing like the
Nutella or something.

01:51:50.412 --> 01:51:53.498
And she said, "Don't
grab that Nutella."

01:51:53.498 --> 01:51:55.959
I'm like, "Mom, wait.
No. How do you know?"

01:51:55.959 --> 01:51:57.919
And she's like, "I can see you."

01:51:57.919 --> 01:52:01.798
- It's the face. You walk
past her and you're like.

01:52:02.966 --> 01:52:04.634
- Okay.

01:52:05.969 --> 01:52:07.971
I call them my
seeing eye daughters

01:52:07.971 --> 01:52:09.848
because they're really good.

01:52:09.848 --> 01:52:12.475
I mean, we're walking
along and they'll tell me,

01:52:12.475 --> 01:52:14.144
"Oh, step up, step down, duck."

01:52:14.144 --> 01:52:15.478
(laughing)

01:52:15.478 --> 01:52:16.855
I mean, they're really good.

01:52:18.690 --> 01:52:20.942
You know what's neat is
that I can see you girls.

01:52:20.942 --> 01:52:22.152
- Aw.
- You can?

01:52:22.152 --> 01:52:23.820
- I can, I can see you.

01:52:23.820 --> 01:52:25.655
Out of a sliver of
my central vision

01:52:25.655 --> 01:52:27.073
and most of my periphery,

01:52:27.073 --> 01:52:28.700
I can see you.

01:52:28.700 --> 01:52:30.076
- No. A silver of
your peripheral

01:52:30.076 --> 01:52:31.995
and then most of your heart.

01:52:31.995 --> 01:52:33.663
- Oh, yeah.

01:52:33.663 --> 01:52:35.165
Well before it was
like 90% my heart

01:52:35.165 --> 01:52:37.792
and maybe 10% blurry,

01:52:37.792 --> 01:52:40.128
but I can see you girls.

01:52:40.128 --> 01:52:42.964
If I look at Dad, I can see you.

01:52:42.964 --> 01:52:45.842
It's something that
everyone else who has it

01:52:45.842 --> 01:52:47.427
takes for granted.

01:52:47.427 --> 01:52:49.137
I mean, life's hard
enough as it is

01:52:49.137 --> 01:52:52.015
but without vision,
it's even harder.

01:52:57.020 --> 01:52:59.189
- Aw, look at that.

01:52:59.189 --> 01:53:01.149
- Okay.
- Chicken.

01:53:01.149 --> 01:53:02.984
- Yeah, it's chicken.

01:53:02.984 --> 01:53:06.196
And now listen, do you
need anything cut up?

01:53:06.196 --> 01:53:08.198
Do you need the chicken cut?

01:53:08.198 --> 01:53:09.616
You got it? Okay.

01:53:09.616 --> 01:53:11.075
- I love chicken.

01:53:11.075 --> 01:53:12.869
- You love chicken?

01:53:12.869 --> 01:53:14.829
- Do you have that?

01:53:14.829 --> 01:53:16.831
That's yucky.

01:53:16.831 --> 01:53:18.666
- Oh, that's yucky, huh?

01:53:18.666 --> 01:53:20.502
You don't know.
- No.

01:53:20.502 --> 01:53:22.045
- Mm-mm.
- Mm-mm.

01:53:23.755 --> 01:53:25.507
- There you go.

01:53:25.507 --> 01:53:26.716
Good bite.

01:53:28.510 --> 01:53:31.095
It's good, right?
- Mm-hmm.

01:53:31.095 --> 01:53:33.014
(Kelly sighs)

01:53:34.641 --> 01:53:36.893
(Steve and Summer laugh)

01:53:42.649 --> 01:53:43.817
- All right.

01:53:48.029 --> 01:53:50.824
- I want chicken,
I want chicken.

01:53:52.492 --> 01:53:54.661
I want chicken, I want chicken.

01:53:54.661 --> 01:53:57.205
- Okay, that's a kid who
likes a lot of chicken, right?

01:53:57.205 --> 01:53:59.249
- I want chicken.

01:53:59.249 --> 01:54:01.793
I want chicken, I want chicken.

01:54:01.793 --> 01:54:03.628
- Okay.
- Thank you.

01:54:03.628 --> 01:54:04.921
- Take a good bite.

01:54:04.921 --> 01:54:06.840
Yes, ma'am. Not the whole thing.

01:54:06.840 --> 01:54:08.591
Okay, not the whole thing.

01:54:08.591 --> 01:54:09.801
Try to bite it in half.

01:54:09.801 --> 01:54:11.010
Okay. There you go.

01:54:11.010 --> 01:54:12.595
Bite it in half.

01:54:12.595 --> 01:54:14.597
All right, whatever.
Make it work.

01:54:16.891 --> 01:54:19.686
Yo. (laughing)

01:54:24.816 --> 01:54:26.943
- Oopsie, Daddy.

01:54:29.779 --> 01:54:32.615
- I love you.
- I love you too.

01:54:34.284 --> 01:54:36.619
- I'm super tired.
- Mm-hmm.

01:54:38.621 --> 01:54:40.665
My thing is that

01:54:41.791 --> 01:54:44.794
De qualify.

01:54:46.963 --> 01:54:50.133
De classify, de qualify.

01:54:50.133 --> 01:54:51.718
De, de...

01:54:54.262 --> 01:54:56.806
De qualify, you know?

01:54:58.808 --> 01:55:00.643
- Like, that it...

01:55:04.188 --> 01:55:05.982
- De qualify...

01:55:08.192 --> 01:55:10.987
- I have to check the
water for the noodles.

01:55:19.662 --> 01:55:20.788
- Hi.

01:55:24.125 --> 01:55:27.337
Oy-yoy, do you have wet hands?

01:55:27.337 --> 01:55:29.213
Cold hands?

01:55:29.213 --> 01:55:31.591
Daddy has cold hands.

01:55:31.591 --> 01:55:33.092
Daddy has cold hands.

01:55:33.092 --> 01:55:35.136
- Daddy has cold hands?

01:55:38.681 --> 01:55:41.017
- This professor,
what's his name?

01:55:41.017 --> 01:55:42.644
Well, I may not email him,

01:55:42.644 --> 01:55:45.855
but I'm gonna help you
email the guy, Ryan.

01:55:45.855 --> 01:55:47.732
- Parentheses,
there are two things

01:55:47.732 --> 01:55:49.651
I want to be clear about.

01:55:49.651 --> 01:55:52.362
First, if you do poorly
on the retake of the final

01:55:52.362 --> 01:55:54.697
it could pull your
grade down to an F.

01:55:54.697 --> 01:55:57.700
Parentheses, you really
just squeaked by with a D.

01:55:57.700 --> 01:56:00.870
Second, I do not think it is
fair to do anything additional

01:56:00.870 --> 01:56:02.747
allowing another retake,

01:56:02.747 --> 01:56:06.209
so your grade of this retake
will be your course grade.

01:56:06.209 --> 01:56:08.628
- That's ridiculous.

01:56:08.628 --> 01:56:10.046
That, you know what?

01:56:10.046 --> 01:56:12.382
The reason I was ill
prepared for the exam

01:56:12.382 --> 01:56:14.842
was because I didn't
have a textbook

01:56:14.842 --> 01:56:17.095
because I couldn't
come back to school

01:56:17.095 --> 01:56:20.056
'cause I had a C5 vertebrae
injury, you jackass.

01:56:20.056 --> 01:56:22.684
And you tell me it's
unfair to the other kids.

01:56:22.684 --> 01:56:24.394
Over a freaking economics class.

01:56:24.394 --> 01:56:26.020
That's a bunch of bullshit.

01:56:26.020 --> 01:56:27.730
- I think my teacher's
argument is that

01:56:27.730 --> 01:56:29.273
I should be a little
smarter than I am.

01:56:29.273 --> 01:56:31.234
- Well, that's all
of our arguments.

01:56:31.234 --> 01:56:33.111
Trust me.

01:56:33.111 --> 01:56:36.280
- I mean, do these jackasses
know what the hell's going on?

01:56:36.280 --> 01:56:38.783
You had a B going in,
you missed the exam

01:56:38.783 --> 01:56:40.910
because you got hurt,
you're paralyzed

01:56:40.910 --> 01:56:43.287
- I may have had a B,
we're not sure yet.

01:56:45.123 --> 01:56:47.000
I didn't say I had a B, I
said I probably had a B.

01:56:47.000 --> 01:56:48.418
- You probably had to B.

01:56:48.418 --> 01:56:50.420
So you really probably had what?

01:56:50.420 --> 01:56:52.088
A C minus, is that what you're?

01:56:52.088 --> 01:56:54.424
I mean, that changes
the scope of everything.

01:56:54.424 --> 01:56:57.093
I was in the impression
you had to B going in.

01:56:57.093 --> 01:57:00.680
- So was I but looking back
on it now, I don't know.

01:57:00.680 --> 01:57:03.725
- 43 on the midterm.

01:57:03.725 --> 01:57:06.436
- 43, you got a 43 on a midterm?

01:57:06.436 --> 01:57:08.855
- Yeah, it was hard.
- Before you got hurt?

01:57:08.855 --> 01:57:10.732
- Yeah, that's how
hard this class is.

01:57:10.732 --> 01:57:12.984
- And you think you
got a B in the class?

01:57:12.984 --> 01:57:14.902
- Well, there's stuff that are,

01:57:14.902 --> 01:57:16.362
there's papers and stuff that
are involved in this class.

01:57:16.362 --> 01:57:18.990
- I mean, you get
a 43 on a midterm

01:57:18.990 --> 01:57:21.159
and I'm sitting here
getting all worked up

01:57:21.159 --> 01:57:22.452
over your fricking D.

01:57:22.452 --> 01:57:24.370
Maybe did deserve a D.

01:57:24.370 --> 01:57:26.205
- I didn't deserve a D.

01:57:26.205 --> 01:57:28.124
It was demoralizing though.

01:57:28.124 --> 01:57:31.127
I think I cried when I got a
43, that was so demoralizing.

01:57:31.127 --> 01:57:33.171
- There's no way
you had a B at 43.

01:57:33.171 --> 01:57:35.465
- No, well I didn't have
the balls to tell you

01:57:35.465 --> 01:57:37.008
that I didn't have a B.

01:57:37.008 --> 01:57:38.301
Just couldn't do that to you.

01:57:38.301 --> 01:57:40.136
- You're in college now, dude,

01:57:40.136 --> 01:57:42.972
we're not gonna ground
you because you get a 43.

01:57:42.972 --> 01:57:46.184
- Well, I'm home now
so I can be grounded.

01:57:46.184 --> 01:57:49.270
My dad, he's always been
wanting for us to work hard.

01:57:49.270 --> 01:57:52.106
So I mean, obviously I
think coming into that test,

01:57:52.106 --> 01:57:54.233
he knew I wasn't
gonna do very well,

01:57:54.233 --> 01:57:57.904
but yeah, he'll get it over.
It will be totally fine.

01:57:57.904 --> 01:58:02.033
- We've known about
paralysis for 5,000 years,

01:58:02.033 --> 01:58:04.243
but we haven't made any progress

01:58:04.243 --> 01:58:08.831
in actually curing the
paralysis until now.

01:58:08.831 --> 01:58:12.335
I foresee a time
when paralyzed people

01:58:12.335 --> 01:58:15.004
will be fully functional.

01:58:16.172 --> 01:58:18.049
- We're not done
with stem cells.

01:58:18.049 --> 01:58:21.385
I mean, he's in a situation
where he could get some benefit

01:58:21.385 --> 01:58:23.262
from stem cells, who knows?

01:58:23.262 --> 01:58:25.765
Two years, five years,
10 years from now,

01:58:25.765 --> 01:58:27.308
because wherever it's going,

01:58:27.308 --> 01:58:29.268
I believe if he
can't walk right now,

01:58:29.268 --> 01:58:31.145
I truly believe in his lifetime,

01:58:31.145 --> 01:58:33.815
if again, we can keep
research with stem cells,

01:58:33.815 --> 01:58:35.024
I think he will walk.

01:58:35.024 --> 01:58:36.484
I think a lot of
people will walk

01:58:36.484 --> 01:58:38.820
who have no hope right now.

01:58:38.820 --> 01:58:40.947
- Since she's thriving
and doing well

01:58:40.947 --> 01:58:44.033
I mean really we haven't seen
any side effects from this,

01:58:44.033 --> 01:58:45.868
which is nice.

01:58:45.868 --> 01:58:48.496
So she's cleared for school
from our perspective.

01:58:48.496 --> 01:58:51.082
I mean, if you want
to keep her home,

01:58:51.082 --> 01:58:53.167
that's your decision,

01:58:53.167 --> 01:58:56.170
but our recommendation
would be to let her go.

01:58:56.170 --> 01:58:59.090
- We're being
introduced to something

01:58:59.090 --> 01:59:02.093
that's saving our
daughter's life.

01:59:02.093 --> 01:59:04.220
And we're also praying on it.

01:59:05.555 --> 01:59:08.099
There's no way I could
say no to science,

01:59:08.099 --> 01:59:10.059
but then no to our religion,

01:59:10.059 --> 01:59:12.937
because they both
have a meaning to us.

01:59:12.937 --> 01:59:14.856
It saved our daughter's life,

01:59:14.856 --> 01:59:18.359
but also I feel like our
beliefs and our culture,

01:59:18.359 --> 01:59:22.238
our religion did also
play a role in it as well.

01:59:24.073 --> 01:59:27.243
- Hopefully, someday this
drug is gonna pave the way

01:59:27.243 --> 01:59:30.079
of getting rid of
chemotherapy altogether.

01:59:30.079 --> 01:59:34.041
And then they're gonna say,
"In the days before Ava,

01:59:34.041 --> 01:59:35.918
patients got chemo

01:59:35.918 --> 01:59:39.046
and then she started
a revolution."

01:59:39.046 --> 01:59:40.256
- Oh.

01:59:40.256 --> 01:59:41.883
You're sweet, baby.

01:59:41.883 --> 01:59:43.593
- Ready?
- Hey, wait a minute,

01:59:43.593 --> 01:59:45.219
Wait a minute.

01:59:45.219 --> 01:59:46.470
Wait a minute, wait a minute.

01:59:46.470 --> 01:59:48.556
(laughing)

01:59:48.556 --> 01:59:51.392
- One.
- One.

01:59:51.392 --> 01:59:54.395
Two, three, four, five,

01:59:54.395 --> 01:59:58.107
six, seven, eight, nine.

01:59:58.107 --> 02:00:00.860
Ten. Eleven, twelve, thirteen.

02:00:00.860 --> 02:00:03.154
- Yeah!
- Yay, I did it!

02:00:04.572 --> 02:00:06.199
Goodnight, Mommy.

02:00:06.199 --> 02:00:08.451
- Goodnight, do want
your pink blanket?

02:00:08.451 --> 02:00:09.285
- Yeah.

02:00:09.285 --> 02:00:11.287
(soft music)

02:00:12.872 --> 02:00:15.166
- I'm a Trekkie and
in the old Star Trek

02:00:15.166 --> 02:00:18.169
there's a line where
Bones, the doctor,

02:00:18.169 --> 02:00:20.338
tells James Kirk and he goes,

02:00:20.338 --> 02:00:23.216
I guess they go back in
time and they're talking

02:00:23.216 --> 02:00:25.384
about medicine and
he's talking about,

02:00:25.384 --> 02:00:27.136
"Oh yeah, medicine. You know

02:00:27.136 --> 02:00:29.472
In those old days it was awful.

02:00:29.472 --> 02:00:31.599
We did monstrous,
terrible things.

02:00:31.599 --> 02:00:33.559
We gave people poison."

02:00:33.559 --> 02:00:36.187
He goes, "Oh, medicine,
it was just awful."

02:00:36.187 --> 02:00:38.272
I'm thinking, whoa,
if I could just be

02:00:38.272 --> 02:00:40.149
in that period of time

02:00:40.149 --> 02:00:42.944
where I don't have to say
that anymore, it'd be great.

02:00:45.529 --> 02:00:49.158
- The families and the
individuals in the state,

02:00:49.158 --> 02:00:52.453
they have a legacy 'cause
they've changed history.

02:00:52.453 --> 02:00:54.914
The important thing is that

02:00:56.249 --> 02:00:58.334
we get there fast enough
for their families.

02:00:59.502 --> 02:01:01.087
(sighs)

02:01:01.087 --> 02:01:03.547
A loss is something
you can never

02:01:03.547 --> 02:01:05.508
totally come to terms with,

02:01:06.550 --> 02:01:09.387
but there's only one choice.

02:01:12.682 --> 02:01:15.559
You can't abandon
the moral obligation

02:01:18.521 --> 02:01:20.523
to move forward

02:01:20.523 --> 02:01:23.609
when you understand
how many other Jordan's

02:01:28.322 --> 02:01:30.324
(sighs)

02:01:31.367 --> 02:01:33.035
can be saved.

02:01:36.372 --> 02:01:39.375
So the best I can do for Jordan

02:01:41.210 --> 02:01:42.628
is to make certain

02:01:42.628 --> 02:01:47.550
that every other child
with type one diabetes,

02:01:49.010 --> 02:01:51.721
every other person

02:01:51.721 --> 02:01:54.307
who's paralyzed as a young man

02:01:54.307 --> 02:01:57.476
or every other young
woman who's blind

02:01:59.228 --> 02:02:04.233
has this remarkable chance
to change their life

02:02:06.068 --> 02:02:08.154
and their family's life.

02:02:09.530 --> 02:02:11.240
That's the only option.

02:02:12.199 --> 02:02:14.118
That's the moral choice.

02:02:17.038 --> 02:02:18.622
- Hey there.
- Hi.

02:02:18.622 --> 02:02:20.416
What?
- You look lovely.

02:02:20.416 --> 02:02:21.625
(laughing)

02:02:21.625 --> 02:02:22.752
All right, hi guys.
- Hi.

02:02:22.752 --> 02:02:24.462
How are you?
- Good.

02:02:24.462 --> 02:02:26.505
- Last year when I had gone in,

02:02:26.505 --> 02:02:28.549
it had in fact come back

02:02:28.549 --> 02:02:31.010
and that it wasn't only
just that one spot,

02:02:31.010 --> 02:02:33.763
it was all throughout
both of my lungs too.

02:02:33.763 --> 02:02:36.766
- By the way, your lab just
could not be more perfect.

02:02:36.766 --> 02:02:38.100
- Okay. Whoa.
- I know.

02:02:38.100 --> 02:02:39.477
Just weep in front of me.

02:02:39.477 --> 02:02:41.270
- I know, now, out of joy, yes.

02:02:41.270 --> 02:02:42.730
- Yeah.

02:02:42.730 --> 02:02:44.523
And your blood counts
are totally normal.

02:02:44.523 --> 02:02:47.109
I think we were all
three, the three of us,

02:02:47.109 --> 02:02:52.114
spooked by what transpired
after you were treated at first

02:02:52.114 --> 02:02:54.450
when I didn't expect
to see you so soon

02:02:54.450 --> 02:02:57.119
and then suddenly you're
at our doorstep again.

02:02:57.119 --> 02:02:59.121
- Therefore my
episode last month

02:02:59.121 --> 02:03:01.791
when I had to deal with
my but I'm worried.

02:03:01.791 --> 02:03:04.543
- We're longer after
transplant than the interval

02:03:04.543 --> 02:03:07.463
between completion of
chemo and the recurrence.

02:03:07.463 --> 02:03:09.215
And then we continue from there.

02:03:09.215 --> 02:03:11.133
- Yeah.

02:03:11.133 --> 02:03:13.135
And Saturday morning, then
I get an email from him

02:03:13.135 --> 02:03:15.262
and I was like, ooh, I could
see in the message line

02:03:15.262 --> 02:03:17.681
it already said in
capital letters "NORMAL"

02:03:17.681 --> 02:03:20.184
with about 10
exclamation points.

02:03:20.184 --> 02:03:21.394
And I was like ah!

02:03:21.394 --> 02:03:22.561
If I'm happy, I cry.

02:03:22.561 --> 02:03:24.438
If I'm sad, I cry.

02:03:24.438 --> 02:03:27.608
And so I grabbed Matt
right away and just said,

02:03:27.608 --> 02:03:29.527
"Oh my goodness."

02:03:29.527 --> 02:03:32.780
I'm just so grateful that
he said that it's normal.

02:03:34.365 --> 02:03:36.117
There was one time

02:03:37.410 --> 02:03:40.162
I was tucking my daughter in

02:03:40.162 --> 02:03:43.332
and I had just finished
reading with her,

02:03:43.332 --> 02:03:45.292
just finished praying with her.

02:03:45.292 --> 02:03:48.337
We were chit chatting about
things for a little bit.

02:03:48.337 --> 02:03:51.841
And I just started
crying because I thought,

02:03:51.841 --> 02:03:54.677
oh, I don't want this
to be the last time.

02:03:54.677 --> 02:03:57.346
Oh, I don't want
to give this up.

02:03:57.346 --> 02:03:59.723
I don't wanna, I don't
want to lose them.

02:03:59.723 --> 02:04:02.476
I don't want them to lose me.

02:04:02.476 --> 02:04:05.521
But, oh God's timing
is amazing, you know?

02:04:05.521 --> 02:04:08.190
I don't know why I
happened to be the one

02:04:08.190 --> 02:04:10.234
that got to be used.

02:04:10.234 --> 02:04:12.653
I mean, from Dr.
Forman just happened

02:04:12.653 --> 02:04:15.865
to be doing these clinical
trials at that time.

02:04:15.865 --> 02:04:19.243
I just happened to
recur at the time

02:04:19.243 --> 02:04:22.288
that they're doing
these clinical trials

02:04:22.288 --> 02:04:25.708
and the fact that it's
so far successful.

02:04:25.708 --> 02:04:29.170
I mean, it just leaves
you in awe really.

02:04:30.880 --> 02:04:32.631
- Dr. Jay, here's Andrew.
- Hello, hello.

02:04:32.631 --> 02:04:34.550
Hey Andrew, how are you?
- Good to see you.

02:04:34.550 --> 02:04:36.635
- Good to see you, my friend.

02:04:36.635 --> 02:04:39.180
I'm used to seeing
you without any hair.

02:04:39.180 --> 02:04:41.891
- Yeah. This is
all pretty recent.

02:04:41.891 --> 02:04:43.392
- You look great.

02:04:43.392 --> 02:04:44.852
And you're feeling well?

02:04:44.852 --> 02:04:47.730
- Yeah, I feel great.
- Now this is month?

02:04:47.730 --> 02:04:52.193
- This is, well, I have a month
six checkup for next week.

02:04:52.193 --> 02:04:54.528
- Got it.
- I think it's next week yeah.

02:04:54.528 --> 02:04:57.823
- 'Cause the good news
that we have to share

02:04:57.823 --> 02:05:00.493
is that checking
your T-cell count,

02:05:00.493 --> 02:05:02.453
it came back at 486.

02:05:02.453 --> 02:05:04.288
- Oh wow.
- Did you know that?

02:05:04.288 --> 02:05:05.664
- No.

02:05:05.664 --> 02:05:08.209
Yeah. And as you
know we have criteria

02:05:08.209 --> 02:05:10.753
and that criteria
are details of 450.

02:05:10.753 --> 02:05:13.255
You're gonna be the first
person in this study

02:05:13.255 --> 02:05:16.592
who actually qualifies
to stop his antivirals.

02:05:16.592 --> 02:05:19.762
No one has received
genetically modified stem cells

02:05:19.762 --> 02:05:21.680
at this dose of chemotherapy

02:05:21.680 --> 02:05:23.724
and then stopped
their antivirals.

02:05:23.724 --> 02:05:26.393
You're the first person
in the world to do that.

02:05:26.393 --> 02:05:28.229
- Huh.

02:05:28.229 --> 02:05:30.189
So there's a lot of
information to be gleaned.

02:05:30.189 --> 02:05:31.899
- Yeah.

02:05:31.899 --> 02:05:34.360
- So know that whatever we're
learning here is important.

02:05:34.360 --> 02:05:36.654
- Yeah. No pressure.
- No pressure.

02:05:36.654 --> 02:05:37.947
(Andrew laughing)

02:05:37.947 --> 02:05:39.782
It's almost
impossible to express

02:05:39.782 --> 02:05:42.576
how grateful we are to you.

02:05:42.576 --> 02:05:44.870
- I have an enormous
gratitude for you.

02:05:44.870 --> 02:05:47.289
You've been doing
this for 30 years.

02:05:47.289 --> 02:05:49.291
- I have the gray
hairs to show it.

02:05:49.291 --> 02:05:52.253
And I speak from the
perspective of someone

02:05:52.253 --> 02:05:54.713
who started this
program in June 1989.

02:05:54.713 --> 02:05:56.632
And back in those days,

02:05:56.632 --> 02:05:59.343
we had two to three people
dying a week in this office.

02:05:59.343 --> 02:06:00.803
It's different now.

02:06:00.803 --> 02:06:02.888
You can take your
one pill once a day

02:06:02.888 --> 02:06:05.683
and you don't have
to go anywhere near
a research program.

02:06:05.683 --> 02:06:07.643
You certainly don't
have to get involved

02:06:07.643 --> 02:06:09.853
in a gene therapy
study with chemotherapy

02:06:09.853 --> 02:06:11.730
where we house you for a month

02:06:11.730 --> 02:06:14.233
because we wiped out
your bone marrow.

02:06:14.233 --> 02:06:15.943
I mean those are real risks.

02:06:15.943 --> 02:06:19.613
On behalf of all the people
who've been here at Quest

02:06:19.613 --> 02:06:23.492
over the decades, most of
whom are not here anymore.

02:06:23.492 --> 02:06:26.996
They're all I think
with us in this moment

02:06:26.996 --> 02:06:30.666
in awe that you were
willing to take on

02:06:30.666 --> 02:06:34.003
this amount of
risk to cure AIDS.

02:06:34.003 --> 02:06:36.839
And whatever we learn here,

02:06:36.839 --> 02:06:41.844
it'll be because of the way
you stepped into service

02:06:41.844 --> 02:06:44.888
and volunteering for this.

02:06:46.515 --> 02:06:48.601
And that is the truth of it.

02:06:48.601 --> 02:06:50.728
- Meh, meh. (laughing)

02:06:50.728 --> 02:06:52.688
- Just don't date
your antivirals.

02:06:52.688 --> 02:06:55.649
See us every week and call
us if anything goes wrong.

02:06:55.649 --> 02:06:57.693
- Yeah. I can't
wait to call my mom.

02:06:57.693 --> 02:07:00.362
(phone ringing)

02:07:00.362 --> 02:07:01.822
Hello?
- Hi.

02:07:01.822 --> 02:07:04.408
- Hi. How are you?
- Fine, fine.

02:07:04.408 --> 02:07:06.619
How are you?
- I'm good.

02:07:06.619 --> 02:07:10.539
I'm the first person to
get above the threshold

02:07:10.539 --> 02:07:13.876
for the CD4 cells.
- Oh my God.

02:07:13.876 --> 02:07:15.377
- Yeah.
- You win.

02:07:15.377 --> 02:07:17.504
- I win. (laughing)

02:07:18.380 --> 02:07:20.049
- You win.

02:07:20.049 --> 02:07:22.051
- It'll probably
be within the month

02:07:22.051 --> 02:07:24.720
that I'll go into the
treatment interruption

02:07:24.720 --> 02:07:26.513
and stop taking my meds.

02:07:26.513 --> 02:07:28.682
The amount of chemo
that I received

02:07:28.682 --> 02:07:31.852
and the type of stem cell
transplant I received,

02:07:31.852 --> 02:07:34.480
I'm the first person
in the world to

02:07:36.315 --> 02:07:39.610
be able to get to this point
where I can go off my meds

02:07:39.610 --> 02:07:42.571
and see how well it all worked.

02:07:42.571 --> 02:07:44.823
- Wow. That's exciting.

02:07:44.823 --> 02:07:46.075
- Yeah. It's exciting.

02:07:46.075 --> 02:07:47.576
It's nerve wracking.

02:07:47.576 --> 02:07:48.911
It's humbling.

02:07:48.911 --> 02:07:51.789
It's scary.

02:07:51.789 --> 02:07:53.791
- Good gravy.

02:07:53.791 --> 02:07:55.918
I can't wait to
see what happens.

02:07:55.918 --> 02:07:59.088
- Yeah, yeah, yeah.
- This is a big deal.

02:07:59.088 --> 02:08:02.049
- This is a very
big deal. (laughing)

02:08:05.969 --> 02:08:09.098
- I really just don't want
to go through this anymore.

02:08:09.098 --> 02:08:10.891
You know?

02:08:12.434 --> 02:08:15.104
I wish there was some
way that it could stop.

02:08:34.998 --> 02:08:36.667
- Hey, how's it going?

02:08:36.667 --> 02:08:38.085
- Hey.
- Hey.

02:08:38.085 --> 02:08:39.420
- You doing okay?
- Yeah, yeah.

02:08:39.420 --> 02:08:41.964
- Feeling a little better or?

02:08:41.964 --> 02:08:44.550
- So you said,

02:08:44.550 --> 02:08:47.636
so things got worse on,

02:08:47.636 --> 02:08:49.638
I spoke to you on Friday, right?

02:08:49.638 --> 02:08:51.390
- Yeah, it was Friday.

02:08:51.390 --> 02:08:54.017
So the question is, let
me look at your scans.

02:08:57.146 --> 02:08:59.481
So the tumors,

02:08:59.481 --> 02:09:01.650
the different
areas of the tumor,

02:09:01.650 --> 02:09:05.571
the bulk of it, one part
looks a little bit more dead.

02:09:05.571 --> 02:09:08.073
One part, it looks progression.

02:09:08.073 --> 02:09:11.785
So there's one part
that's definitely bigger.

02:09:11.785 --> 02:09:14.621
So this is before we
gave you the injection.

02:09:14.621 --> 02:09:17.458
So this is from last month.
- That's October, yeah.

02:09:17.458 --> 02:09:20.002
- And this is a more
recent one. So...

02:09:21.086 --> 02:09:22.963
there's a deep portion here

02:09:22.963 --> 02:09:26.592
and I think that's
looking bigger. Okay.

02:09:26.592 --> 02:09:28.927
Some of this is dead tissue.

02:09:28.927 --> 02:09:30.012
Some is active.

02:09:30.012 --> 02:09:32.681
So the white is active.

02:09:38.020 --> 02:09:41.106
This back part, also
some of it is active,

02:09:41.106 --> 02:09:44.193
but so this is
obviously much bigger.

02:09:44.193 --> 02:09:46.820
The center's dead
but this is the more,

02:09:46.820 --> 02:09:49.198
the front part is
definitely bigger, yeah.

02:09:49.198 --> 02:09:51.200
- Yeah, geeze.

02:09:53.035 --> 02:09:56.705
- We can go remove this
and take most of this off.

02:09:56.705 --> 02:09:58.624
Okay?

02:09:58.624 --> 02:10:00.626
The question is whether
the T-cells can come back

02:10:00.626 --> 02:10:02.044
and penetrate all this.

02:10:02.044 --> 02:10:04.213
So that bulkier the tumor,

02:10:04.213 --> 02:10:06.465
it's harder for
them to penetrate

02:10:06.465 --> 02:10:09.510
unless they come from your
own blood or something.

02:10:09.510 --> 02:10:12.137
So, we should call
this progression.

02:10:12.137 --> 02:10:14.765
There is some swelling
around the brain.

02:10:14.765 --> 02:10:16.767
- But there's-
- But it is progression.

02:10:16.767 --> 02:10:17.893
- Yeah.
- Yeah.

02:10:17.893 --> 02:10:19.228
It's definitely progression.

02:10:19.228 --> 02:10:21.063
- So, okay.

02:10:21.063 --> 02:10:23.065
So basically...

02:10:23.065 --> 02:10:25.067
- So the question is options,

02:10:25.067 --> 02:10:28.237
we can say, okay,
well let's move on.

02:10:28.237 --> 02:10:30.781
I mean, the question
if you're willing

02:10:30.781 --> 02:10:34.117
to have another surgery
or the other option is to,

02:10:34.117 --> 02:10:36.203
you know, we tried the pembro,

02:10:36.203 --> 02:10:39.248
we can give you another
injection of CAR T cells

02:10:39.248 --> 02:10:42.751
if you want, but then
that's going back to...

02:10:42.751 --> 02:10:45.254
- That puts us
weeks, like, yeah.

02:10:47.005 --> 02:10:48.674
Okay.

02:10:48.674 --> 02:10:52.010
Do you feel as though
you have your answers

02:10:52.010 --> 02:10:54.012
that you were looking for?

02:10:54.012 --> 02:10:55.097
- Yeah.

02:10:55.097 --> 02:10:56.974
- And based on that...

02:10:58.809 --> 02:10:59.852
- Yeah.

02:11:00.894 --> 02:11:02.521
- Time to go?

02:11:02.521 --> 02:11:05.232
- Yeah.
- Yeah, okay.

02:11:05.232 --> 02:11:07.693
If you want, I can
do the surgery here

02:11:07.693 --> 02:11:10.070
and then give you
the extra T-cells

02:11:10.070 --> 02:11:12.865
or I'm sure you want
to get back home too.

02:11:12.865 --> 02:11:15.158
So it's up to you,
whatever you like to do.

02:11:17.035 --> 02:11:19.872
- I think that we need to
go and be with our family.

02:11:19.872 --> 02:11:22.958
- Yeah, I know, I know.

02:11:22.958 --> 02:11:27.629
- And let our kids have a
good Christmas, you know?

02:11:27.629 --> 02:11:30.632
- You know, I want to
make sure that you know,

02:11:30.632 --> 02:11:33.093
there's so many other
options that you have

02:11:33.093 --> 02:11:35.888
but I really understand
you want to go home too.

02:11:35.888 --> 02:11:37.764
And that's a hard decision.

02:11:37.764 --> 02:11:41.101
So, I wished it worked
out better for you, but...

02:11:41.101 --> 02:11:44.021
- Are you giving him
a hug? (laughing)

02:11:51.653 --> 02:11:52.863
- All right, honey.

02:11:52.863 --> 02:11:54.698
- I have to say I am scared.

02:11:54.698 --> 02:11:56.158
- Are you ready?
- No, I'm scared.

02:11:56.158 --> 02:11:57.826
I'm scared, I'm
scared. (laughing)

02:11:57.826 --> 02:11:59.661
Okay, can I back out now?

02:11:59.661 --> 02:12:00.829
Hi.

02:12:00.829 --> 02:12:02.331
- Are you ready?
Are you excited?

02:12:02.331 --> 02:12:03.707
- Yeah. I'm scared.

02:12:03.707 --> 02:12:05.167
- Oh, don't be.
- I'm excited.

02:12:05.167 --> 02:12:06.293
- You're gonna be so fine.
- Okay.

02:12:06.293 --> 02:12:08.170
- You're gonna really like it.

02:12:08.170 --> 02:12:11.757
- It's amazing to know that
in as little as five years

02:12:11.757 --> 02:12:15.052
someone with my eye
disease would be able to go

02:12:15.052 --> 02:12:18.096
to a clinic and just get
their stem cell injections

02:12:18.096 --> 02:12:20.057
and then improve their sight.

02:12:20.057 --> 02:12:22.935
I mean, it's surreal.

02:12:23.852 --> 02:12:25.938
It is surreal.

02:12:25.938 --> 02:12:28.857
- Can you reach up?

02:12:28.857 --> 02:12:30.692
So there's this one.

02:12:30.692 --> 02:12:32.694
Yeah, if you reach up
again a little bit further

02:12:32.694 --> 02:12:34.154
with your left hand too

02:12:34.154 --> 02:12:36.323
and then bring your left
foot up a little bit.

02:12:36.323 --> 02:12:37.908
Perfect.

02:12:37.908 --> 02:12:39.868
Now if you want to stand
up on your two feet.

02:12:39.868 --> 02:12:40.744
- Yeah.
- Okay.

02:12:40.744 --> 02:12:42.037
- Ooh.

02:12:42.037 --> 02:12:43.622
This one?
- Yes.

02:12:43.622 --> 02:12:45.207
- Holy cow.

02:12:45.207 --> 02:12:46.792
It's starting to get scary.

02:12:46.792 --> 02:12:49.044
- You're doing great.
- Good job, honey.

02:12:49.044 --> 02:12:50.963
- Okay.
- Honey, you're doing it.

02:12:50.963 --> 02:12:53.382
- So bring, it's a
little bit further.

02:12:53.382 --> 02:12:55.050
Instead of your left foot,

02:12:55.050 --> 02:12:57.094
put your right foot
up a little higher.

02:12:57.094 --> 02:12:59.054
- Okay.
- And there's a green one

02:12:59.054 --> 02:13:01.223
right to, yeah, perfect.

02:13:03.225 --> 02:13:05.978
- Right there?
- Yes, perfect.

02:13:05.978 --> 02:13:07.771
- All right, honey.

02:13:07.771 --> 02:13:10.232
- I'm totally scared.

02:13:10.232 --> 02:13:11.817
I got you, don't worry.
- Okay.

02:13:11.817 --> 02:13:13.151
(bell rings)

02:13:13.151 --> 02:13:14.403
- Awesome.
(crowd cheering)

02:13:14.403 --> 02:13:16.279
- Shut up, I did it, oh my god.

02:13:16.279 --> 02:13:17.823
Woo!

02:13:20.951 --> 02:13:22.869
- How've you been?

02:13:22.869 --> 02:13:24.329
- Good, how about you?

02:13:27.082 --> 02:13:29.126
- All right, good luck buddy.

02:13:29.126 --> 02:13:30.419
Don't wreck it.

02:13:30.419 --> 02:13:32.087
- See ya. I'll try not to.

02:13:32.087 --> 02:13:33.755
(engine starts)

02:13:39.928 --> 02:13:41.722
I'll drive like
a regular driver.

02:13:41.722 --> 02:13:43.849
- Drive like a regular driver.

02:13:43.849 --> 02:13:45.726
That's what you are now.

02:13:45.726 --> 02:13:47.978
- I want to be able to
drive so my parents,

02:13:47.978 --> 02:13:50.188
friends and family don't have
to worry about everything.

02:13:50.188 --> 02:13:52.399
- Sure, sure.

02:13:52.399 --> 02:13:54.026
You'll get there.

02:13:54.026 --> 02:13:55.902
- I just have no
idea where we are.

02:13:55.902 --> 02:13:58.071
(instructor laughing)

02:13:58.071 --> 02:14:01.158
- Get into the turn lane
forward, there you go.

02:14:02.784 --> 02:14:04.870
And then the light
we'll make a left.

02:14:04.870 --> 02:14:06.830
- Oh, I think I
remember this now.

02:14:06.830 --> 02:14:08.290
- Yeah.

02:14:08.290 --> 02:14:09.791
- It's almost like
my moods change.

02:14:09.791 --> 02:14:11.752
Like, okay, I'm just driving.

02:14:11.752 --> 02:14:13.211
I don't know if-
- Yeah.

02:14:13.211 --> 02:14:15.714
Once the equipment is
working appropriately

02:14:15.714 --> 02:14:18.967
and you learn how to use
it, you're just driving

02:14:18.967 --> 02:14:20.469
and how freeing is that?

02:14:20.469 --> 02:14:22.429
- That's kind of
how I felt today.

02:14:22.429 --> 02:14:24.431
After like a month
of just driving,

02:14:24.431 --> 02:14:25.932
I think it will just be-

02:14:25.932 --> 02:14:27.809
- It will just be normal.

02:14:27.809 --> 02:14:29.895
Just be like, hey, pick me
up or let's go wherever.

02:14:29.895 --> 02:14:31.396
So it'll just be, yeah.

02:14:33.273 --> 02:14:35.192
- How'd you do buddy?
- Passed.

02:14:35.192 --> 02:14:36.818
- Did you really?
- Yep.

02:14:36.818 --> 02:14:38.487
- That's awesome.
That is awesome.

02:14:38.487 --> 02:14:40.072
- Thank you.
- Yeah.

02:14:40.072 --> 02:14:42.240
- The fact that you can
do is amazing, Ryan.

02:14:42.240 --> 02:14:45.494
Just watching you drive
away, it blows me away.

02:14:45.494 --> 02:14:47.370
- It's crazy.

02:14:47.370 --> 02:14:49.456
- Caitlyn, thanks a lot
for everything you've done.

02:14:49.456 --> 02:14:51.458
- You're welcome. He was great.

02:14:55.462 --> 02:14:57.255
- You ready, babe?
- Yes.

02:14:57.255 --> 02:14:59.424
- Ready to go home.

02:14:59.424 --> 02:15:02.219
- I think our family
is a lot stronger

02:15:03.845 --> 02:15:05.514
now more than ever.

02:15:05.514 --> 02:15:08.850
Just going through this we
appreciate everything in life.

02:15:08.850 --> 02:15:11.311
We're so grateful for Ava.

02:15:11.311 --> 02:15:13.313
(group cheering)

02:15:13.313 --> 02:15:16.191
And it's just a miracle
how this all happened.

02:15:16.191 --> 02:15:20.821
How the right doctors,
the right specialists

02:15:20.821 --> 02:15:24.032
just came at the right
time to save her life.

02:15:24.032 --> 02:15:25.408
Where are we going?

02:15:25.408 --> 02:15:28.036
- To see Mickey Mouse.
- Mickey Mouse?

02:15:28.036 --> 02:15:29.037
- Yeah.

02:15:29.037 --> 02:15:32.457
(uplifting music)

02:15:32.457 --> 02:15:34.251
- When she was a newborn

02:15:34.251 --> 02:15:36.419
and when she was
sick in the hospital,

02:15:36.419 --> 02:15:39.214
all I ever prayed for was
for her to run around,

02:15:39.214 --> 02:15:42.884
make friends and
just be the normal

02:15:42.884 --> 02:15:46.388
two, three, four year
old that she could be.

02:15:48.056 --> 02:15:49.224
- Yeah!

02:15:49.224 --> 02:15:51.977
Oh yeah!
- Oh yeah.

02:15:51.977 --> 02:15:53.895
- My turn.

02:15:57.107 --> 02:15:58.400
- She has it.

02:16:00.152 --> 02:16:02.487
Creating new childhood memories,

02:16:02.487 --> 02:16:04.156
that's all I ever wanted

02:16:04.156 --> 02:16:07.409
and experience just
a normal childhood

02:16:07.409 --> 02:16:10.829
and play in the
sand, play outside,

02:16:10.829 --> 02:16:13.206
even just being
naughty (laughing)

02:16:13.206 --> 02:16:15.917
and just running around,
getting into things.

02:16:15.917 --> 02:16:19.129
It was all I ever looked
forward to as well.

02:16:19.129 --> 02:16:22.257
It's really exciting
to see her grow up now

02:16:22.257 --> 02:16:24.176
outside of the hospital.

02:16:29.472 --> 02:16:32.058
- There are a number of diseases

02:16:32.058 --> 02:16:34.269
that eventually could be treated

02:16:34.269 --> 02:16:37.606
by the fruits of
stem cell biology

02:16:37.606 --> 02:16:40.025
and stem cell medicine.

02:16:40.025 --> 02:16:41.526
Sickle cell anemia,

02:16:41.526 --> 02:16:45.530
juvenile diabetes, lupus,

02:16:45.530 --> 02:16:49.618
multiple sclerosis, strokes,

02:16:49.618 --> 02:16:53.955
heart attacks, Lou
Gehrig's disease,

02:16:53.955 --> 02:16:58.960
Huntington's disease,
Parkinson's disease,
AIDS, hepatitis.

02:17:00.295 --> 02:17:02.964
So in the next five to 10 years

02:17:02.964 --> 02:17:06.301
we will have an era of
regenerative medicine.

02:17:06.301 --> 02:17:08.929
And I think years from now,

02:17:08.929 --> 02:17:12.182
you'll look back and we'll
wonder how we ever did it

02:17:12.182 --> 02:17:15.435
and why we didn't see
how clearly it was

02:17:15.435 --> 02:17:17.646
that we have in our own bodies

02:17:17.646 --> 02:17:20.523
the cells that know how
to regenerate our body.

02:17:20.523 --> 02:17:24.069
We just didn't know how to
deliver it or improve it.

02:17:26.655 --> 02:17:29.032
- It's perfect.

02:17:29.032 --> 02:17:30.992
Girls, girls look.

02:17:30.992 --> 02:17:32.535
Look, girls.

02:17:32.535 --> 02:17:36.289
- Whoa, it's perfect.
- It's perfect.

02:17:36.289 --> 02:17:38.291
- It's snowing.

02:17:40.001 --> 02:17:41.419
- It's perfect.

02:17:43.505 --> 02:17:44.673
Hey, Steve.

02:17:45.966 --> 02:17:48.677
- No, Summer, it's too heavy.

02:17:48.677 --> 02:17:51.179
- Love you.

02:17:51.179 --> 02:17:53.640
(somber music)

02:18:33.054 --> 02:18:34.639
- Hi, everybody.

02:18:34.639 --> 02:18:39.644
This is me and my family
and I am about 20 months

02:18:41.229 --> 02:18:43.315
out from the time that
I had my transplant

02:18:43.315 --> 02:18:45.317
and feeling really good.

02:18:45.317 --> 02:18:47.235
I've been back to work.

02:18:47.235 --> 02:18:50.405
Enjoying the kids soccer games

02:18:50.405 --> 02:18:52.699
and cross country
and school events.

02:18:52.699 --> 02:18:56.202
And yeah, life feels like
it's almost completely

02:18:56.202 --> 02:18:58.079
back to normal.

02:18:58.079 --> 02:18:59.414
- What's a transplant?

02:18:59.414 --> 02:19:00.665
- A transplant?

02:19:00.665 --> 02:19:02.208
- Yeah, you're a plant.

02:19:02.208 --> 02:19:03.543
- No, I'm not a plant.

02:19:03.543 --> 02:19:04.753
- Yes, you are.

02:19:06.338 --> 02:19:08.673
- When something new
was put into my body

02:19:08.673 --> 02:19:11.134
to help the the cancer--

02:19:11.134 --> 02:19:12.260
- Your body.

02:19:12.260 --> 02:19:14.012
- The cancer go away.

02:19:14.012 --> 02:19:16.222
- All right, I guess that's all.

02:19:16.222 --> 02:19:17.557
- Can I do it?
- What?

02:19:17.557 --> 02:19:19.059
- Undo it?
- Yes.

02:19:19.059 --> 02:19:19.726
- Yes.

02:19:21.019 --> 02:19:22.437
Hello, people.

02:19:22.437 --> 02:19:24.147
(Cheryl laughing)